No evidence for a difference in 2D:4D ratio between youth with elevated prenatal androgen exposure due to congenital adrenal hyperplasia and controls.
No evidence for a difference in 2D:4D ratio between youth with elevated prenatal androgen exposure due to congenital adrenal hyperplasia and controls.
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DOI：
10.1016/j.yhbeh.2020.104908
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发表时间：
2021-03
影响因子：
3.5
通讯作者：
Kim MS
中科院分区：
文献类型：
--
作者：
Nave G;Koppin CM;Manfredi D;Richards G;Watson SJ;Geffner ME;Yong JE;Kim R;Ross HM;Serrano-Gonzalez M;Kim MS
第二个和第四个手指的比例（2D:4D）与两性二态性有关，男性的2D:4D较低。大量的研究依赖于2D:4D作为产前雄激素暴露的代理，包括2D:4D与广泛的人类特征之间的关系的报告。在这里，我们通过研究2D:4D与典型先天性肾上腺增生（CAH）之间的关系来检验2D:4D代理的有效性，CAH是由21-羟化酶缺乏症引起的，CAH是一种以孕期大部分时间过量暴露于雄激素为特征的疾病。为此，我们回顾性分析了90例典型CAH青年（45例女性）和70例对照青年（31例女性）临床获得的513张左手系列x线片。重复先前的报道，我们观察到2D:4D与性别（男性2D:4D较低）和年龄（2D:4D随着发育而增加）有关。然而，我们没有发现CAH和对照组之间2D:4D差异的证据（全样本：β = - 0.001 (- 0.008, 0.006)）；女性：β =−0.004[−0.015,0.007]；男性：β = 0.001,[−0.008,0.011])。虽然我们的研究结果不排除2D:4D和CAH之间的小关联，但他们对2D:4D作为产前雄激素暴露在行为研究中的生物标志物的实用性提出了质疑。
The second-to-fourth digit ratio (2D:4D) has been associated with sexual dimorphism, with a lower 2D:4D in males. A large body of research has relied on the 2D:4D as a proxy for prenatal androgen exposure, and includes reports of relationships between 2D:4D and a wide range of human traits. Here, we examine the validity of the 2D:4D proxy by studying the association between 2D:4D and classical Congenital Adrenal Hyperplasia (CAH) due to 21-hydroxylase deficiency, a condition characterized by excessive prenatal exposure to androgens during most of the gestational period. To this end, we retrospectively examine 513 serial radiographs of the left hand obtained clinically in 90 youth with classical CAH (45 female) and 70 control youth (31 female). Replicating previous reports, we observe associations of the 2D:4D with sex (lower 2D:4D in males) and age (increase of 2D:4D through development). However, we find no evidence for differences in 2D:4D between CAH and controls (full sample: β = −0.001 (−0.008, 0.006)]; females: β = −0.004 [−0.015, 0.007]; males: β = 0.001, [−0.008, 0.011]). Although our findings do not rule out a small association between the 2D:4D and CAH, they cast doubt on the usefulness of the 2D:4D as a biomarker for prenatal androgen exposure in behavioral research.
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影响因子：
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作者：
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DOI：
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发表时间：
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影响因子：
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