Columbia University Skin Disease Resource-Based Center (epiCURE)

 描述(由申请人提供)：本申请建议在哥伦比亚大学(Epicure)建立一个以皮肤病资源为基础的核心中心。Epicure旨在解决医学研究所定义的转化研究连续体上的关键障碍。这一连续体定义了生物医学研究的三个关键转换阶段：基础科学转化为临床前疗效，转化为临床有效性。Epicure中心的核心进行了战略性配置，以应对皮肤病研究中的这些关键阶段，并提供一套独特的服务和资源，以促进研究社区沿着由基于精密医学的算法驱动并响应NIAMS使命的翻译连续体管道前进。Epicure中心和随之而来的机构承诺可以通过为研究人员互动提供独特有效的基于服务的工具来实现这一目标，从而进一步促进皮肤生物学和皮肤病方面的教育、培训和研究。Epicure的配置代表了一种自然、合乎逻辑的发展，建立在我们现有的SDRC在过去18年中在基础发现和翻译研究方面的成功基础上，并催化它们进入临床。我们对选择Epicure的服务和资源部分进行了非常仔细的考虑，以便它们支持哥伦比亚大学和更广泛的研究社区的现有研究成果，研究社区由哥伦比亚大学的37名研究人员以及纽约大都市区和全国其他18个机构的37名研究人员组成。除了管理核心和创新丰富计划外，Epicure还围绕三个服务核心构建，这三个服务核心涵盖基础、临床前和翻译研究：1)皮肤干细胞成像和操作(SCIM)；2)皮肤免疫、完整性和疾病模型(SIND)；以及3)转化和精确医学资源(TRAP)。Epicure中心的总体目标是打破翻译研究的障碍，加快皮肤病研究的调查进度，迅速从基础推进到床边。

 DESCRIPTION (provided by applicant): This application proposes the creation of a Skin Disease Resource-Based Core center at Columbia University (epiCURE). The epiCURE is designed to address critical roadblocks on the Continuum of Translational research as defined by the Institute of Medicine. The continuum defines three critical translational phases in biomedical research: basic science into pre-clinical efficacy into clinical effectiveness. The Cores of the epiCURE center have been strategically configured to address these critical phases in skin disease research, and provide a unique set of services and resources to facilitate advancement of the Research Community along the translational continuum pipeline that is driven by a Precision Medicine-based algorithm and is responsive to the NIAMS mission. The epiCURE Center, and the Institutional Commitment that accompanies it, can accomplish this goal by providing a uniquely effective service-based vehicle for investigator interactions that further education, training and research in cutaneous biology and skin disease. The configuration of the epiCURE represents a natural, logical progression built on the previous successes of our existing SDRC over the past 18 years, in bridging basic discoveries and translational research, and catalyzing their entry into the clinic. We have given very careful consideration to selecting the service and resource components of the epiCURE so that they bolster the existing research excellence at Columbia University and the broader Research Community, which is comprised of 37 investigators at Columbia University as well as 37 investigators at other 18 institutions in the New York metropolitan area and across the country. In addition to an Administrative Core and innovative Enrichment Program, the epiCURE is structured around three Service Cores that span a continuum of basic, pre-clinical and translational research: 1) Skin Stem Cell Imaging and Manipulation (SCIM); 2) Skin Immunity, Integrity and Disease Models (SIND); and 3) Translational and Precision Medicine Resources (TRAP). The overall goal of the epiCURE center is to break down barriers to translational research, and accelerate the progress of investigation in skin disease research to rapidly advance from basepairs to bedside.