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Mechanisms of sensorineural hearing loss: secreted factors

感音神经性听力损失的机制：分泌因素

基本信息

批准号：
9759905
负责人：
Konstantina M Stankovic
金额：
$ 42.5万
依托单位：
MASSACHUSETTS EYE AND EAR INFIRMARY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-13 至 2021-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9759905
关键词：
Acoustic Nerve Acoustic Neuroma Acoustic Trauma Acute Affect Aminoglycosides Anatomy Animal Model Animals Apoptosis Auditory Autopsy Biochemical Cavia Chronic Clinical Cochlea Computers Core Facility Custom Data Ear Educational process of instructing Enzyme-Linked Immunosorbent Assay Equilibrium Event Eye FDA approved FGF2 gene Facial paralysis Floor Functional disorder Future Gene Targeting Generations Hair Cells Health care facility Hearing Hearing Tests Histologic Hospital Referrals Hospitals Human Immune Immunohistochemistry In Vitro Internet Intracranial Neoplasms Ipsilateral Laboratories Light Linear Regressions Liquid substance Massachusetts Measurement Measures Mechanics Mediating Mediator of activation protein MicroRNAs Modeling Molecular Mus Nerve compression syndrome Neurons Non-Malignant Outer Hair Cells Pathology Pathway interactions Patient Care Patients Personal Computers Pharmaceutical Preparations Pharmacology Pharmacotherapy Physiological Pilot Projects Proteins Radiology Specialty Research Resources Reverse Transcriptase Polymerase Chain Reaction Role Sampling Schwann Cells Secondary to Sensorineural Hearing Loss Severities Signal Transduction Synapses System TNF gene Temporal bone structure Testing Time Tinnitus Toxic effect Translations Vestibular Nerve Viral Viral Vector Work animal care clinical Diagnosis clinically relevant deafness design experimental study hearing impairment in vivo insight medical schools member neurophysiology normal hearing novel otoacoustic emission ototoxicity prevent square foot targeted treatment tumor necrosis factor-alpha inhibitor

项目摘要

Resources Facilities The Eaton-Peabody Laboratories (EPL) at the Massachusetts Eye and Ear Infirmary (MEEI) occupies ~10,000 sq ft, 2500 sq ft and 2000 sq ft on floors 4, 6 and 3, respectively. The laboratory is fully equipped for neurophysiological, anatomic, histologic, immunohistochemical and molecular studies. Clinical The Masschusetts Eye and Ear Infirmary is a tertiary referral hospital and a teaching affiliate of Harvard Medical School. The hospital has state of the art facilities for care of patients with hearing loss. Animal There is a fully equipped animal care facility at MEEI, which includes two animal rooms (~400 sq. ft. each) reserved for use by members of EPL. The facility also includes rooms for acute and chronic animals. Computer Personal computers with internet access are available throughout the EPL. Computer facilities are maintained by full time computer programmer and systems analysts. Office The P.I. has a 200 sq ft office at MEEI adjacent to her dedicated laboratory space of ~1000 sq ft. Other The P.I. has access to the viral core facility at Massachusetts Eye and Ear. The core facility is fully equipped for customized viral vector design.

资源设施位于马萨诸塞州眼耳医院（MEEI）的伊顿-皮博迪实验室（EPL）占地约10，000 第四、六及三层分别为2500平方呎、2000平方呎及2000平方呎。实验室设备齐全，神经生理学、解剖学、组织学、免疫组织化学和分子研究。临床马萨诸塞州眼耳医院是一家三级转诊医院，也是哈佛大学的教学附属医院医学院该医院拥有最先进的设施，用于照顾听力损失患者。动物 MEEI有一个设备齐全的动物护理设施，包括两个动物房（约400平方米）。英尺（每项）仅供EPL成员使用。该设施还包括急性和慢性动物的房间。计算机整个EPL都提供可上网的个人电脑。计算机设施得到维护全职计算机程序员和系统分析师。办公室私家侦探在MEEI有一个200平方英尺的办公室，毗邻她的专用实验室空间约1000平方英尺。其他私家侦探能进入马萨诸塞州眼耳中心的病毒核心设施核心设施配套齐全用于定制病毒载体设计。