FASEB SRC on Protein Lipidation: Enzymology, Signaling and Therapeutics

项目摘要/摘要 蛋白质脂化是细胞功能的中心过程。脂蛋白在许多 人类疾病包括癌症、传染病和与年龄相关的疾病。我们请求拨款以部分 支持美国实验生物学联合会(FASE B)关于“蛋白质”的会议 脂肪作用：酶学、信号和治疗学“将于2019年7月7日至7月12日在圣彼得堡举行。 博纳文杰大学，纽约州奥利恩。从历史上看，这次会议将不同领域的科学家聚集在一起 从蛋白质的酰化、前烯基化和后烯基化处理的机制和后果来看， 细胞内脂类的合成和运输，以及蛋白质-脂相互作用对细胞的重要性 特化膜结构域中的信号传递。这次会议是世界上唯一一个国际会议场所， 但密切相关的话题会被详细讨论，这是许多科学家的首选。正如田野所做的那样 在过去的14年里，它已经成为高度跨学科的会议，这一独特的会议允许 来自不同专业领域的科学家，从合成化学到临床医学，即将到来 在一起，讨论新的想法，形成新的合作。我们确认的主讲人是弗兰克 麦考密克，他将发表题为《瞄准RAS和 RAS倡议“。会议围绕四个相互关联的主题组织。首先，它将展示最近的 蛋白质脂质修饰相关酶的结构生物学和酶学研究进展。第二，新 关于脂质修饰在各种生理过程和疾病中的作用的研究进展将 报告的疾病包括癌症、传染病和与年龄有关的疾病。第三，新方法论 将介绍蛋白质脂化和脂化蛋白质的研究。最后，最近的治疗努力针对 蛋白质的脂肪作用将被报道。将有9场会议和36名演讲者，其中包括11场简短的演讲。毕业生 学生和博士后研究员将发表三分之二的简短演讲，另外三分之一的演讲将由New 调查人员。我们还将包括10-15名学生和博士后的研究快照 带海报但未被选为主节目简短演讲的研究员将被邀请发表2 一分钟的电梯推介。为了进一步增加我们对学生和博士后研究员的影响，另外两个 将举办各种活动，包括职业发展会议和专家见面会 包括化学、细胞生物学、结构生物学和动物研究在内的四个领域将回答问题。 本次会议申请的资金将主要用于支持研究生和博士后的旅行。 提供赠款，并支持青年调查员和届会主席出席会议。

PROJECT SUMMARY/ABSTRACT Protein lipidation is a central process in cellular function. Lipidated proteins play critical roles in numerous human diseases including cancer, infectious disease and age-related disorders. We request funds to partially support the Federation of American Societies of Experimental Biology (FASEB) conference on “Protein Lipidation: Enzymology, Signaling and Therapeutics” that will be held from July 7 – July 12, 2019 at St. Bonaventure University, Olean, NY. Historically, this meeting has brought together scientists in fields ranging from mechanisms and consequences of acylation, prenylation, and post-prenylation processing of proteins, the synthesis and transport of intracellular lipids, and the importance of protein-lipid interactions for cellular signaling in specialized membrane domains. This meeting is the only international venue where these broad but closely interrelated topics are discussed at length and is the first choice for many scientists. As the field has grown over the past fourteen years, it has become highly interdisciplinary and this unique meeting allows scientists from different areas of specialization, ranging from synthetic chemistry to clinical medicine, to come together and discuss new ideas and form new collaborations. Our confirmed keynote speaker is Frank McCormick, University of California at San Francisco who will present a lecture entitled “Targeting Ras and the Ras Initiative”. The conference is organized around four interrelated themes. First, it will showcase recent advances in structural biology and enzymology of enzymes involved in protein lipid modification. Second, new developments concerning the roles of lipid modifications in various physiological processes and diseases will be reported including cancer, infectious disease and age-related disorders. Third, new methodologies for studying protein lipidation and lipidated proteins will be presented. Finally, recent therapeutic efforts targeting protein lipidation will be reported. There will be 9 sessions and 36 speakers including 11 short talks. Graduate students and postdoctoral fellows will give two-thirds of the short talks, with the other third given by new investigators. We will also include a “Research Snapshots” session in which 10-15 students and postdoctoral fellows who brought posters but were not selected for short talks in the main program will be invited to give a 2 minute elevator pitch. To further increase our impact on students and postdoctoral fellows, two additional events will be held including a career development session and a meet-the-expert session where experts in four areas including chemistry, cell biology, structural biology and animal-based research will answer questions. The funds requested for this meeting will be used primarily to support graduate student and postdoc travel grants and to support the attendance of young investigators and session chairs.