Identifying causes and consequences of centrosome amplification in cancer
Identifying causes and consequences of centrosome amplification in cancer
批准号:
9534556
负责人:
RYAN Austin DENU
金额:
$3.67万
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
已结题
起止时间:
2016-09-01 至 2020-08-31
关键词:
AddressAffectAneuploidyBreast Cancer PatientCause of DeathCell LineCell divisionCell fusionCell physiologyCellsCellular StructuresCentriolesCentrosomeChromosomal InstabilityChromosomesCiliaCiliary Motility DisordersClinicalCoupledCytokinesisDefectDiseaseDrug TargetingEnzymesEpigenetic ProcessFailureGene MutationGenesGenetic MaterialsGenetic VariationGoalsGrowthHumanInduced MutationInterphaseKnowledgeLeadLearningMalignant NeoplasmsMass Spectrum AnalysisMediatingMicrocephalyMicrotubule-Organizing CenterMicrotubulesMitosisMitotic spindleMolecularMutateMutationOutcomePLK1 genePathway interactionsPatient-Focused OutcomesPhenotypePolycystic Kidney DiseasesPositioning AttributePrevalenceProcessPrognostic FactorProliferatingProteinsRegulationReportingResearchRetinal DiseasesRoleShapesSignal TransductionSourceTestingTetracyclinesTissue MicroarrayVariantcancer cellcancer typecell behaviorcell motilitychemical geneticsgenetic approachhuman diseaseimprovedinsightmalignant breast neoplasmmigrationneoplastic cellnovelnovel therapeuticsoverexpressionphosphoproteomicsprognosticprognostic valueprotein complexrho GTP-Binding Proteinstherapeutic targettumor
中文摘要
项目摘要/摘要
英文摘要
PROJECT SUMMARY / ABSTRACT
Cancer is the second leading cause of death in the U.S., and novel therapeutics are of great need.
Centrosomes are cellular microtubule organizing centers that are important for the faithful division of
chromosomes during mitosis and are commonly dysregulated in cancer. Most human tumors have cells with
centrosome amplification, or an abnormally elevated number of centrosomes. As a result of centrosome
amplification, cancer cells can undergo asymmetric cell division, leading to chromosomal instability and
aneuploidy, which is a source of genetic diversity that allows cancer to evolve and evade therapies. However, it
is unclear how centrosome amplification arises, how it affects patient outcomes, and how it affects migration
and metastatic potential.
The overarching goal of this proposed research is to understand how centrosomes are dysregulated in cancer
and to investigate the subsequent cellular and clinical consequences. The research proposed herein will
enhance our knowledge of centrosome amplification in cancer, especially cancer cell division and migration,
and potentially identify novel ways to target cancer cells with centrosome amplification.
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