Evaluating New Nicotine Standards for Cigarettes - Core C

核心C -生物统计学和数据管理 生物统计和数据管理核心提供广泛的统计服务，以支持 三个项目。核心将提供有关实验设计的建议-如终点的选择， 可能的分层、考虑和计算样本量和统计功效。核心是 负责数据管理的所有方面，在一个安全的中央数据库，重点是数据 诚信和质量。核心小组将制定计划，并以符合标准的格式进行专家统计分析。 项目之间使用的技术是最先进的实践。核心还将促进数据共享 项目之间的项目以及一般科学界遵循NIH的指导方针。 核心由一名生物统计学家担任方案经理（数据经理）和三名高级 与项目研究者有日常工作关系的经验丰富的生物统计学家。核心 生物统计学家一直是拟议计划制定的一个组成部分， 与这组研究人员一起研究了目前CENIC拨款的最后4-5年。 生物统计和数据管理核心的主要目标是为科学和 通过充分参与中心的活动，促进中心的运作。核心统计员具有广泛的长期 实验设计、数据收集、数据存储、数据分析和结果解释方面的专业知识 并根据需要加入新的和复杂的统计程序。通过提供专业研究 为每个项目的数据分析活动提供方法和后勤支持，该核心将增强数据 解释和科学生产力。

Core C – Biostatistics and Data Management The Biostatistics and Data Management Core provides a broad array of statistical services in support of the three Projects. The Core will provide advice on experimental design - such as selection of end points and possible stratification, consideration and calculation of sample size and statistical power. The Core is responsible for all aspects of data management in a secure central database with strong emphasis of data integrity and quality. The Core will form plans and perform expert statistical analyses in a format consistent between Projects using techniques that are state of the art in practice. The Core will also facilitate data sharing between projects in the Program as well as the general scientific community following NIH guidelines. The Core is staffed by one biostatistician serving as Protocol Manager (Data Manager) and three highly experienced biostatisticians who have daily working relationships with the Project investigators. The Core biostatisticians have been an integral part in the development of the proposed Program and have participated with this group of investigators the last 4-5 years of this current CENIC grant. The primary objective of the Biostatistics and Data Management Core is to contribute to the science and operation of the center by participating fully in its activities. Core Statisticians have broad long-standing expertise in experimental design, data collection, data storage, data analysis, and interpretation of results incorporating novel and complex statistical procedures as needed. By providing expertise research methodology and logistical support to data analytic activities with each Project, this Core will enhance data interpretation and scientific productivity.