Molecular Regulation of Cell Development and Differentiation

描述（由申请人提供）：资金被要求更新生物医学研究卓越中心（COBRE）在堪萨斯医学中心（KUMC）的一个额外的五年期。该COBRE的研究重点是细胞发育和分化的调控。在最初的5年任期内，6名初级研究员从COBRE毕业，他们都成为了成功的独立研究人员。五名新的初级研究员加入了中心，我们的目标是帮助他们成为独立资助的研究员。一个PI，两个co-PI，一个内部咨询委员会（IAC），一个强大的指导教师小组，以及一个由杰出调查人员组成的外部咨询委员会（EAC）已经组装起来，以实现这一目标。该中心还旨在改善KUMC的研究基础设施。预期的结果将是更多的研究生产力，反映在联合出版物和赠款支持的基础上发展生物学的主题。一名导师已被分配到每个新的开始调查教师招聘，并制定了个人辅导计划和生产力时间表。指导计划的主要特点包括导师对研究项目进行持续的批判性评估，半年一次的会议和科学写作的特殊培训。我们希望，我们目前的每一个初级教师将成功地竞争从美国国立卫生研究院或其他国家授权机构的R 01级的支持在3年内加入COBRE。一旦获得资助，他们将循环关闭赠款为新的教师腾出空间，我们有坚定的承诺，从系主任/中心主任谁将提供这些招聘。另一个重要的特点是维护3个科学核心，为中心的所有教师提供研究支持。除了管理和指导核心A之外，还有支持转基因的核心（核心B）、分子谱分析（核心C）和高分辨率成像（核心D）。杰出的科学人才，研究环境和大量的机构承诺的杰出组合，确保这个COBRE将继续促进主题，多学科研究工作的发展，并提高新的研究人员竞争NIH支持的能力。

DESCRIPTION (provided by applicant): Funds are requested to renew a Center of Biomedical Research Excellence (COBRE) at the University of Kansas Medical Center (KUMC) for an additional five year period. This COBRE has a research focus on the regulation of cell development and differentiation. During the initial, 5 year term, 6 Beginning Investigators graduated from the COBRE, and all are becoming successful, independent researchers. Five new Beginning Investigators have joined the Center and our goal is to help them become independently funded investigators as well. A PI, two co-PIs, an Internal Advisory Committee (lAC), a robust group of mentoring faculty, and an External Advisory Committee (EAC) of distinguished investigators have been assembled to achieve this goal. The Center is also designed to improve the research infrastructure at KUMC. The expected outcome will be more research productivity as reflected in joint publications and grant support based on a developmental biology theme. A Mentor has been assigned to each of the new Beginning Investigator faculty recruits, and individual mentoring plans and productivity timetables have been developed. Central features of the mentoring plans include ongoing critical evaluation of research projects by Mentors, semiannual conferences, and special training on scientific writing. We expect that each of our current junior faculty members will compete successfully for R01-level support from the NIH or other national granting agency within 3 years of joining the COBRE. Once funded, they will cycle off the grant making room for new faculty, and we have firm commitments from Department Chairs/Center Directors who will provide these recruits. Another important feature is the maintenance of 3 scientific Cores to provide research support to all of the Center's faculty. Together with an Administrative and Mentoring Core A, there are Cores supporting transgenesis (Core B), molecular profiling (Core C), and high resolution imaging (Core D). The outstanding combination of exceptional scientific talent, research environment, and substantial institutional commitment, ensure that this COBRE will continue to foster the development of a thematic, multidisciplinary research effort and enhance the ability of new investigators to compete for NIH support.