FASEB SRC on Lysophospholipid and Related Mediators: From Bench to Clinic
关于溶血磷脂和相关介质的 FASEB SRC:从实验室到临床
基本信息
- 批准号:9761060
- 负责人:
- 金额:$ 0.59万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-07-01 至 2020-06-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAgonistAtmosphereAutoimmune DiseasesAutoimmune ProcessBindingBiochemical PathwayBiologicalBiologyBlood VesselsCancer BiologyCardiovascular DiseasesCareer ChoiceCatabolismCell SurvivalCellsCellular biologyCollaborationsCommunitiesComplexCountryCystic FibrosisDiagnosisDisciplineDiseaseDrug IndustryEducational workshopEmerging TechnologiesEmploymentEnzymesEuropeanEventFeesFunctional disorderFundingFutureG-Protein-Coupled ReceptorsGPR6 geneGenetic TranscriptionGoalsHealthHuman PathologyImmune System DiseasesImmunosuppressive AgentsInflammationInternationalKnowledgeLigandsLipidsLymphocyteLysophospholipidsMalignant NeoplasmsMediatingMediator of activation proteinMentorsMetabolismMinorityMissionMorphogenesisMultiple SclerosisNeoplasm MetastasisOccupationsOralOutcomeParticipantPathologicPhilosophyPhospholipidsPhysiologicalPlayPortugalProteinsPublic HealthRegenerative MedicineReproducibilityRequest for ApplicationsResearchResearch PersonnelRoleScienceScientistSignal TransductionSiteSphingolipidsSphingosine-1-Phosphate ReceptorStudentsTherapeutic EffectTrainingTranslational ResearchTranslationsTravelUnderrepresented MinorityUnited States National Institutes of HealthWomanWorkangiogenesisbench to bedsidebonecancer cellcancer therapycareercareer developmentclinical practicehuman diseaseimprovedinsightlysophosphatidic acidlysophosphatidylinositollysophosphatidylserinemeetingsmigrationmultidisciplinarynovelposterspreventprogramsreceptorresponsesphingosine 1-phosphatesphingosine kinasesummer researchsymposiumtherapeutic targettherapy developmenttraffickingtranslational scientist
项目摘要
Abstract
The FASEB Summer Research Conference on Lysophospholipid and Related Mediators-From Bench to Clinic
will be held July 28- August 2, 2019 at the Marriott Hotel in Lisbon, Portugal. This conference will address
current research and emerging concepts related mainly to the lysophospholipids sphingosine-1-phosphate
(S1P) and lysophosphatidic acid (LPA) and their roles in health and disease. S1P and LPA are lipid signaling
agonists that activate 5 and 6 G protein-coupled receptors, respectively and bind to intracellular target proteins
to regulate cell biology. These biological interactions control many functions related to regenerative medicine.
These lipids are important in cancer, cystic fibrosis, immunologic disorders and other physiopathological
disease states. Both receptors and intracellular enzymes regulating lysophospholipid metabolism have been
shown to function as potential therapeutic targets to diagnose, prevent or treat disease. The conference will
emphasize the translation of this work into clinical practice and highlight the research advances being made at a
rapid pace by many new investigators in this field. The meeting provides a unique forum for multidisciplinary
scientists within the field to meet and discuss their latest research findings in an informal and relaxed
atmosphere. Conference aims are to 1) provide intellectual exchange between scientists and trainees in
lysophospholipid research; 2) encourage and facilitate the active discussion between early career and new
investigators and established scientists via interactive career workshops; 3) provide opportunities for
networking/collaboration, career development/training, and job opportunities; and 4) provide a platform to
promote the participation of women and underrepresented minorities. The conference will allow diverse early
career and established investigators to communicate late breaking research results and promote future
interactions aligned with developing therapies for diseases where lysophospholipids play a predominant role.
The conference site in Portugal will facilitate maximum participation of European scientists with other countries
abroad and US counterparts to promote productive interactions focusing on the translational implications of
lysophospholipids.
摘要
FASEB溶血磷脂及相关介质夏季研究会议-从实验室到临床
将于2019年7月28日至8月2日在葡萄牙里斯本的万豪酒店举行。本次会议将讨论
目前的研究和新兴概念主要涉及溶血磷脂鞘氨醇-1-磷酸
(S1P)和溶血磷脂酸(LPA)及其在健康和疾病中的作用。S1 P和LPA是脂质信号传导
分别激活5和6 G蛋白偶联受体并结合细胞内靶蛋白的激动剂
来调节细胞生物学。这些生物相互作用控制着与再生医学相关的许多功能。
这些脂质在癌症、囊性纤维化、免疫疾病和其他生理病理学疾病中是重要的。
疾病状态。调节溶血磷脂代谢的受体和细胞内酶都已被发现。
显示作为潜在的治疗靶点来诊断、预防或治疗疾病。会议将
强调将这项工作转化为临床实践,并强调正在取得的研究进展,
许多新的研究人员在这个领域的快速步伐。会议提供了一个独特的论坛,
该领域的科学家们在一个非正式和轻松的会议上讨论他们的最新研究成果,
气氛会议的目的是1)提供科学家和学员之间的知识交流,
溶血磷脂研究; 2)鼓励和促进早期职业和新的职业之间的积极讨论
通过互动式职业讲习班,为研究人员和知名科学家提供机会; 3)
网络/协作,职业发展/培训和就业机会;以及4)提供平台,
促进妇女和代表性不足的少数群体的参与。会议将允许不同的早期
职业生涯和既定的研究人员交流最新的研究成果,并促进未来
这些相互作用与开发溶血磷脂发挥主要作用的疾病的疗法一致。
在葡萄牙的会议地点将促进欧洲科学家与其他国家的最大参与
国外和美国同行促进富有成效的互动,重点是翻译的影响,
溶血磷脂
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
The 2019 FASEB Science Research Conference on Lysophospholipid and Related Mediators: From Bench to Clinic, July 28 to August 2, 2019, Lisbon, Portugal.
