FASEB SRC on Matricellular Proteins in Inflammation and Tissue Remodeling

FASEB SRC 对炎症和组织重塑中基质细胞蛋白的影响

• 批准号: 9761800
• 负责人: OLGA I STENINA
• 金额: $ 1.9万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9761800
• 关键词: 20 year old; Adhesions; Age; Aging; Alzheimer' s Disease; Apoptosis; Arthritis; Autoimmunity; Basic Science; Biological Markers; Biological Process; Bloom Syndrome; Cardiovascular Diseases; Cardiovascular system; Cell Adhesion; Cell Adhesion Process; Cell Communication; Cell Cycle Progression; Cell Surface Receptors; Cell physiology; Cells; Clinical; Cockayne Syndrome; Collaborations; Collagen; Complex; Complications of Diabetes Mellitus; Crohn' s disease; Cysteine; DNA Repair; DNA biosynthesis; Data; Defect; Development; Diabetes Mellitus; Diagnosis; Disabled Persons; Discipline; Disease; Dyskeratosis Congenita; Ensure; Enzymes; Extracellular Matrix; Extracellular Matrix Proteins; Extracellular Protein; Extracellular Structure; Eye; Family; Fanconi' s Anemia; Fertilization; Fibrosis; Fostering; Gender; Gene Expression; Genomic Instability; Glaucoma; Goals; Growth Factor; Heart failure; Human Pathology; Hypertension; Immunity; Industry; Infection; Inflammation; International; Kidney Failure; Knowledge; Lead; Link; Macular degeneration; Malignant Neoplasms; Mechanics; Medical; Metabolism; Minority; Molecular; Molecular Machines; Morbidity - disease rate; Neoplasm Metastasis; Ophthalmoplegia; Participant; Peptide Hydrolases; Peripheral Nervous System; Peripheral Vascular Diseases; Phenotype; Physiological; Physiological Processes; Premature aging syndrome; Process; Proteins; RNA Splicing; RNA Transport; Reactive Oxygen Species; Receptor Cell; Recording of previous events; Regulation; Reporting; Reproductive system; Research; Research Personnel; Review Literature; Role; Rothmund-Thomson syndrome; Science; Scientist; Signal Transduction; Stress; Stroke; Structure; Syndrome; System; Tenascin; Therapeutic Agents; Therapeutic Intervention; Thrombospondin 1; Thrombospondins; Tissues; Translational Research; Trichothiodystrophy; Underrepresented Groups; Universities; Vascular remodeling; Washington; Werner Syndrome; Wisconsin; Woman; Work; Xeroderma Pigmentosum; angiogenesis; career development; cell growth regulation; chronic wound; clinical application; design; ethnic minority population; family structure; fibulin; helicase; human disease; innovation; interest; meetings; migration; mortality; neurogenesis; novel; osteopontin; painful neuropathy; periostin; posters; programs; protein complex; racial and ethnic; repaired; response; skeletal dysplasia; supportive environment; symposium; targeted treatment; therapeutic protein; therapeutic target; thrombospondin 4

Abstract The FASEB Scientific Research Conference “Matricellular Proteins in Inflammation and Tissue Remodeling” continues a more than 20-year history of conferences dedicated to matricellular proteins, a family of secreted modulatory adhesion proteins regulating interactions between cells and ECM. Matricellular proteins include a structurally diverse group of extracellular proteins, which regulate a wide array of key cellular processes, including cell adhesion, migration, survival, proliferation, extracellular matrix organization, growth factor and protease regulation, and differentiation. Of importance are emerging data showing key roles for matricellular proteins in diseases through their roles in regulating tissue remodeling, angiogenesis, fibrosis, inflammation, immunity, metabolism, and development. Matricellular proteins are therapeutic targets for multiple diseases, including cardiovascular disease, cancer and metastasis, autoimmunity, neurogenesis and neuropathic pain, ocular diseases including inflammation, glaucoma, and macular degeneration, diabetes and diabetic complications, skeletal dysplasia, and arthritis. The field has evolved from elucidating structure function activities of these complex proteins to identifying roles in diseases and the development of matricellular- targeted therapeutic interventions. The 2019 conference will be the 8th conference dedicated to matricellular proteins. The FASEB SRC “Matricellular Proteins” is unique in that it is the only meeting focusing on the group of matricellular proteins that can bring together researchers, clinicians, and industry representatives from different fields and disciplines, who focus on specific matricellular proteins (thrombospondins, CCNs, SPARC, tenascins, etc.) in various contexts. The aims of the conference are: Aim 1. To bring together researchers with active interests in the structures, functions, and clinical applications of matricellular proteins and to create a forum for free exchange of ideas and new unpublished information among international researchers to ensure continued progress and innovation in the field. Aim 2. To promote translation of research findings into novel clinical therapies. Aim 3. To foster the development of young scientists through dissemination of their work and through meaningful exchanges with established scientists. The conference is designed to assure an appropriate representation of women and minority participants, as well as participation of young investigators and trainees. In addition to the scientific sessions, poster sessions, a career development session, and a “Meet the expert” dinner are planned to facilitate the interactions of trainees and young investigators with established leaders of the field and to provide a friendly and supportive environment for the exchange of scientific ideas.

摘要 FASEB科学研究会议“炎症和组织重塑中的基质细胞蛋白质” 延续了20多年的会议历史，致力于matricellular蛋白，一个家庭的分泌 调节细胞和ECM之间相互作用的调节粘附蛋白。基质细胞蛋白包括 结构多样化的细胞外蛋白质组，调节多种关键细胞过程， 包括细胞粘附、迁移、存活、增殖、细胞外基质组织、生长因子和 蛋白酶调节和分化。重要的是，新出现的数据显示， 蛋白质通过它们在调节组织重塑、血管生成、纤维化、炎症 免疫、新陈代谢和发育。基质细胞蛋白是多种疾病的治疗靶点， 包括心血管疾病、癌症和转移、自身免疫、神经发生和神经性疼痛， 眼部疾病，包括炎症、青光眼和黄斑变性、糖尿病和糖尿病 并发症、骨骼发育不良和关节炎。该领域已经从阐明结构功能 这些复合蛋白的活性，以确定在疾病和基质细胞的发展中的作用， 有针对性的治疗干预。2019年会议将是第8届会议致力于matricellular proteins. FASEB SRC“基质细胞蛋白质”是独一无二的，因为它是唯一的会议集中在该组 的研究人员，临床医生和行业代表， 不同的领域和学科，谁专注于特定的基质细胞蛋白质（血小板反应蛋白，CCN，β， 生腱蛋白等）in various不同context上下文.会议的目的是： 目标1.汇集对结构，功能和临床应用感兴趣的研究人员 并创建一个论坛，供自由交流思想和新的未发表的信息 国际研究人员之间的合作，以确保该领域的持续进步和创新。 目标2.促进将研究成果转化为新的临床疗法。 目标3.通过传播青年科学家的工作成果， 与知名科学家进行有意义的交流。 会议旨在确保妇女和少数民族与会者的适当代表性， 以及青年调查员和受训人员的参与。除了科学会议，海报会议， 计划举办职业发展会议和“会见专家”晚宴，以促进 学员和年轻的调查人员与该领域的既定领导人，并提供友好和支持 科学思想交流的环境。