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Mechanisms of sensorineural hearing loss: secreted factors

感音神经性听力损失的机制：分泌因素

基本信息

批准号：
9221084
负责人：
Konstantina M Stankovic
金额：
$ 42.44万
依托单位：
MASSACHUSETTS EYE AND EAR INFIRMARY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-13 至 2021-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9221084
关键词：
Acoustic Nerve Acoustic Neuroma Acoustic Trauma Acute Affect Aminoglycosides Anatomy Animal Model Animals Apoptosis Audiometry Auditory Cavia Chronic Clinical Computers Conditioned Culture Media Core Facility Data Diagnosis Ear Educational process of instructing Enzyme-Linked Immunosorbent Assay Equilibrium Event Eye FDA approved FGF2 gene Facial paralysis Floor Functional disorder Future Gene Targeting Generations Hair Cells Hearing Histologic Hospital Referrals Hospitals Human Immune Immunohistochemistry In Vitro Internet Intracranial Neoplasms Ipsilateral Laboratories Light Linear Regressions Liquid substance Massachusetts Measurement Measures Mechanics Mediating Mediator of activation protein MicroRNAs Modeling Molecular Mus Nerve compression syndrome Neurons Non-Malignant Outer Hair Cells Pathology Pathway interactions Patient Care Patients Personal Computers Pharmaceutical Preparations Pharmacotherapy Pilot Projects Proteins Research Resources Reverse Transcriptase Polymerase Chain Reaction Role Sampling Schwann Cells Secondary to Sensorineural Hearing Loss Severities Signal Transduction Synapses System TNF gene Temporal bone structure Testing Time Tinnitus Toxic effect Translations Vestibular Nerve Viral Viral Vector Work animal care clinically relevant deafness design hearing impairment in vivo inhibitor/antagonist insight medical schools member neurophysiology novel otoacoustic emission ototoxicity prevent research study square foot targeted treatment tumor

项目摘要

Resources Facilities The Eaton-Peabody Laboratories (EPL) at the Massachusetts Eye and Ear Infirmary (MEEI) occupies ~10,000 sq ft, 2500 sq ft and 2000 sq ft on floors 4, 6 and 3, respectively. The laboratory is fully equipped for neurophysiological, anatomic, histologic, immunohistochemical and molecular studies. Clinical The Masschusetts Eye and Ear Infirmary is a tertiary referral hospital and a teaching affiliate of Harvard Medical School. The hospital has state of the art facilities for care of patients with hearing loss. Animal There is a fully equipped animal care facility at MEEI, which includes two animal rooms (~400 sq. ft. each) reserved for use by members of EPL. The facility also includes rooms for acute and chronic animals. Computer Personal computers with internet access are available throughout the EPL. Computer facilities are maintained by full time computer programmer and systems analysts. Office The P.I. has a 200 sq ft office at MEEI adjacent to her dedicated laboratory space of ~1000 sq ft. Other The P.I. has access to the viral core facility at Massachusetts Eye and Ear. The core facility is fully equipped for customized viral vector design.

资源