Mid-America Regional Coordinating Center (MARCC)

中美洲区域协调中心 (MARCC)

• 批准号: 10224350
• 负责人: Jin-Moo Lee
• 金额: $ 28.9万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10224350
• 关键词: Acute; Adult; Agreement; Americas; Back; Caring; Cause of Death; Cities; Clinical; Clinical Research; Clinical Trials; Collaborations; Communication; Communities; Diagnostic; Emergency Medicine; Enrollment; Faculty; Fellowship; Future; Grant; Hospitals; Individual; Infrastructure; Institutional Review Boards; Intervention; K-Series Research Career Programs; Kansas; Leadership; Medical center; Mentors; Missouri; National Institute of Neurological Disorders and Stroke; Patient Recruitments; Patients; Phase; Public Health; Recovery; Research; Research Personnel; Resources; SECTM1 gene; Scientist; Specialist; Stroke; Stroke prevention; StrokeNet trials; Time; Training; Translational Research; Underrepresented Populations; United States; United States National Institutes of Health; Universities; University Hospitals; Washington; Work; aging population; career; data management; design; disability; experience; first responder; follower of religion Jewish; high risk; medical schools; patient population; post stroke; prevent; racial diversity; randomized trial; recruit; rural setting; skills; socioeconomics; stroke clinical trials; stroke incidence; stroke patient; stroke rehabilitation; stroke trials; tertiary care; urban setting

Stroke is a major public health problem in the United States, where it is the 5th leading cause of death and the leading cause of adult disability. Therefore, there is great need for translational and clinical research to develop interventions that prevent, treat, or enhance recovery after stroke. However, clinical trials require significant infrastructure, and the time and energy required to assemble this infrastructure for individual trials is a major barrier to progress. The NINDS StrokeNet was established in 2013 as a national stroke trials infrastructure, designed to maximize efficiencies by centralizing regulatory, IRB approval, and contractual agreements. With a single National Clinical Coordinating Center (NCC), a single National Data Management Center (DMC), and 25 Regional Coordinating Centers (RCCs) throughout the US, StrokeNet was established to efficiently recruit and enroll patients for stroke trials. The Midwestern states of Missouri (MO) and Kansas (KS) were not represented in the prior cycle of StrokeNet. Yet Missouri ranks 4th in stroke prevalence3 and 9th in stroke mortality4, among all states in the US, and Kansas is not far behind. Here we forward a proposal to develop the Mid-America Regional Coordinating Center (MARCC) at Washington University School of Medicine and affiliated Barnes-Jewish Hospital, in collaboration with three other high-volume tertiary care Stroke Centers spanning the midwestern states of MO, KS, and IL: St. Luke’s Hospital in Kansas City, MO; St. Louis University Hospital (SLU) in St. Louis, MO; and the Order of St. Francis Medical Center in Peoria, IL. Each of these medical centers is a tertiary care hub with large networks of referring hospitals, and have extensive experience participating in multi-center stroke trials. Thus, MARCC is a “Network of Networks.” Drawing from both rural and urban settings, the hospitals of MARCC admit almost 5,000 stroke patients per year, including patients from diverse racial backgrounds and socioeconomic strata. Moreover, the collective group of stroke clinicians, investigators, and scientists that will participate in MARCC have diverse expertise that will permit the implementation of stroke trials across the translational and treatment spectrum. We propose to establish MARCC as one of the 25 RCCs with the following specific aims: Aim 1. To establish and maintain a seamless tri-state stroke trials infrastructure—the Mid-America Regional Coordinating Center (MARCC). Aim 2. To effectively and efficiently conduct NINDS StrokeNet trials of stroke prevention, treatment and recovery through the MARCC. Aim 3. To recruit and train future clinician- scientists in stroke research through fellowship training and career enhancement.

在美国，中风是一个主要的公共卫生问题，是第五大死亡原因