Characterizing Hemisphere-Specific Deficits in Bimanual Motor Control After Stroke

描述中风后双手运动控制中半球特异性缺陷的特征

• 批准号: 9760396
• 负责人: Rini Varghese
• 金额: $ 3.73万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2021-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9760396
• 关键词: Affect; Anisotropy; Bilateral; Brain scan; Cerebral Dominance; Cerebral hemisphere; Chronic; Corpus Callosum; Coupling; Development; Diffusion; Disadvantaged; Exhibits; Feedback; Goals; Individual; Left; Lesion; Limb structure; Measures; Mediating; Movement; Nervous System Trauma; Neurological rehabilitation; Phase; Research; Role; Side; Stroke; Structure; Training; Training Programs; arm; base; behavioral study; chronic stroke; hemisphere damage; motor control; motor deficit; neurobehavioral; patient subsets; post stroke; response; stroke survivor; therapy development; two-dimensional

PROJECT SUMMARY Understanding the specific roles of the cerebral hemispheres for the control of bilateral movement is an important goal of motor control research with implications for rehabilitation of neurological injury, especially stroke. For instance, behavioral studies indicate that individuals with right hemisphere damage (RHD) exhibit a diminished response to bilateral arm training compared to those with left hemisphere damage (LHD). Additionally, those with RHD are less likely to use their more-affected arm alone or bilaterally with their less-affected arm. In order to better understand the peculiar disadvantage suffered by individuals with RHD, this proposal seeks to examine hemisphere-specific deficits in interlimb coordination during bimanual tasks by investigating an empirical phenomenon known as interlimb coupling (IC). We will first characterize IC for discrete bimanual aiming tasks in young control subjects. Based on this characterization, we will identify bimanual task conditions that elicit strong IC in control subjects and quantify and compare IC deficits for these conditions between individuals with LHD and RHD. Lastly, on the basis of the strong evidence supporting the role of the corpus callosum in mediating interlimb interactions, we will quantify corpus callosal microstructure, quantify associations of this measure with our measures of IC, and compare this relationship between chronic stroke survivors with LHD and RHD. Hypothesis: According to the Dynamic Dominance Hypothesis, the two hemispheres assume specialized but complementary roles in the two-component control of unimanual movement, with the left hemisphere responsible for feedforward mechanisms of control (in the early phase of movement), while the right hemisphere is responsible for feedback-mediated, end-point stabilization (in the late phase of movement).16 We hypothesize that interlimb coupling during bimanual tasks is influenced by hemispheric specialization. Thus, after a stroke, deficits in IC, will be dissociable between individuals with left and right hemisphere damage, with LHD exhibiting IC deficits in the early and RHD exhibiting IC deficits in the late phase of bilateral movements. Aim 1: Characterize interlimb coupling during discrete bimanual aiming tasks. Aim 2: Determine the influence of the side of stroke lesion on interlimb coupling. Aim 3: Investigate the relationship between corpus callosum microstructure and interlimb coupling. Studying fundamental neurobehavioral mechanisms and the identification of hemisphere-specific deficits of bimanual movements after stroke is a necessary first step toward the development of interventions to remediate these deficits. Successful accomplishment of these aims will advance our understanding of hemisphere-specific mechanisms, and by doing so, lay groundwork for the development of targeted training programs for stroke survivors with left- or right-hemisphere damage.

项目摘要 了解大脑半球控制双侧运动的具体作用是一个重要的 运动控制研究的目标与神经损伤，特别是中风康复的影响。为 例如，行为研究表明，患有右半球损伤（RHD）的个体表现出减少的 与左半球损伤（LHD）的人相比，双侧手臂训练的反应。而且那些 患风湿性心脏病的患者不太可能单独使用患侧手臂或双侧使用患侧手臂。 为了更好地了解风湿性心脏病患者所面临的特殊劣势，本提案旨在研究 双手作业时肢体间协调的半球特异性缺陷 这一现象称为肢间耦合（IC）。我们将首先表征离散双手瞄准任务的IC， 年轻的对照组基于这一特征，我们将确定双手任务条件， IC在对照受试者和量化和比较IC赤字为这些条件之间的个人与LHD 和RHD。最后，在有力证据支持胼胝体介导的基础上， 肢体间的相互作用，我们将量化胼胝体的微观结构，量化这一措施与 我们的措施IC，并比较这种关系的慢性中风幸存者与LHD和RHD。 假设：根据动态优势假设，两个半球假设专门化， 在单手运动的双成分控制中的互补作用，左半球负责 对于前馈控制机制（在运动的早期阶段），而右半球是 负责反馈介导的终点稳定（在运动后期）。 我们假设双手操作时的肢体间耦合是受大脑半球特化的影响。因此，在本发明中， 中风后，IC缺陷在左半球和右半球受损的个体之间是不可分离的， LHD在双侧运动的早期表现出IC缺陷，RHD在双侧运动的晚期表现出IC缺陷。 目的1：在离散双手瞄准任务期间表征肢体间耦合。 目的2：确定卒中病变侧对肢体间耦合的影响。 目的3：探讨胼胝体微结构与肢间耦合的关系。 研究基本的神经行为机制和识别大脑半球特异性缺陷， 中风后的双手运动是发展干预措施的必要的第一步， 弥补这些缺陷。这些目标的成功实现将促进我们对 大脑半球特异性机制，并通过这样做，为有针对性的训练奠定基础 为左半球或右半球受损的中风幸存者提供的项目。