FASEB SRC on Matricellular Proteins in Inflammation and Tissue Remodeling

FASEB SRC 对炎症和组织重塑中基质细胞蛋白的影响

• 批准号: 9761800
• 负责人: OLGA I STENINA
• 金额: $ 1.9万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9761800
• 关键词: 20 year old; Adhesions; Age; Aging; Alzheimer' s Disease; Apoptosis; Arthritis; Autoimmunity; Basic Science; Biological Markers; Biological Process; Bloom Syndrome; Cardiovascular Diseases; Cardiovascular system; Cell Adhesion; Cell Adhesion Process; Cell Communication; Cell Cycle Progression; Cell Surface Receptors; Cell physiology; Cells; Clinical; Cockayne Syndrome; Collaborations; Collagen; Complex; Complications of Diabetes Mellitus; Crohn' s disease; Cysteine; DNA Repair; DNA biosynthesis; Data; Defect; Development; Diabetes Mellitus; Diagnosis; Disabled Persons; Discipline; Disease; Dyskeratosis Congenita; Ensure; Enzymes; Extracellular Matrix; Extracellular Matrix Proteins; Extracellular Protein; Extracellular Structure; Eye; Family; Fanconi' s Anemia; Fertilization; Fibrosis; Fostering; Gender; Gene Expression; Genomic Instability; Glaucoma; Goals; Growth Factor; Heart failure; Human Pathology; Hypertension; Immunity; Industry; Infection; Inflammation; International; Kidney Failure; Knowledge; Lead; Link; Macular degeneration; Malignant Neoplasms; Mechanics; Medical; Metabolism; Minority; Molecular; Molecular Machines; Morbidity - disease rate; Neoplasm Metastasis; Ophthalmoplegia; Participant; Peptide Hydrolases; Peripheral Nervous System; Peripheral Vascular Diseases; Phenotype; Physiological; Physiological Processes; Premature aging syndrome; Process; Proteins; RNA Splicing; RNA Transport; Reactive Oxygen Species; Receptor Cell; Recording of previous events; Regulation; Reporting; Reproductive system; Research; Research Personnel; Review Literature; Role; Rothmund-Thomson syndrome; Science; Scientist; Signal Transduction; Stress; Stroke; Structure; Syndrome; System; Tenascin; Therapeutic Agents; Therapeutic Intervention; Thrombospondin 1; Thrombospondins; Tissues; Translational Research; Trichothiodystrophy; Underrepresented Groups; Universities; Vascular remodeling; Washington; Werner Syndrome; Wisconsin; Woman; Work; Xeroderma Pigmentosum; angiogenesis; career development; cell growth regulation; chronic wound; clinical application; design; ethnic minority population; family structure; fibulin; helicase; human disease; innovation; interest; meetings; migration; mortality; neurogenesis; novel; osteopontin; painful neuropathy; periostin; posters; programs; protein complex; racial and ethnic; repaired; response; skeletal dysplasia; supportive environment; symposium; targeted treatment; therapeutic protein; therapeutic target; thrombospondin 4

Abstract The FASEB Scientific Research Conference “Matricellular Proteins in Inflammation and Tissue Remodeling” continues a more than 20-year history of conferences dedicated to matricellular proteins, a family of secreted modulatory adhesion proteins regulating interactions between cells and ECM. Matricellular proteins include a structurally diverse group of extracellular proteins, which regulate a wide array of key cellular processes, including cell adhesion, migration, survival, proliferation, extracellular matrix organization, growth factor and protease regulation, and differentiation. Of importance are emerging data showing key roles for matricellular proteins in diseases through their roles in regulating tissue remodeling, angiogenesis, fibrosis, inflammation, immunity, metabolism, and development. Matricellular proteins are therapeutic targets for multiple diseases, including cardiovascular disease, cancer and metastasis, autoimmunity, neurogenesis and neuropathic pain, ocular diseases including inflammation, glaucoma, and macular degeneration, diabetes and diabetic complications, skeletal dysplasia, and arthritis. The field has evolved from elucidating structure function activities of these complex proteins to identifying roles in diseases and the development of matricellular- targeted therapeutic interventions. The 2019 conference will be the 8th conference dedicated to matricellular proteins. The FASEB SRC “Matricellular Proteins” is unique in that it is the only meeting focusing on the group of matricellular proteins that can bring together researchers, clinicians, and industry representatives from different fields and disciplines, who focus on specific matricellular proteins (thrombospondins, CCNs, SPARC, tenascins, etc.) in various contexts. The aims of the conference are: Aim 1. To bring together researchers with active interests in the structures, functions, and clinical applications of matricellular proteins and to create a forum for free exchange of ideas and new unpublished information among international researchers to ensure continued progress and innovation in the field. Aim 2. To promote translation of research findings into novel clinical therapies. Aim 3. To foster the development of young scientists through dissemination of their work and through meaningful exchanges with established scientists. The conference is designed to assure an appropriate representation of women and minority participants, as well as participation of young investigators and trainees. In addition to the scientific sessions, poster sessions, a career development session, and a “Meet the expert” dinner are planned to facilitate the interactions of trainees and young investigators with established leaders of the field and to provide a friendly and supportive environment for the exchange of scientific ideas.

抽象的 FASEB科学研究会议“炎症和组织重塑中的母细胞蛋白” 延续了20年以上的会议历史，专门用于基质蛋白，一个分泌的家族 调节性粘合剂蛋白调节细胞与ECM之间的相互作用。母细胞蛋白包括 结构上多样的细胞外蛋白质，它们调节了广泛的钥匙细胞过程， 包括细胞依从性，迁移，生存，增殖，细胞外基质组织，生长因子和 蛋白酶调节和分化。重要的是新兴数据显示了矩阵的关键作用 蛋白质通过调节组织重塑，血管生成，纤维化，炎症， 免疫，代谢和发展。母细胞蛋白是多种疾病的热靶标， 包括心血管疾病，癌症和转移，自身免疫性，神经发生和神经性疼痛， 眼部疾病，包括感染，青光眼和黄斑变性，糖尿病和糖尿病 并发症，骨骼发育不良和关节炎。该领域是从阐明结构函数演变而来的 这些复杂蛋白质的活性以鉴定疾病中的作用和基质的发展 有针对性的治疗干预措施。 2019年会议将是专门针对Matrix的第八届会议 蛋白质。 FASEB SRC“矩阵蛋白”的独特之处在于，它是唯一关注组的会议 可以将研究人员，临床医生和行业汇集在一起​​的基质蛋白的代表 不同的领域和学科，他们专注于特定基质蛋白（血小板传播，CCN，SPARC， 在各种情况下）。会议的目的是： 目标1。将研究人员积极兴趣集中在结构，功能和临床应用中 矩阵蛋白质的蛋白质，并创建一个论坛，以免费交换想法和新的未发表信息 在国际研究人员中，以确保该领域的持续进展和创新。 目的2。促进研究结果转化为新型临床疗法。 目标3。通过传播工作和通过 与已建立的科学家进行有意义的交流。 该会议旨在确保适当的妇女和少数群体参与者的代表 以及年轻的调查员和学员的参与。除了科学会议，海报会议， 计划进行职业发展和“见面专家”晚餐，以促进 受训人员和年轻的调查员拥有该领域的既定领导人，并提供友好和支持的 交换科学思想的环境。