HIV Research Training Program

艾滋病毒研究培训计划

• 批准号: 9889198
• 负责人: Gene D. Morse
• 金额: $ 19.92万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-01 至 2022-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9889198
• 关键词: AIDS prevention; Adherence; Advisory Committees; Antimalarials; Area; Buffaloes; Clinical; Clinical Pharmacology; Complement; Drug Interactions; Drug Kinetics; Educational Curriculum; Faculty; Funding; Government; HIV; Health; Health Sciences; Infant; International; International AIDS; Intervention; Laboratories; Maternal-Fetal Transmission; Medicine; Postdoctoral Fellow; Pregnancy; Prevention Research; Program Evaluation; Research; Research Personnel; Research Training; Secondary to; Structure; Testing; Therapeutic; Therapeutic Equivalency; Training; Training Programs; United States National Institutes of Health; Universities; Vertical Disease Transmission; Zimbabwe; antiretroviral therapy; child bearing; college; hormonal contraception; in utero; novel; prevent; programs; sexual HIV transmission; skills; treatment research; tuberculosis drugs

 DESCRIPTION (provided by applicant): This application is for a HIV Research and Training Program (HRTP) between the University at Buffalo (UB) and the University of Zimbabwe (UZ). The HRTP will build on a recently completed AIDS International HIV Research and Training Program that was focused on re-initiating postgraduate training at the Master's level in HIV clinical pharmacology research at UZ. Scientific breakthroughs in HIV prevention and treatment research have produced evidence suggesting that interventions involving early access to antiretroviral therapy (ART) are highly effective in preventing HIV sexual transmission and vertical transmission during pregnancy, childbearing and delivery. Government and academic leaders in Zimbabwe have identified HIV Clinical Pharmacology Research as a key component of national planning for ARV access and HIV therapeutics to implement these scientific breakthroughs. The UB-UZ HRTP will focus on novel aspects that integrate clinical pharmacology research with: 1) ARV adherence, 2) clinically important pharmacokinetic drug interactions (e.g. anti-tuberculosis drugs, anti- malarials, hormonal contraceptives and traditiona medicines), 3) ARV disposition during pregnancy (secondary to WHO Option B+ implementation) and in infants, and to determine in utero ARV exposure, and 4) bioequivalency testing for generic ARV products prior to widespread implementation. These research areas integrate well with other NIH funded projects and regional capacity building. The HRTP will broaden the training focus to include masters, doctoral and post-doctoral trainees and emphasize a curriculum that provides an HIV Clinical Pharmacology Research Skills Toolbox for HRTP trainees to gain the skillset that will be required to be an independent researcher. HRTP trainees will gain focused clinical pharmacology research training at UB in an internationally recognized HIV Clinical Pharmacology Laboratory that complements the UZ Clinical Pharmacology Laboratory program. The UB-UZ HRTP has strong support from the UZ College of Health Sciences and the Ministry of Health. The HRTP will benefit from an expert Training Advisory Committee and a complement of highly motivated faculty that will provide the curriculum, structured research training and program evaluation that will assure a highly productive, efficient HIV research training initiative.

 描述（由应用程序提供）：此申请是针对布法罗大学（UB）和津巴布韦大学（UZ）的大学（UB）之间的HIV研究与培训计划（HRTP）。 HRTP将建立在最近完成的AIDS国际艾滋病毒研究和培训计划的基础上，该计划的重点是在UZ的HIV HIV临床药理学研究大师级重新生产研究生培训。艾滋病毒预防和治疗研究的科学突破已经产生了证据，表明涉及及早进入抗逆转录病毒疗法（ART）的干预措施在预防艾滋病毒性传播和垂直传播期间非常有效。津巴布韦的政府和学术领导者已将HIV临床药理学研究确定为ARV访问和HIV疗法的国家计划的关键组成部分。实施这些科学突破。 UB-UZ HRTP将重点关注临床药理学研究的新方面：1）ARV依从性，2）临床上重要的药代动力学相互作用（例如，抗结核药物，抗癌症，抗癌症，抗癌症，激素，荷尔蒙避孕药和传统药物）在怀孕期间的选择（3）在妊娠期间（3）选择均可及其在怀孕期间的选择。 ARV暴露和4）在实施宽度之前对通用ARV产品进行生物等效性测试。这些研究领域与其他NIH资助的项目和区域能力建设很好地集成了。 HRTP将扩大培训重点，包括硕士，博士和博士后学员，并强调一项课程，该课程为HRTP受训者提供了HIV临床药理学研究技能工具箱，以获得成为独立研究人员所需的技能。 HRTP受训者将在填写UZ临床药理学实验室计划的国际公认的HIV临床药理学实验室中获得UB的重点临床药理学研究培训。 UB-UZ HRTP得到了UZ卫生科学学院和卫生部的大力支持。 HRTP将受益于专家培训咨询委员会，并获得高度积极进取的教师，该教师将提供课程，结构化的研究培训和计划评估，该课程将假设一项高效，高效的HIV研究培训计划。