Sequencing and Genotyping in Diverse Populations: Who Wants What Back (and When)?

项目总结 北海岸精准医学会议是一年一度的全国中型会议系列会议，在 俄亥俄州克利夫兰。该系列会议旨在成为持续教育和交流的场所。 与快速发展和高度跨学科的前景相关的科学思想，即精确医学 研究。每次会议的议题都与由 国家研究项目的重点是精准医学。2018年大会是一次研讨会，将重点放在 关于在临床和研究环境中返回基因组结果的相关问题，重点是多样化 人口。会议将以传统形式组织，邀请各国代表发言 从返回研究结果的问题到不同文化背景的参与者和家庭等主题的专家 成员，将不同的患者和参与者群体纳入临床测序证据- 生成研究(CSER)联盟和精密医学转基因技术(TOPMed)计划， 药物基因组学指导的剂量和种族/民族，用于返回结果的策略等。2019年和 超越会议主题正在考虑来自以前的研讨会与会者和准确的趋势 医学研究。奇数年会议包括一个研讨会部分，该部分之前 从电子健康记录中提取覆盖的结果和暴露变量。未来研讨会的主题是 考虑的问题包括多组学的整合、不同人群的药物反应、药物基因组学 临床实施、癌症精准医学、数据共享和知情同意以及APP的使用 用于招募、诊断、随访和治疗。我们这个系列会议的第二个主要目标是 促进生物医学劳动力的多样性。众所周知，从培训到正教授的管道 对于生物医学研究中的女性来说是漏洞百出的，而对代表不足的少数族裔来说，管道实际上是 根本不存在。从国家和地方来源来看，我们审查妇女和代表不足的少数民族 每个受邀的演讲者机会，从而提供宝贵的职业货币和网络机会。我们 还将鼓励妇女和任职人数不足的少数群体，特别是实习生一级参加和 参加这一系列会议，以激发人们以从事精准医学研究为职业的兴趣。总的来说， 北海岸精准医学会议系列是对全国会议的宝贵补充 景观，凭借其独特的地理位置和对参与者的低成本，将成为一个重要的教育 随着精准医学研究的认真加速，这是一个机遇。

PROJECT SUMMARY The North Coast Conference on Precision Medicine is a national annual mid-sized conference series held in Cleveland, Ohio. The conference series aims to serve as a venue for the continuing education and exchange of scientific ideas related to the rapidly evolving and highly interdisciplinary landscape that is precision medicine research. The topics for each conference coincide with the national conversation and research agenda set by national research programs focused on precision medicine. The 2018 conference is a symposium that will focus on issues related to return of genomic results both in clinical and research settings with an emphasis on diverse populations. The conference will be organized as a traditional format with invited speakers from among national experts for topics ranging from issues returning research results to culturally diverse participants and family members, inclusion of diverse patient and participant populations in the Clinical Sequencing Evidence- Generating Research (CSER) consortium and the Trans-Omics for Precision Medicine (TOPMed) Program, pharmacogenomics-guided dosing and race/ethnicity, strategies used to return results, among others. 2019 and beyond conference topics are being considered from previous symposia attendees and trends in precision medicine research. Odd-numbered year conferences include a workshop component that has previously covered outcome and exposure variable extraction from electronic health records. Future workshop topics being considered include integration of multiple ‘omics, drug response in different populations, pharmacogenomics clinical implementation, precision medicine in cancer, data sharing and informed consent, and the use of apps for recruitment, diagnosis, follow-up, and treatment. Our second major objective of this conference series is the promotion of diversity in the biomedical workforce. It is well-known that the pipeline from training to full professor for women in biomedical research is leaky whereas the pipeline for under-represented minorities is practically non-existent. Drawing from national and local sources, we vet women and under-represented minorities for every invited speaker opportunity, thereby providing valuable career currency and networking opportunities. We will also encourage women and under-represented minorities, particularly at the trainee level, to attend and participate in this conference series to spur interest in pursuing precision medicine research as a career. Overall, the North Coast Conference on Precision Medicine series is a valuable addition to the national conference landscape, and with its unique location and low cost to participants, will serve as an important educational opportunity as precision medicine research accelerates in earnest.