FASEB SRC on Protein Lipidation: Enzymology, Signaling and Therapeutics

FASEB SRC 关于蛋白质脂化：酶学、信号传导和治疗

• 批准号: 9761619
• 负责人: MARK D DISTEFANO
• 金额: $ 0.48万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-03 至 2020-06-02
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9761619
• 关键词: Acylation; Address; American; Animals; Area; Asia; Australia; Biochemistry; Biology; California; Canada; Cell physiology; Cellular biology; Chemistry; Clinical Medicine; Collaborations; Communicable Diseases; Communities; Data; Development; Disease; Elevator; Enzymatic Biochemistry; Enzymes; Equilibrium; Europe; Event; Fees; Funding; Government; Grant; Hearing; Industry; International; Intracellular Transport; Knowledge; Lead; Left; Length; Letters; Lipids; Malignant Neoplasms; Membrane; Mentors; Methodological Studies; Modification; Participant; Physiological Processes; Play; Postdoctoral Fellow; Process; Protein Biosynthesis; Proteins; Reporting; Research; Research Personnel; Role; San Francisco; Scientist; Senior Scientist; Signal Transduction; Slide; Societies; Students; Synthesis Chemistry; Therapeutic; Training; Travel; Underrepresented Groups; United States National Institutes of Health; Universities; Woman; Work; Writing; age related; base; career development; effective therapy; follow-up; graduate student; human disease; improved; interest; lectures; meetings; member; men; next generation; post-doctoral training; posters; prenylation; professor; programs; structural biology; student training; summer research; symposium

PROJECT SUMMARY/ABSTRACT Protein lipidation is a central process in cellular function. Lipidated proteins play critical roles in numerous human diseases including cancer, infectious disease and age-related disorders. We request funds to partially support the Federation of American Societies of Experimental Biology (FASEB) conference on “Protein Lipidation: Enzymology, Signaling and Therapeutics” that will be held from July 7 – July 12, 2019 at St. Bonaventure University, Olean, NY. Historically, this meeting has brought together scientists in fields ranging from mechanisms and consequences of acylation, prenylation, and post-prenylation processing of proteins, the synthesis and transport of intracellular lipids, and the importance of protein-lipid interactions for cellular signaling in specialized membrane domains. This meeting is the only international venue where these broad but closely interrelated topics are discussed at length and is the first choice for many scientists. As the field has grown over the past fourteen years, it has become highly interdisciplinary and this unique meeting allows scientists from different areas of specialization, ranging from synthetic chemistry to clinical medicine, to come together and discuss new ideas and form new collaborations. Our confirmed keynote speaker is Frank McCormick, University of California at San Francisco who will present a lecture entitled “Targeting Ras and the Ras Initiative”. The conference is organized around four interrelated themes. First, it will showcase recent advances in structural biology and enzymology of enzymes involved in protein lipid modification. Second, new developments concerning the roles of lipid modifications in various physiological processes and diseases will be reported including cancer, infectious disease and age-related disorders. Third, new methodologies for studying protein lipidation and lipidated proteins will be presented. Finally, recent therapeutic efforts targeting protein lipidation will be reported. There will be 9 sessions and 36 speakers including 11 short talks. Graduate students and postdoctoral fellows will give two-thirds of the short talks, with the other third given by new investigators. We will also include a “Research Snapshots” session in which 10-15 students and postdoctoral fellows who brought posters but were not selected for short talks in the main program will be invited to give a 2 minute elevator pitch. To further increase our impact on students and postdoctoral fellows, two additional events will be held including a career development session and a meet-the-expert session where experts in four areas including chemistry, cell biology, structural biology and animal-based research will answer questions. The funds requested for this meeting will be used primarily to support graduate student and postdoc travel grants and to support the attendance of young investigators and session chairs.

项目总结/摘要 蛋白质脂化是细胞功能的中心过程。脂化蛋白质在许多生物学过程中起着关键作用。 人类疾病，包括癌症、传染病和与年龄相关的疾病。我们要求资金部分用于 支持美国实验生物学学会联合会（FASEB）关于“蛋白质”的会议 脂质化：酶学，信号传导和治疗“将于2019年7月7日至7月12日在St. 博纳文图尔大学，纽约州奥利安。从历史上看，这次会议汇集了科学家在各个领域， 从蛋白质的酰化、异戊烯化和异戊烯化后加工的机制和结果来看， 细胞内脂质的合成和转运，以及蛋白质-脂质相互作用对细胞的重要性 在专门的膜结构域中的信号传导。这次会议是唯一的国际场所，这些广泛的 但密切相关的主题进行了详细讨论，是许多科学家的首选。随着该领域的 在过去的14年里，它已经成为高度跨学科的，这一独特的会议允许 来自不同专业领域的科学家，从合成化学到临床医学， 一起讨论新的想法，形成新的合作。我们确定的主讲人是弗兰克 McCormick博士，加州大学旧金山分校弗朗西斯科的教授，他将做一个题为“瞄准Ras和 拉斯倡议”。会议围绕四个相互关联的主题组织。首先，它将展示最近 蛋白质脂质修饰酶的结构生物学和酶学进展。二是新 关于脂质修饰在各种生理过程和疾病中的作用的发展将 包括癌症、传染病和与年龄有关的疾病。第三， 研究蛋白质脂化和脂化蛋白质将被呈现。最后，最近的治疗努力， 将报告蛋白质脂化。将有9个会议和36个发言者，包括11个简短的会谈。研究生 学生和博士后研究员将提供三分之二的简短演讲，另外三分之一由新的 investigators.我们还将包括一个“研究快照”会议，其中10-15名学生和博士后 带海报但未被选入主节目的研究员将被邀请在主节目中做一个2 一分钟电梯演讲为了进一步提高我们对学生和博士后研究员的影响，另外两个 将举行的活动包括职业发展会议和专家会议， 包括化学、细胞生物学、结构生物学和动物研究在内的四个领域将回答问题。 本次会议申请的资金将主要用于支持研究生和博士后的旅行 赠款并支持年轻的调查员和会议主席出席会议。