Connecting Sex to Platelet Function after Mechanical Activation
Connecting Sex to Platelet Function after Mechanical Activation
批准号:
10165809
负责人:
MOLLY YEANDEL MOLLICA
金额:
$3.79万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
已结题
起止时间:
2019-06-16 至 2022-05-02
关键词:
AddressAdhesionsAffectAgonistBindingBiochemicalBiologyBiophysicsBlood PlateletsBlood coagulationCardiovascular DiseasesCause of DeathCellsClinicalCoagulation ProcessDNADevelopmentDiseaseEffectivenessEnvironmentExhibitsFemaleFutureGeneticGlycoproteinsGoalsGrantHemorrhageHemostatic functionHormonalIncidenceIntegrinsInvestigationIschemic StrokeLeadLigandsMeasuresMechanicsMechanoreceptorsMicrofluidicsMolecularMyocardial InfarctionMyocardial IschemiaOutcomePlatelet ActivationPlatelet Count measurementPlatelet GlycoproteinsPlayProcessReceptor ActivationResearch PersonnelRiskRoleSex DifferencesStrokeSubjects SelectionsSurfaceTestingThrombosisTractionWorkbasecurative treatmentsdesignflexibilityforce sensormalemechanotransductionmortalityplatelet functionpolydimethylsiloxanepost-traumapreventreceptorresearch studyresponsesexshear stressthromboticvenous thromboembolism
中文摘要
心血管疾病是全世界最常见的死亡原因。的差异
英文摘要
Cardiovascular disease is the most common cause of death worldwide. Differences in
cardiovascular disease in males and females have been well established, but despite the
importance of thrombosis in ischemic stroke, ischemic heart disease, and venous
thromboembolism, sex differences in platelet function are often absent from the conversation.
None the less, males and females have differences in bleeding risk, response to anti-platelet
therapy, thrombosis-related disease incidence and outcomes, and mortality post-trauma. In
combination with hormonal and genetic factors, differences may be due to variability in platelet
biology such as well-established differences in platelet count, alleged differences in expression of
key surface receptors, and variability of surface receptor activation. While previous work has
used clinical tests to examine differences in thrombotic function between males and females and
found modest significant differences or no significant differences, these tests use classic
biochemical agonists to activate platelets, rather than biophysical activation of the
mechanoreceptors platelet glycoprotein Ibα (GPIbα) and integrin αIIbβ3. In this work, I seek to
investigate how sex affects mechanically-activated platelet function, which is critical in arterial
thrombosis. The goal of this grant is to determine whether hemostatic function varies by sex
under arterial, high-shear activated environments without exogenous biochemical agonists. I will
also address whether sex differences exist in aspects of platelet biology related to arterial
thrombosis, including mechanical activatability of platelet mechanoreceptors GPIbα and integrin
αIIbβ3, platelet adhesion in flow, and platelet contractile forces. This investigation is important
because understanding variability in thrombosis between males and females will affect
characterization of healthy platelet function, design of future research studies, application of anti-
platelet treatments, and development of future preventative and curative therapeutics.
期刊论文(2)
专著(0)
科研奖励(0)
会议论文
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DOI:
10.1115/1.4063819
发表时间:
2023
期刊:
Journal of Biomechanical Engineering
影响因子:
--
作者:
[Mollica, Molly Y., Olszewski, Emily, Kiyohara, Casey, Matusalem, Danafe, Ochs, Alexander, Imoukhuede, Princess, Regnier, Michael, Yasuhara, Ken, Thomas, Wendy, Taylor, Alyssa C.]
通讯作者:
Taylor, Alyssa C.
Connecting Sex to Platelet Function after Mechanical Activation
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批准号:9976997
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项目类别:
-
资助金额:$4.05万
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财政年份:2019
-
负责人:MOLLY YEANDEL MOLLICA
-
依托单位:
Connecting Sex to Platelet Function after Mechanical Activation
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批准号:9758832
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项目类别:
-
资助金额:$3.99万
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财政年份:2019
-
负责人:MOLLY YEANDEL MOLLICA
-
依托单位:
海外基金