Brain and Adipose Contributors to Food Seeking in Youth with Adrenal Hyperplasia

大脑和脂肪对患有肾上腺增生的青少年寻求食物有贡献

• 批准号: 9475240
• 负责人: Mimi Susan Kim
• 金额: $ 17.09万
• 依托单位: CHILDREN'S HOSPITAL OF LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-18 至 2020-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9475240
• 关键词: Abdomen; Adipose tissue; Affect; Age; Amygdaloid structure; Animal Experimentation; Animal Model; Area; Attention; Award; Behavior; Behavioral; Biology; Body Composition; Body fat; Brain; Brain imaging; Brain region; California; Calories; Caring; Child; Childhood; Clinical Research; Congenital adrenal hyperplasia; Cues; Data; Decision Making; Desire for food; Discipline; Dual-Energy X-Ray Absorptiometry; Endocrine; Endocrine System Diseases; Endocrinology; Epidemic; Exhibits; Fasting; Fatty acid glycerol esters; Feedback; Food; Functional Magnetic Resonance Imaging; Funding; Genetic; Goals; Growth and Development function; Health; Health Care Costs; Health Food; Healthcare Systems; Hormones; Human; Hydrocortisone; Hyperphagia; Hypothalamic structure; Image; Imagery; Impairment; Institutes; Intervention; Investigation; Lead; Learning; Lesion; Los Angeles; Magnetic Resonance Imaging; Measures; Medical; Mentors; Mentorship; Metabolic; Metabolic hormone; Metabolism; Methodology; Motivation; Neonatal Screening; Neuroanatomy; Neurobiology; Neurosecretory Systems; Newborn Infant; Nucleus Accumbens; Obesity; Palate; Pathway interactions; Patient Self-Report; Pediatric Hospitals; Peripheral; Positioning Attribute; Prefrontal Cortex; Prevalence; Prevention; Process; Psychology; Research; Research Personnel; Rewards; Risk; Rodent; Satiation; Science; Scientist; Self-control as a personality trait; Statistical Methods; Structure; Study models; System; Taste Perception; Technical Expertise; Technology; Testing; Testosterone; Training; United States; United States National Institutes of Health; Weight Gain; Youth; abdominal fat; adipokines; adrenal hyperplasia; base; cohort; comparison group; craving; design; emotional stimulus; experience; feeding; human model; medical schools; metabolic abnormality assessment; motivated behavior; multidisciplinary; neurobehavior; neurobehavioral; neuroimaging; novel; obesity in children; pediatric department; prenatal; public health relevance; response; sex; therapy development

 DESCRIPTION (provided by applicant): The goal of the proposed mentored research is to investigate the neurobiology of food-seeking behaviors in children, and to provide Dr. Mimi Kim the in-depth training and mentorship to become an independent investigator in childhood obesity and metabolism. This proposal targets children with congenital adrenal hyperplasia (CAH) as a natural human model for the study of brain and adipose contributors to obesity. Her long-term goal is to become a clinical research leader in childhood obesity with an emphasis on prevention and treatment. Dr. Kim joined the Department of Pediatrics at the Keck School of Medicine of USC and the Division of Endocrinology at Children's Hospital Los Angeles in 2009 under the mentorship of Dr. Mitchell Geffner, an expert in childhood endocrine disorders, including CAH. Children with CAH have abnormalities in neuroendocrine function and brain structures related to self-control and reward, and are more likely to be obese than children without CAH. Specifically, Dr. Kim will measure food-seeking behavior, body fat, metabolic hormones, and brain activity in regions involved in reward (e.g., amygdala and nucleus accumbens) and inhibitory control (pre-frontal cortex) in children with CAH and in an unaffected comparison group (Non-CAH). Prior research has shown that children with CAH have abnormal amygdala volumes and function, and decreased inhibitory control during motivated behavior. Food-seeking behaviors have not been studied in children with CAH; however, there is a wealth of animal research on impaired amygdala function and food- seeking behavior. Dr. Kim hypothesizes that 1) a small amygdala, as observed in CAH, is associated with obesity, and that 2) children with CAH exhibit less inhibitory control and greater brain reward response to highly palatable food cues. The specific aims are to: 1) determine whether amygdala size is inversely associated with adiposity and body composition in CAH youth vs. Non-CAH youth; 2) determine whether activation of inhibitory control regions is decreased and activation of reward regions is increased in response to food cues in CAH youth; and 3) evaluate decision-making with regard to food choices in CAH and Non-CAH groups from Aim 1. Through mentored training and didactic learning, Dr. Kim will develop specific expertise in: 1) structural magnetic resonance imaging (MRI) of the brain and abdomen, 2) functional MRI of the brain and administering a food cues-based task in the scanner, 3) a neurobehavioral task involving food decision- making, and 4) statistical methods useful for conducting human research. Guided by highly expert and collaborative mentors from multiple disciplines, Dr. Kim will acquire technical skills and an understanding of how to effectively conduct and lead team science. Her project will establish a human model for the study of the amygdala, appetite, food-seeking behaviors, and obesity in children using sophisticated MRI measures. Understanding the neurobiology of food-seeking behaviors in children could inform much-needed development of interventions for obese children with and without CAH.