2019年FASEB溶血磷脂及相关介质科学研究会议:从实验室到临床,2019年7月28日至8月2日,葡萄牙里斯本。
- DOI:10.1096/fj.201902224
- 发表时间:2019
- 期刊:
- 影响因子:0
- 作者:Smyth,SusanS;Natarajan,Viswanathan;McMullen,ColleenA
- 通讯作者:McMullen,ColleenA
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Susan S. Smyth其他文献
Passive antipyretic therapy is not as effective as invasive hypothermia for maintaining normothermia after cardiac arrest
- DOI:
10.1016/j.ajem.2021.06.069 - 发表时间:
2021-12-01 - 期刊:
- 影响因子:
- 作者:
Talal S. Alnabelsi;Sarah P. Faulkner;Matthew Cook;Kalen Freeman;Julie Shelton;Marc Paranzino;Sethabhisha Nerusu;Susan S. Smyth;Vedant A. Gupta - 通讯作者:
Vedant A. Gupta
When does the lung die? Kfc, cell viability, and adenine nucleotide changes in the circulation-arrested rat lung.
肺什么时候死亡?
- DOI:
10.1152/jappl.1997.83.1.247 - 发表时间:
1997 - 期刊:
- 影响因子:3.3
- 作者:
Thomas M. Egan;Randy M. Becker;J. Lemasters;Ya;Kuo Chu Hwang;Cheng;Yih;Susan S. Smyth;William K. Funkhouser;Keith Burridge;S. H. Randell;Monica Casiraghi;J. Abano;Jason R. Tatreau;M. Sevala - 通讯作者:
M. Sevala
Influences of Optimism, Sex, and Event-Related Medical Factors
乐观、性别和事件相关医疗因素的影响
- DOI:
- 发表时间:
2021 - 期刊:
- 影响因子:0
- 作者:
Amy L Ai;Susan S. Smyth - 通讯作者:
Susan S. Smyth
Susan S. Smyth的其他文献
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{{ truncateString('Susan S. Smyth', 18)}}的其他基金
Serum Amyloid as a Critical mediator between inflammation and thrombosis
血清淀粉样蛋白是炎症和血栓形成之间的关键介质
- 批准号:
9888883 - 财政年份:2020
- 资助金额:
$ 0.59万 - 项目类别:
Adipose autotaxin: a novel link between obesity and cardiovascular disease
脂肪自分泌运动因子:肥胖与心血管疾病之间的新联系
- 批准号:
9280845 - 财政年份:2015
- 资助金额:
$ 0.59万 - 项目类别:
Adipose autotaxin: a novel link between obesity and cardiovascular disease
脂肪自分泌运动因子:肥胖与心血管疾病之间的新联系
- 批准号:
8820510 - 财政年份:2015
- 资助金额:
$ 0.59万 - 项目类别:
Adipose autotaxin: a novel link between obesity and cardiovascular disease
脂肪自分泌运动因子:肥胖与心血管疾病之间的新联系
- 批准号:
8994168 - 财政年份:2015
- 资助金额:
$ 0.59万 - 项目类别:
Regulation of adipose cells by autotaxin / lysophosphatidic acid signaling
通过自分泌运动因子/溶血磷脂酸信号传导调节脂肪细胞
- 批准号:
8391631 - 财政年份:2010
- 资助金额:
$ 0.59万 - 项目类别:
Regulation of adipose cells by autotaxin / lysophosphatidic acid signaling
通过自分泌运动因子/溶血磷脂酸信号传导调节脂肪细胞
- 批准号:
8043979 - 财政年份:2010
- 资助金额:
$ 0.59万 - 项目类别:
Regulation of adipose cells by autotaxin / lysophosphatidic acid signaling
通过自分泌运动因子/溶血磷脂酸信号传导调节脂肪细胞
- 批准号:
8198376 - 财政年份:2010
- 资助金额:
$ 0.59万 - 项目类别:
Regulation of adipose cells by autotaxin / lysophosphatidic acid signaling
通过自分泌运动因子/溶血磷脂酸信号传导调节脂肪细胞
- 批准号:
8597407 - 财政年份:2010
- 资助金额:
$ 0.59万 - 项目类别:
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