HIV Research Training Program

艾滋病毒研究培训计划

• 批准号: 9889198
• 负责人: Gene D. Morse
• 金额: $ 19.92万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-01 至 2022-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9889198
• 关键词: AIDS prevention; Adherence; Advisory Committees; Antimalarials; Area; Buffaloes; Clinical; Clinical Pharmacology; Complement; Drug Interactions; Drug Kinetics; Educational Curriculum; Faculty; Funding; Government; HIV; Health; Health Sciences; Infant; International; International AIDS; Intervention; Laboratories; Maternal-Fetal Transmission; Medicine; Postdoctoral Fellow; Pregnancy; Prevention Research; Program Evaluation; Research; Research Personnel; Research Training; Secondary to; Structure; Testing; Therapeutic; Therapeutic Equivalency; Training; Training Programs; United States National Institutes of Health; Universities; Vertical Disease Transmission; Zimbabwe; antiretroviral therapy; child bearing; college; hormonal contraception; in utero; novel; prevent; programs; sexual HIV transmission; skills; treatment research; tuberculosis drugs

 DESCRIPTION (provided by applicant): This application is for a HIV Research and Training Program (HRTP) between the University at Buffalo (UB) and the University of Zimbabwe (UZ). The HRTP will build on a recently completed AIDS International HIV Research and Training Program that was focused on re-initiating postgraduate training at the Master's level in HIV clinical pharmacology research at UZ. Scientific breakthroughs in HIV prevention and treatment research have produced evidence suggesting that interventions involving early access to antiretroviral therapy (ART) are highly effective in preventing HIV sexual transmission and vertical transmission during pregnancy, childbearing and delivery. Government and academic leaders in Zimbabwe have identified HIV Clinical Pharmacology Research as a key component of national planning for ARV access and HIV therapeutics to implement these scientific breakthroughs. The UB-UZ HRTP will focus on novel aspects that integrate clinical pharmacology research with: 1) ARV adherence, 2) clinically important pharmacokinetic drug interactions (e.g. anti-tuberculosis drugs, anti- malarials, hormonal contraceptives and traditiona medicines), 3) ARV disposition during pregnancy (secondary to WHO Option B+ implementation) and in infants, and to determine in utero ARV exposure, and 4) bioequivalency testing for generic ARV products prior to widespread implementation. These research areas integrate well with other NIH funded projects and regional capacity building. The HRTP will broaden the training focus to include masters, doctoral and post-doctoral trainees and emphasize a curriculum that provides an HIV Clinical Pharmacology Research Skills Toolbox for HRTP trainees to gain the skillset that will be required to be an independent researcher. HRTP trainees will gain focused clinical pharmacology research training at UB in an internationally recognized HIV Clinical Pharmacology Laboratory that complements the UZ Clinical Pharmacology Laboratory program. The UB-UZ HRTP has strong support from the UZ College of Health Sciences and the Ministry of Health. The HRTP will benefit from an expert Training Advisory Committee and a complement of highly motivated faculty that will provide the curriculum, structured research training and program evaluation that will assure a highly productive, efficient HIV research training initiative.

 描述(由申请人提供)：本申请是关于布法罗大学(UB)和津巴布韦大学(UZ)之间的艾滋病毒研究和培训计划(HRTP)的申请。HRTP将建立在最近完成的艾滋病国际艾滋病毒研究和培训计划的基础上，该计划的重点是在UZ重新启动艾滋病毒临床药理学研究硕士水平的研究生培训。艾滋病毒预防和治疗研究的科学突破产生的证据表明，包括及早获得抗逆转录病毒治疗(ART)的干预措施在预防艾滋病毒在怀孕、生育和分娩期间的性传播和垂直传播方面非常有效。津巴布韦政府和学术界领导人已将艾滋病毒临床药理学研究确定为实施这些科学突破的国家抗逆转录病毒治疗和艾滋病毒治疗规划的关键组成部分。UB-UZ HRTP将侧重于将临床药理学研究与以下方面结合在一起的新方面：1)抗逆转录病毒药物的依从性；2)临床重要的药代动力学药物相互作用(如抗结核药物、抗疟疾药物、激素性避孕药和传统药物)；3)抗逆转录病毒药物在孕期和婴儿中的处置；以及4)在广泛实施之前对仿制抗逆转录病毒产品进行生物等效性测试。这些研究领域与美国国立卫生研究院资助的其他项目和区域能力建设很好地结合在一起。HRTP将扩大培训重点，包括硕士、博士和博士后实习生，并强调为HRTP实习生提供艾滋病毒临床药理学研究技能工具箱的课程，以获得成为独立研究人员所需的技能。HRTP学员将在亚利桑那大学一个国际公认的HIV临床药理实验室接受重点临床药理学研究培训，该实验室是对亚利桑那州临床药理实验室计划的补充。UB-UZ HRTP得到了UZ卫生科学学院和卫生部的大力支持。HRTP将受益于一个专家培训咨询委员会和一批积极进取的教职员工，他们将提供课程、结构化研究培训和项目评估，以确保高产出、高效率的艾滋病毒研究培训计划。