项目成果

Altered Emotion Perception Linked to Structural Brain Differences in Youth With Congenital Adrenal Hyperplasia.

先天性肾上腺增生症青少年的情绪感知改变与大脑结构差异有关。

• DOI: 10.1210/clinem/dgad158
• 发表时间: 2023
• 期刊: The Journal of clinical endocrinology and metabolism
• 作者: Omary,Adam;Khalifeh,Noor;Cotter,DevynL;Kim,MimiS;Choudhury,Farzana;Ahmadi,Hedyeh;Geffner,MitchellE;Herting,MeganM
• 通讯作者: Herting,MeganM

Assessment of Facial Morphologic Features in Patients With Congenital Adrenal Hyperplasia Using Deep Learning.

• DOI: 10.1001/jamanetworkopen.2020.22199
• 发表时间: 2020-11-02
• 期刊: JAMA network open
• 影响因子: 13.8
• 作者: AbdAlmageed W;Mirzaalian H;Guo X;Randolph LM;Tanawattanacharoen VK;Geffner ME;Ross HM;Kim MS
• 通讯作者: Kim MS

No evidence for a difference in 2D:4D ratio between youth with elevated prenatal androgen exposure due to congenital adrenal hyperplasia and controls.

• DOI: 10.1016/j.yhbeh.2020.104908
• 发表时间: 2021-03
• 期刊: Hormones and behavior
• 影响因子: 3.5
• 作者: Nave G;Koppin CM;Manfredi D;Richards G;Watson SJ;Geffner ME;Yong JE;Kim R;Ross HM;Serrano-Gonzalez M;Kim MS
• 通讯作者: Kim MS

Electrolyte abnormalities and stress dosing predict illness-related hospitalizations among infants and toddlers with congenital adrenal hyperplasia.

电解质异常和应激剂量可预测患有先天性肾上腺增生的婴儿和幼儿因疾病相关的住院治疗。

• DOI: 10.1111/cen.14876
• 发表时间: 2023
• 期刊: Clinical endocrinology
• 影响因子: 3.2
• 作者: Tseng,Teresa;Seagroves,Amy;Tanawattanacharoen,VeerayaK;Liang,MarkC;Koppin,ChristinaM;Keenan,Madison;Davidowitz,Elana;Nguyen,Eugene;Chand,Sanjay;Geffner,MitchellE;Chang,ToddP;Kim,MimiS
• 通讯作者: Kim,MimiS

Improved medical-alert ID ownership and utilization in youth with congenital adrenal hyperplasia following a parent educational intervention.

• DOI: 10.1515/jpem-2017-0435
• 发表时间: 2018-01-26
• 期刊: Journal of pediatric endocrinology & metabolism : JPEM
• 作者: Vidmar AP;Weber JF;Monzavi R;Koppin CM;Kim MS
• 通讯作者: Kim MS