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Inner City Asthma consortium 3 (ICAC3)

Inner City Asthma consortium 3 (ICAC3)
内城哮喘协会 3 (ICAC3)
批准号：
9755346
负责人：
James E. Gern
金额：
$1120.62万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
项目状态：
已结题
起止时间：
2014-08-05 至 2021-07-31
来源：
https://reporter.nih.gov/project-details/9755346
关键词：
16 year oldAddressAdolescenceAdolescentAllergen ImmunotherapyAllergensAllergicAnti-CholinergicsAsthmaBacteriaBiologicalBirthCaringCellsCharacteristicsChildChildhoodChildhood AsthmaClinicalCohort StudiesCollaborationsComplexDevelopmentDictyopteraDiseaseDisease ProgressionDisease remissionEnvironmentEnvironmental ExposureEnvironmental Risk FactorEpidemicEpigenetic ProcessEpitopesExposure toGoalsGrantGuidelinesHouse DustHouseholdIgEImmuneImmune responseImmunobiologyImmunologicsImmunotherapyIncidenceInterleukin-5InterventionLeadLeptinLifeLinkMediatingMetabolicMicrobeNursery SchoolsObesityOutcomeParticipantPeripheral Blood EosinophiliaPhenotypePlasmaPopulationPrevalencePreventionProcessProtocols documentationRecurrenceResearch DesignRespiratory Tract InfectionsRiskRisk FactorsRoleSeveritiesShapesSourceStimulusSystems BiologyT cell responseT-LymphocyteTestingWheezingWorkagedairborne allergenallergic airway diseaseasthmaticasthmatic patientbasecockroach allergencohortdesigndisorder controlearly childhoodgenetic risk factorgut microbiomehigh riskimmunoregulationimprovedin uteroinfancyinner citymepolizumabmicrobialmicrobiomemicrobiome compositionmouse allergenomalizumabpreventrespiratory microbiomeresponsesubcutaneoustherapy design

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DESCRIPTION (provided by applicant): ICAC's goal is to include further development of cockroach allergen immunotherapy and consideration of new allergen immunotherapies; for example to mouse allergens; the development and execution of clinical and mechanistic studies targeted to inner-city asthma phenotypes, and interventions designed to prevent the incidence of asthma or its progression. In addition, the URECA birth cohort study will be continued to the end of the grant, when the participants will range from 14 to 16 years of age, with the goal to provide information on the immunologic basis of late childhood and adolescence-onset asthma, as well as the remission of asthma during the same years.
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