Molecular Regulation of Cell Development and Differentiation Phase III COBRE

细胞发育和分化的分子调控 III 期 COBRE

• 批准号: 9762125
• 负责人: DALE R ABRAHAMSON
• 金额: $ 112.79万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9762125
• 关键词: Adult; Applications Grants; Area; Award; Awareness; Bioinformatics; Cells; Centers of Research Excellence; Confocal Microscopy; Core Facility; Data; Development; Developmental Biology; Disease; Electron Microscopy; Embryonic Development; Ensure; Environment; Extramural Activities; Faculty; Fostering; Foundations; Funding; Future; Gene Transfer Techniques; Goals; Infrastructure; Interdisciplinary Study; Joints; Kansas; Laboratories; Maintenance; Medical center; Molecular; Molecular Profiling; Mus; Phase; Pilot Projects; Publications; Rattus; Regulation; Research; Research Personnel; Research Support; Resources; Seeds; Talents; Technology; Training; Transgenic Organisms; Universities; high resolution imaging; improved; insight; multidisciplinary; next generation sequencing; novel therapeutics; operation; programs

OVERALL PROJECT SUMMARY ABSTRACT Funds are requested to renew a Center of Biomedical Research Excellence (COBRE) at the University of Kansas Medical Center (KUMC) as a Phase III, five year award. This COBRE has a research focus on the regulation of cell development and differentiation, which may provide new, therapeutic insights into a host of developmental abnormalities and diseases. During the initial 10 year term, we will have trained 15 Beginning Investigators and most of them are becoming successful, independent researchers. An important feature of this application is the maintenance of 3 scientific Cores that provide research support to all of the Center faculty as well as to KUMC as a whole. Together with Administrative Core A, there are Cores supporting transgenesis in mice and rats (Core B), molecular profiling (next generation sequencing, microarray, and bioinformatics, Core C), and high resolution imaging (confocal and electron microscopy, Core D). The second major component of this application is the operation of a Pilot Projects Program in developmental biology, which represents a natural extension of a pilot program initiated in Phase I and II that has a proven, successful track record. The outstanding combination of scientific talent, strong research environment, and substantial institutional commitment to the scientific Cores and Pilot Projects Program ensure that this COBRE will continue to foster the development of a thematic, multidisciplinary research effort and enhance the ability of KUMC researchers to compete for extramural support.

项目总体概要 抽象的 需要资金来更新生物医学卓越研究中心（COBRE） 堪萨斯大学医学中心 (KUMC) 作为第三阶段、为期五年的奖项。这个COBRE 研究重点是细胞发育和分化的调控，这可能 为许多发育异常和疾病提供新的治疗见解。 在最初的 10 年任期内，我们将培训 15 名初级研究员，其中大部分 他们正在成为成功的独立研究人员。这个的一个重要特点 应用程序是维护 3 个科学核心，为所有领域提供研究支持 中心教员以及整个 KUMC。与行政核心 A 一起， 有支持小鼠和大鼠转基因的核心（核心 B）、分子分析（下一个） 世代测序、微阵列和生物信息学，核心 C) 和高分辨率 成像（共焦和电子显微镜，Core D）。这个的第二个主要组成部分 应用程序是发育生物学试点项目计划的运作， 代表了第一阶段和第二阶段启动的试点计划的自然延伸，该计划具有 经过验证的成功记录。优秀的科技人才组合，实力雄厚 研究环境，以及对科学核心和重大机构的承诺 试点项目计划确保 COBRE 将继续促进 主题、多学科研究工作，并增强 KUMC 研究人员的能力 竞争外部支持。