APRISE Dementia (Assessing Population-based Radiological brain health in Stroke Epidemiology-Dementia)

APRISE 痴呆（中风流行病学-痴呆中基于人群的放射学脑健康评估）

• 批准号: 10029149
• 负责人: BRETT M KISSELA
• 金额: $ 196.34万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-15 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10029149
• 关键词: Address; African American; Alzheimer' s Disease; Alzheimer' s disease related dementia; Ancillary Study; Blood Vessels; Brain hemorrhage; Brain imaging; Cerebrum; Clinical; Cognitive; Complement; Data; Dementia; Deterioration; Diagnosis; Disease; Elderly; Epidemic; Epidemiology; Event; Funding; Future; Genetic; Goals; Grant; Health Planning; Heart Diseases; Image; Impaired cognition; Impairment; Incidence; Individual; Infrastructure; International Classification of Disease Codes; Intervention; Investigation; Investments; Ischemic Stroke; Kentucky; Knowledge; Lacunar Infarctions; Lead; Learning; Magnetic Resonance Imaging; Malignant Neoplasms; Measures; Medical Records; Methods; Microvascular Dysfunction; Modeling; Modernization; National Institute of Neurological Disorders and Stroke; Nerve Degeneration; Pathway interactions; Patients; Population; Population Heterogeneity; Population Study; Predisposition; Process; Public Health; Race; Radiology Specialty; Recording of previous events; Recovery; Research Design; Risk; Risk Factors; Sentinel; Severities; Stroke; Surveys; Time; Tissues; United States; United States National Institutes of Health; Validation; White Matter Hyperintensity; Work; base; biracial; black/white disparity; brain health; cerebral atrophy; cohort; cost; cost efficient; epidemiology study; high risk; improved; indexing; innovation; mixed dementia; novel; population based; post stroke; post stroke dementia; predictive modeling; programs; prospective; racial diversity; spectrograph; stroke event; stroke patient; stroke victims; tool; vascular contributions; vascular risk factor

DESCRIPTION/ABSTRACT: Dementia is a major burden, costing more than cancer and heart disease, and expected to double by 2060, and disproportionately in African-Americans. Among the parameters leading to post stroke dementia (PSD), vascular causes, including small vessel disease, represent a silent epidemic in need of further characterization epidemiologically. Further population-based studies of PSD, both in terms of incidence and characterization, are needed in the United States to allow for national projections and public health planning. Currently, we also lack an established prediction tool for PSD. A Framingham-like “Risk Function Tool for Post-Stroke Dementia,” especially one incorporating the full gamut of modern imaging parameters developed in a racially diverse population, would likely identify high-risk patients for targeted interventions. Moreover, it may reveal novel causal pathways and risk factors for future investigation. We propose an ancillary study to the NIH-funded Assessing Population-based Radiological brain health in Stroke Epidemiology (APRISE) study entitled, APRISE-Dementia. Our objective is to build on the GCNKSS and APRISE infrastructures which will have radiologically characterized the full stroke/TIA population of Greater Cincinnati/Northern Kentucky from 2015 and created the first modern, largely MRI-based characterization of brain health in a contemporary stroke/TIA population, and determine the population-based incidence, clinical and demographic features, and predictors of PSD up to five years after the incident stroke/TIA. Our specific aim is to create a prediction model of PSD incorporating imaging parameters in a biracial ischemic stroke/hemorrhagic stroke/TIA population using state-of-the-art modeling approaches. We hypothesize that diagnosis of PSD (within five years from index stroke event) will be better predicted by incorporating imaging parameters compared to traditional vascular risk factors alone. We will achieve these goals in a remarkably cost- and time-efficient manner by leveraging the extensive imaging, clinical and demographic data of stroke/TIA patients from 2015 already being collected in the currently funded APRISE and GCKNSS grants. Our project will not only provide the first population-level incidence of PSD projected nationally and innovatively utilize the entire imaging spectrum of brain health for prediction, but it will also generate novel hypotheses for prospective validation and refinement in the prospective NINDS/NIA- funded U19 DISCOVERY cohort. With the infrastructures already in place, we are uniquely ready to address these urgent questions.

描述/文摘:

项目成果

Outcome after acute ischemic stroke is linked to sex-specific lesion patterns.

急性缺血性中风后的结果与性别特异性病变模式有关。

• DOI: 10.1038/s41467-021-23492-3
• 发表时间: 2021-06-02
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Bonkhoff AK;Schirmer MD;Bretzner M;Hong S;Regenhardt RW;Brudfors M;Donahue KL;Nardin MJ;Dalca AV;Giese AK;Etherton MR;Hancock BL;Mocking SJT;McIntosh EC;Attia J;Benavente OR;Bevan S;Cole JW;Donatti A;Griessenauer CJ;Heitsch L;Holmegaard L;Jood K;Jimenez-Conde J;Kittner SJ;Lemmens R;Levi CR;McDonough CW;Meschia JF;Phuah CL;Rolfs A;Ropele S;Rosand J;Roquer J;Rundek T;Sacco RL;Schmidt R;Sharma P;Slowik A;Söderholm M;Sousa A;Stanne TM;Strbian D;Tatlisumak T;Thijs V;Vagal A;Wasselius J;Woo D;Zand R;McArdle PF;Worrall BB;Jern C;Lindgren AG;Maguire J;Bzdok D;Wu O;MRI-GENIE and GISCOME Investigators and the International Stroke Genetics Consortium;Rost NS
• 通讯作者: Rost NS

Acute Stroke Imaging Research Roadmap IV: Imaging Selection and Outcomes in Acute Stroke Clinical Trials and Practice.

• DOI: 10.1161/strokeaha.121.035132
• 发表时间: 2021-08
• 期刊: Stroke
• 影响因子: 8.3
• 作者: Campbell BCV;Lansberg MG;Broderick JP;Derdeyn CP;Khatri P;Sarraj A;Saver JL;Vagal A;Albers GW;STAIR XI Consortium
• 通讯作者: STAIR XI Consortium

The relevance of rich club regions for functional outcome post-stroke is enhanced in women.

• DOI: 10.1002/hbm.26159
• 发表时间: 2023-03
• 期刊: Human brain mapping
• 影响因子: 4.8