Connecting Sex to Platelet Function after Mechanical Activation
机械激活后将性别与血小板功能联系起来
基本信息
- 批准号:9758832
- 负责人:
- 金额:$ 3.99万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-06-16 至 2022-06-15
- 项目状态:已结题
- 来源:
- 关键词:AddressAdhesionsAffectAgonistBindingBiochemicalBiologyBiophysicsBlood PlateletsBlood coagulationCardiovascular DiseasesCause of DeathCellsClinicalCoagulation ProcessDNADevelopmentDiseaseEffectivenessEnvironmentExhibitsFemaleFutureGeneticGlycoproteinsGoalsGrantHemorrhageHemostatic functionHormonalIncidenceIntegrinsInvestigationIschemic StrokeLeadLigandsMeasuresMechanicsMechanoreceptorsMicrofluidicsMolecularMyocardial InfarctionMyocardial IschemiaOutcomePlatelet ActivationPlatelet Count measurementPlatelet GlycoproteinsPlayProcessReceptor ActivationResearch PersonnelRiskRoleSex DifferencesStrokeSubjects SelectionsSurfaceTestingThromboembolismThrombosisTractionTraumaVenousWorkbasecurative treatmentsdesignflexibilitymalemechanotransductionmortalityplatelet functionpolydimethylsiloxanepreventreceptorresearch studyresponsesensorsexshear stress
项目摘要
Cardiovascular disease is the most common cause of death worldwide. Differences in
cardiovascular disease in males and females have been well established, but despite the
importance of thrombosis in ischemic stroke, ischemic heart disease, and venous
thromboembolism, sex differences in platelet function are often absent from the conversation.
None the less, males and females have differences in bleeding risk, response to anti-platelet
therapy, thrombosis-related disease incidence and outcomes, and mortality post-trauma. In
combination with hormonal and genetic factors, differences may be due to variability in platelet
biology such as well-established differences in platelet count, alleged differences in expression of
key surface receptors, and variability of surface receptor activation. While previous work has
used clinical tests to examine differences in thrombotic function between males and females and
found modest significant differences or no significant differences, these tests use classic
biochemical agonists to activate platelets, rather than biophysical activation of the
mechanoreceptors platelet glycoprotein Ibα (GPIbα) and integrin αIIbβ3. In this work, I seek to
investigate how sex affects mechanically-activated platelet function, which is critical in arterial
thrombosis. The goal of this grant is to determine whether hemostatic function varies by sex
under arterial, high-shear activated environments without exogenous biochemical agonists. I will
also address whether sex differences exist in aspects of platelet biology related to arterial
thrombosis, including mechanical activatability of platelet mechanoreceptors GPIbα and integrin
αIIbβ3, platelet adhesion in flow, and platelet contractile forces. This investigation is important
because understanding variability in thrombosis between males and females will affect
characterization of healthy platelet function, design of future research studies, application of anti-
platelet treatments, and development of future preventative and curative therapeutics.
心血管疾病是全世界最常见的死亡原因。的差异
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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MOLLY YEANDEL MOLLICA其他文献
MOLLY YEANDEL MOLLICA的其他文献
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{{ truncateString('MOLLY YEANDEL MOLLICA', 18)}}的其他基金
Connecting Sex to Platelet Function after Mechanical Activation
机械激活后将性别与血小板功能联系起来
- 批准号:
10165809 - 财政年份:2019
- 资助金额:
$ 3.99万 - 项目类别:
Connecting Sex to Platelet Function after Mechanical Activation
机械激活后将性别与血小板功能联系起来
- 批准号:
9976997 - 财政年份:2019
- 资助金额:
$ 3.99万 - 项目类别:
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