Comparison of Hemorrhagic & Ischemic Stroke Among Blacks and Whites

出血性比较

基本信息

批准号：
9887666
负责人：
BRETT M KISSELA
金额：
$ 156.45万
依托单位：
UNIVERSITY OF CINCINNATI
依托单位国家：
美国
项目类别：
财政年份：
1992
资助国家：
美国
起止时间：
1992-09-22 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9887666
关键词：
Acute Address African American Age Age of Onset Anticoagulants Attenuated Benchmarking Black race Brain hemorrhage Case Fatality Rates Case Series Censuses Clinical Clinical Data Clinical Trials Cognitive Collaborations Communities Community Hospitals County Data Diagnostic radiologic examination Eligibility Determination Epidemiology Evaluation Event Exclusion Criteria Funding Future Health Services Accessibility Hospitals Incidence Intervention Studies Ischemic Stroke Kentucky Knowledge Methods Monitor Outcome Outpatients Participant Patients Physicians Population Population Study Prevalence Prevention Prevention trial Public Health Quality of life Recovery Recurrence Research Research Personnel Resources Risk Factors Science Secondary Prevention Sex Differences Site Source Stroke Stroke prevention Surveys Testing Time Time trend Transient Ischemic Attack Translating Treatment outcome United States United States National Institutes of Health Woman Work administrative database biracial clinical practice cohort disability functional outcomes health disparity high risk improved men metropolitan mortality novel population based population survey post stroke post stroke depression prospective racial difference racial disparity rate of change sex disparity stroke clinical trials stroke event stroke incidence stroke intervention stroke outcome stroke patient stroke recovery stroke risk stroke therapy trend

项目摘要

PROJECT SUMMARY: We seek to continue our population-based study of stroke incidence and case fatality, prevalence of risk factors, stroke treatment, and post-stroke outcomes within a biracial metropolitan population of 1,368,604 of whom 223,417 (16.3%) are of black race (US Census 2010). We expect to identify ~4500 physician confirmed and well characterized stroke events (projected 2900 ischemic strokes, 525 hemorrhagic strokes, and 1075 transient ischemic attack [TIA]) among residents of the five-county Greater Cincinnati/Northern Kentucky (GCNK) region at all 20 regional hospitals/EDs for the period 7/1/2019 to 12/31/2020, as well as 2,000 survey participants. For almost 25 years, we have studied trends in stroke incidence and case fatality and have demonstrated a racial disparity where stroke incidence in African-Americans is more than double that of whites. In each prior study period, we have also examined the prevalence of risk factors (and knowledge of stroke) via a population survey in order to put our temporal trend findings into context. In addition to continuing these important activities, we also examined stroke recurrence in a population- based fashion in our prior study period, finding that blacks were more likely to have recurrent events than whites. We now seek to evaluate temporal trends in recurrence rates, and specifically racial disparities in those temporal trends. Previously we had piloted methods of obtaining a population-based outcome among stroke patients, and we are now ready to obtain outcomes after ischemic stroke across our entire population, data that are desperately needed in the field. Finally, we have used our data to inform eligibility for stroke clinical trials via a close collaboration with NIH StrokeNet and have shared our data with the scientific community for this purpose. By obtaining more detailed outcomes data, we will now be able to better inform proposed recovery and prevention trials as well.

项目摘要：我们寻求继续基于人群的中风发生率和病例死亡的研究，风险患病率在混血儿大都市人口中，因素，中风治疗和中风后结果为1,368,604 223,417（16.3％）是黑人种族（美国人口普查2010）。我们希望确定约4500名医师确认和表征良好的中风事件（预计2900个缺血性中风，525次出血性中风和1075 五县大辛辛那提/北肯塔基州的居民中的短暂性缺血发作[TIA]）（GCNK）在2019年7月1日至12/31/2020的所有20家区域医院/ED的地区，以及2,000次调查参与者。在将近25年的时间里，我们研究了中风发生率和病例死亡的趋势，并证明了一个非裔美国人中风发生率的种族差异是白人的两倍以上。在每个先前研究期，我们还研究了通过人群的危险因素（和中风知识）的流行率调查是为了将我们的时间趋势发现置于环境中。除了继续这些重要活动外，我们还研究了人群中的中风复发 - 在我们以前的学习期间，基于时尚，发现黑人比相比更有可能发生复发事件白人。我们现在寻求评估复发率的时间趋势，特别是种族差异那些时间趋势。以前，我们采用了试点的方法来获得基于人群的结果中风患者，我们现在准备在整个人群中缺血性中风后获得结果，该领域迫切需要的数据。最后，我们使用数据来告知中风的资格通过与NIH Strokenet进行密切合作的临床试验，并与科学分享了我们的数据为此目的社区。通过获取更详细的结果数据，我们现在将能够更好地告知提议的恢复和预防试验。