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Novel Antimicrobials for Eye Infections

用于眼部感染的新型抗菌药物

基本信息

批准号：
9764367
负责人：
VALENTIN V RYBENKOV
金额：
$ 21.52万
依托单位：
UNIVERSITY OF OKLAHOMA
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-01 至 2020-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9764367
关键词：
Anti-Bacterial Agents Antibiotic Therapy Antibiotics Bacteria Bacterial Eye Infections Biological Assay Blindness Chromatin Chromosome Structures Collaborations Complication Contact Lenses Corneal Ulcer Data Development Disinfection Drug Targeting Endophthalmitis Enterobacteriaceae Escherichia coli Eye Eye Infections Family Fluoroquinolones Goals Gram-Negative Bacteria Growth Human Impairment Keratitis Lead Microbial Biofilms Microbiology Morphology Multi-Drug Resistance Operative Surgical Procedures Ophthalmologic Surgical Procedures Organism Pharmaceutical Preparations Phenotype Physicians Play Predisposition Pseudomonas aeruginosa Pseudomonas aeruginosa infection Research Resistance Role Staphylococcus aureus Testing Virulence antimicrobial condensin drug discovery epigenetic regulation experimental study fitness follow-up genetic information high throughput screening inhibitor/antagonist mouse model mutant novel novel strategies pathogen pathogenic bacteria segregation small molecule tool

项目摘要

Novel Antimicrobials for Eye Infections ABSTRACT Bacterial eye infections frequently arise as a complication of corrective surgery or contact lens use. A growing number of such incidents fail to respond to available antibiotics resulting in irreversible eye damage and vision loss. Identification of new antibacterial compounds is urgently needed. This project pursues the development of antimicrobials against a novel target, bacterial condensins. Condensins play a central role in global chromosome organization and contribute to faithful segregation of genetic information in diverse organisms. In Pseudomonas aeruginosa, condensins regulate switching between planktonic and sessile phenotypes and are required for virulence during eye infection. This project seeks to validate condensins as a plausible drug target and develop small molecule condensin inhibitors. The primary focus will be on P. aeruginosa. However, the inhibitors display activity against other pathogens as well.

用于眼部感染的新型抗菌药物抽象的细菌性眼部感染经常作为矫正手术或使用隐形眼镜的并发症而出现。一个不断成长的许多此类事件对可用的抗生素没有反应，导致不可逆转的眼睛和视力损伤损失。迫切需要鉴定新的抗菌化合物。该项目致力于发展针对新靶点细菌凝集素的抗菌药物。凝缩素在全球范围内发挥着核心作用染色体组织并有助于不同生物体中遗传信息的忠实分离。在铜绿假单胞菌，凝缩蛋白调节浮游和固着表型之间的转换，并且是眼部感染期间需要毒力。该项目旨在验证凝缩蛋白作为合理的药物靶点并开发小分子凝缩蛋白抑制剂。主要关注点是铜绿假单胞菌。然而，抑制剂也表现出针对其他病原体的活性。