Molecular Regulation of Cell Development and Differentiation

描述（由申请人提供）：五年的资金被要求在ULKMC（KUMC）建立一个生物医学研究卓越中心，重点是细胞发育和分化的分子调控。五个有才华的新教师谁分享这一研究兴趣被选中，帮助他们成为资助的独立调查员的目标。一个PI，两个co-PI，一个内部咨询委员会（IAC），一组指导教师和一个由杰出研究人员组成的外部咨询委员会（EAC）已经组装起来，以实现这一目标。该中心还旨在改善KUMC的基础设施和研究环境。该计划的预期成果将是更多的研究生产力，反映在联合出版物，资助R 01赠款，以及基于发育生物学主题的计划项目和研究中心赠款。已经为每个初级教员分配了一名导师，并制定了个人辅导计划和时间表。指导计划的主要特点包括导师和IAC对研究项目进行持续的批判性评估，与EAC成员举行半年一次的会议，以及在研讨会上进行统计、手稿和赠款写作方面的特别培训。初始组将获得长达3年的支持。在这一时间框架内，每个成员将有望成功竞争NIH R 01型研究支持。一旦外部资助，他们将在财政上轮换赠款，为新的初级教师的增加腾出空间，我们有部门主席/中心主任谁将提供这些新的教师坚定的承诺。5年内，该基金将资助10-15名独立研究人员。另一个重要特点是建立3个新的科学核心能力，为中心的教师提供额外的研究支持。与管理核心A一起，将有支持转基因、基因靶向和基因分型（核心B）、分子分析和重组的核心。

DESCRIPTION (provided by applicant): Five years of funding are requested to develop a Center of Biomedical Research Excellence at the ULKMC (KUMC) with a focus on the molecular regulation of cell development and differentiation. Five talented new faculty who share this research interest were selected with the goal of helping them become funded independent investigators. A PI, two co-PIs, an internal advisory committee (IAC), a group of mentoring faculty, and an external advisory committee (EAC) of distinguished investigators have been assembled to achieve this goal. The Center is also designed to improve the infrastructure and research environment at KUMC. The expected outcome of the program will be more research productivity as reflected in joint publications, funded R01 grants, and program project and research center grants based on a developmental biology theme. A mentor has been assigned to each initial junior faculty member, and individual mentoring plans and timetables have been developed. Central features of the mentoring plans include ongoing critical evaluation of the research projects by mentors and IAC, semiannual conferences with EAC members, and special training on statistics, manuscript and grant writing in workshops. The initial group will receive support for up to 3 years. Within this time frame, each member will be expected to compete successfully for NIH R01-type research support. Once funded externally, they will rotate off the grant financially to make room for the addition of new junior faculty, and we have firm commitments from Department Chairs/Center Directors who will provide these new faculty. Over 5 years, the grant will support 10-15 independent researchers. Another important feature is to establish 3 new scientific Core capabilities to provide additional research support for the Center's faculty. Together with the Administrative Core A, there will be Cores supporting transgenesis, gene targeting and genotyping (Core B), molecular profiling and recombin