Penn Resource-based Center to Support and Translate Skin DiseasesResearch

宾夕法尼亚大学资源中心支持和转化皮肤病研究

• 批准号: 9765154
• 负责人: GEORGE COTSARELIS
• 金额: $ 76.05万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-15 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9765154
• 关键词: Advisory Committees; Applications Grants; Basic Science; Bioinformatics; Biology; Biometry; Budgets; Cells; Clinical; Collaborations; Communication; Community Outreach; Cutaneous; Data; Data Analyses; Dermatology; Development; Disease; Engineering; Ensure; Faculty; Feasibility Studies; Feedback; Fostering; Foundations; Funding; Generations; Genetically Engineered Mouse; Goals; Grant; High School Student; Histology; Human; Human Resources; Immunology; In Vitro; Individual; Investigation; Mentors; Minority; Molecular; Mus; Names; Natural regeneration; Newsletter; Occupational activity of managing finances; Patients; Philadelphia; Pilot Projects; Productivity; Reagent; Research; Research Design; Research Personnel; Resources; Sampling; Schools; Scientist; Services; Skin; Speed; Structure; Students; Surveys; Techniques; Tissues; Translating; Translational Research; Translations; Woman; base; clinical practice; design; genome-wide analysis; human disease; in vivo; innovation; interest; investigator training; meetings; member; mouse model; new technology; news; outreach; outreach program; peer coaching; population based; pre-clinical; preclinical study; programs; public health relevance; research study; satisfaction; school district; skin disorder; success; tool; translational approach; web site

 DESCRIPTION (provided by applicant): Rapid translation of basic information in cutaneous biology to preclinical studies and clinical practice is becoming a realistic prospect due to the ever-increasing sophistication of basic research on development, regeneration, immunology, and diseases of the skin, together with powerful new technologies for gathering and analyzing genome-wide and population-based data. The overall goals of the proposed Penn SBDRC are to leverage our strengths in basic and translational science and dermatoepidemiology to support outstanding basic research in cutaneous biology and diseases and to promote the critical transition from bench research to bedside practice. To achieve these goals we will establish Resource and Administrative Cores. The Resource Cores are designed to enable and enhance the speed and efficiency of skin research; provide unique expertise and access to cutaneous tissues and specialized reagents; provide guidance on appropriate study design; provide easy access to biostatistical and bioinformatics support personnel; and continuously innovate to maintain our research at the forefront of the field. They are: Core A - Skin Histology and Characterization; Core B - Skin Procurement and Engineering; and Core C - Study Design and Data Analysis. The aims of the Administrative Core are to: provide structure and oversight for the SBDRC; ensure the diversity and success of researchers in cutaneous biology and diseases; attract new investigators to cutaneous research; and foster exchange of ideas, collaboration, and interdisciplinary and basic-translational projects. To achieve these Aims, the Administrative Core will: (i) establish an Executive Committee to provide financial management and oversight; (ii) organize an Advisory Committee of internal and external experts to provide feedback and suggest improvements, and a Diversity Advisory Committee to advise the Executive Committee on strategies to ensure diversity through best hiring and retention practices; (iii) provide administrative support to the SBDRC and Core Directors; (iv) organize specific mentoring programs for junior faculty, senior trainees, women and diversity faculty and trainees, and Core Directors; (v) organize monthly Peer Mentoring research presentations/grant application discussions; (vi) establish a Community Outreach Program to attract students from the predominantly minority Philadelphia school district to the excitement and promise of cutaneous research; (vii) provide Pilot & Feasibility Studies funding to support young investigators, interdisciplinary and/or basic-translational collaborations, and investigators from outside Dermatology interested in skin-oriented research; (viii) sponsor Seminars related to cutaneous biology and disease; (ix) hold an Annual Research Retreat; (x) organize Communications functions including a quarterly newsletter and an SBDRC website to advertise SBDRC seminars and meetings, Core services, and membership information.

 描述(由申请人提供)：由于皮肤发育、再生、免疫学和皮肤疾病的基础研究日益复杂，以及收集和分析全基因组和基于人群的数据的强大新技术，快速将皮肤生物学的基本信息转换为临床前研究和临床实践正成为一种现实的前景。拟议中的宾夕法尼亚州立大学SBDRC的总体目标是利用我们在基础科学和转化科学以及皮肤流行病学方面的优势，支持皮肤生物学和疾病方面的杰出基础研究，并促进从临床研究到临床实践的关键过渡。为了实现这些目标，我们将建立资源和管理核心。资源核心旨在支持和提高皮肤研究的速度和效率；提供独特的专业知识和获得皮肤组织和专门试剂的途径；就适当的研究设计提供指导；提供与生物统计和生物信息学支持人员的便捷联系；并不断创新，使我们的研究保持在该领域的前沿。它们是：核心A-皮肤组织学和特征；核心B-皮肤采购和工程；以及核心C-研究设计和数据分析。管理核心的目标是：为SBDRC提供结构和监督；确保皮肤生物学和疾病研究人员的多样性和成功；吸引新的研究人员从事皮肤研究；促进思想交流、合作以及跨学科和基础-翻译项目。为实现这些目标，行政核心将：(1)建立一个执行委员会，以提供财务管理和监督；(2)组织一个由内部和外部专家组成的咨询委员会，以提供反馈并提出改进建议；以及一个多样性咨询委员会，就通过最佳招聘和保留做法确保多样性的战略向执行委员会提供咨询意见；(3)向SBDRC和核心主任提供行政支助；(4)为初级教员、高级实习生、妇女和多样性教员和受训人员以及核心主任组织具体的指导方案；(5)每月组织同行指导研究报告/赠款申请讨论；(Vi)建立一个社区外展计划，以吸引来自少数族裔为主的费城学区的学生对皮肤研究感到兴奋和充满希望；(Vii)提供试点和可行性研究资金，以支持对皮肤研究感兴趣的年轻研究人员、跨学科和/或基础-翻译合作，以及来自皮肤科以外的研究人员；(Viii)赞助与皮肤生物学和疾病有关的研讨会；(Ix)举办年度研究务虚会；(X)组织宣传活动，包括季度通讯和SBDRC网站，以宣传SBDRC研讨会和会议、核心服务和成员信息。