Columbia University Skin Disease Resource-Based Center (epiCURE)

 描述（由申请人提供）：本申请建议在哥伦比亚大学（epiCURE）建立一个基于资源的皮肤病核心中心。epiCURE旨在解决医学研究所定义的转化研究连续体的关键障碍。该连续体定义了生物医学研究的三个关键转化阶段：基础科学到临床前有效性到临床有效性。epiCURE中心的核心已被战略性地配置，以解决皮肤病研究中的这些关键阶段，并提供一套独特的服务和资源，以促进研究社区沿着由基于精准医学的算法驱动的连续转化管道的发展，并响应NIAMS的使命。epiCURE中心及其附属机构承诺可以通过为研究者互动提供独特有效的基于服务的工具来实现这一目标，这些工具可以促进皮肤生物学和皮肤疾病的教育、培训和研究。epiCURE的配置代表了一种自然的、合乎逻辑的进展，它建立在我们现有SDRC过去18年来在基础发现和转化研究之间的桥梁上，并促进它们进入临床。我们已经非常仔细地考虑了选择epiCURE的服务和资源组件，以便它们支持哥伦比亚大学和更广泛的研究社区的现有研究卓越，该社区由哥伦比亚大学的37名研究人员以及纽约大都市区和全国其他18个机构的37名研究人员组成。除了管理核心和创新的丰富计划外，epiCURE还围绕三个服务核心构建，涵盖基础，临床前和转化研究的连续性：1）皮肤干细胞成像和操作（SCIM）; 2）皮肤免疫，完整性和疾病模型（SIND）; 3）转化和精准医学资源（TRAP）。epiCURE中心的总体目标是打破转化研究的障碍，加速皮肤病研究的进展，使其迅速从碱基对发展到临床。

 DESCRIPTION (provided by applicant): This application proposes the creation of a Skin Disease Resource-Based Core center at Columbia University (epiCURE). The epiCURE is designed to address critical roadblocks on the Continuum of Translational research as defined by the Institute of Medicine. The continuum defines three critical translational phases in biomedical research: basic science into pre-clinical efficacy into clinical effectiveness. The Cores of the epiCURE center have been strategically configured to address these critical phases in skin disease research, and provide a unique set of services and resources to facilitate advancement of the Research Community along the translational continuum pipeline that is driven by a Precision Medicine-based algorithm and is responsive to the NIAMS mission. The epiCURE Center, and the Institutional Commitment that accompanies it, can accomplish this goal by providing a uniquely effective service-based vehicle for investigator interactions that further education, training and research in cutaneous biology and skin disease. The configuration of the epiCURE represents a natural, logical progression built on the previous successes of our existing SDRC over the past 18 years, in bridging basic discoveries and translational research, and catalyzing their entry into the clinic. We have given very careful consideration to selecting the service and resource components of the epiCURE so that they bolster the existing research excellence at Columbia University and the broader Research Community, which is comprised of 37 investigators at Columbia University as well as 37 investigators at other 18 institutions in the New York metropolitan area and across the country. In addition to an Administrative Core and innovative Enrichment Program, the epiCURE is structured around three Service Cores that span a continuum of basic, pre-clinical and translational research: 1) Skin Stem Cell Imaging and Manipulation (SCIM); 2) Skin Immunity, Integrity and Disease Models (SIND); and 3) Translational and Precision Medicine Resources (TRAP). The overall goal of the epiCURE center is to break down barriers to translational research, and accelerate the progress of investigation in skin disease research to rapidly advance from basepairs to bedside.