Mid-America Regional Coordinating Center (MARCC)

中美洲区域协调中心 (MARCC)

• 批准号: 9762235
• 负责人: Jin-Moo Lee
• 金额: $ 29.03万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9762235
• 关键词: Acute; Adult; Agreement; Americas; Back; Caring; Cause of Death; Cities; Clinical; Clinical Research; Clinical Trials; Collaborations; Communication; Communities; Diagnostic; Emergency Medicine; Enrollment; Faculty; Fellowship; Future; Grant; Hospitals; Individual; Infrastructure; Institutional Review Boards; Intervention; K-Series Research Career Programs; Kansas; Leadership; Medical center; Mentors; Missouri; National Institute of Neurological Disorders and Stroke; Patient Recruitments; Patients; Phase; Public Health; Recovery; Research; Research Personnel; Resources; SECTM1 gene; Scientist; Specialist; Stroke; Stroke prevention; StrokeNet trials; Time; Training; Translational Research; Underrepresented Populations; United States; United States National Institutes of Health; Universities; University Hospitals; Washington; Work; aging population; career; data management; design; disability; experience; first responder; follower of religion Jewish; high risk; medical schools; patient population; post stroke; prevent; racial diversity; randomized trial; recruit; rural setting; skills; socioeconomics; stroke clinical trials; stroke incidence; stroke patient; stroke rehabilitation; stroke trials; tertiary care; urban setting

Stroke is a major public health problem in the United States, where it is the 5th leading cause of death and the leading cause of adult disability. Therefore, there is great need for translational and clinical research to develop interventions that prevent, treat, or enhance recovery after stroke. However, clinical trials require significant infrastructure, and the time and energy required to assemble this infrastructure for individual trials is a major barrier to progress. The NINDS StrokeNet was established in 2013 as a national stroke trials infrastructure, designed to maximize efficiencies by centralizing regulatory, IRB approval, and contractual agreements. With a single National Clinical Coordinating Center (NCC), a single National Data Management Center (DMC), and 25 Regional Coordinating Centers (RCCs) throughout the US, StrokeNet was established to efficiently recruit and enroll patients for stroke trials. The Midwestern states of Missouri (MO) and Kansas (KS) were not represented in the prior cycle of StrokeNet. Yet Missouri ranks 4th in stroke prevalence3 and 9th in stroke mortality4, among all states in the US, and Kansas is not far behind. Here we forward a proposal to develop the Mid-America Regional Coordinating Center (MARCC) at Washington University School of Medicine and affiliated Barnes-Jewish Hospital, in collaboration with three other high-volume tertiary care Stroke Centers spanning the midwestern states of MO, KS, and IL: St. Luke’s Hospital in Kansas City, MO; St. Louis University Hospital (SLU) in St. Louis, MO; and the Order of St. Francis Medical Center in Peoria, IL. Each of these medical centers is a tertiary care hub with large networks of referring hospitals, and have extensive experience participating in multi-center stroke trials. Thus, MARCC is a “Network of Networks.” Drawing from both rural and urban settings, the hospitals of MARCC admit almost 5,000 stroke patients per year, including patients from diverse racial backgrounds and socioeconomic strata. Moreover, the collective group of stroke clinicians, investigators, and scientists that will participate in MARCC have diverse expertise that will permit the implementation of stroke trials across the translational and treatment spectrum. We propose to establish MARCC as one of the 25 RCCs with the following specific aims: Aim 1. To establish and maintain a seamless tri-state stroke trials infrastructure—the Mid-America Regional Coordinating Center (MARCC). Aim 2. To effectively and efficiently conduct NINDS StrokeNet trials of stroke prevention, treatment and recovery through the MARCC. Aim 3. To recruit and train future clinician- scientists in stroke research through fellowship training and career enhancement.

中风是美国的主要公共卫生问题，它是第五大死亡原因， 成人残疾的主要原因。因此，非常需要翻译和临床研究来发展 预防，治疗或增强中风后恢复的干预措施。但是，临床试验需要重大 基础架构以及组装该基础设施所需的时间和精力是一个主要的试验 进步的障碍。 Ninds Strokenet成立于2013年，是一项国家中风试验基础设施， 旨在通过集中监管，IRB批准和合同协议来最大化效率。与 单个国家临床协调中心（NCC），单个国家数据管理中心（DMC）和25 整个美国的区域协调中心（RCC），建立了Strokenet，以有效招募和 注册患者进行中风试验。密苏里州中西部（MO）和堪萨斯州（KS）未代表 在Strotenet的先前周期中。然而，密苏里州在中风率中排名第四，中风死亡率第9位。 美国和堪萨斯州的国家不远。在这里，我们提出一项提议，以开发中美洲中部地区 华盛顿大学医学院和会员巴恩斯 - 犹太人协调中心（MARCC） 医院与其他三个大批量三级护理中心合作，中西部 MO，KS和IL州：密苏里州堪萨斯城的圣卢克医院；圣路易斯大学医院（SLU） 密苏里州路易斯；以及伊利诺伊州皮奥里亚的圣弗朗西斯医疗中心的命令。这些医疗中心中的每一个都是第三级 带有大型转诊医院网络的护理中心，并拥有丰富的参与多中心的经验 中风试验。那是MARCC是“网络网络”。医院从粗糙和城市环境中汲取 Marcc承认每年近5,000名中风患者，包括来自潜水员种族背景的患者 社会经济阶层。此外，集体中风临床医生，研究人员和科学家将 参加MARCC具有多种专业知识，可以允许在整个中实施中风试验 翻译和治疗范围。我们建议将MARCC确立为25个RCC之一 具体目的：目标1。建立和维持无缝的三州中风试验基础设施 - 中美洲 区域协调中心（MARCC）。目标2。有效，有效地进行NINDS Strokenet试验 通过MARCC预防中风，治疗和恢复。目标3。招募和培训未来的临床 - 通过奖学金培训和职业增强，中风研究中的科学家。