Environmental heavy metals and risk of ischemic heart disease and stroke in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
巴西成人健康纵向研究 (ELSA-Brasil) 中的环境重金属与缺血性心脏病和中风的风险
基本信息
- 批准号:9890186
- 负责人:
- 金额:$ 17.37万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-05-21 至 2024-03-31
- 项目状态:已结题
- 来源:
- 关键词:AdultAffectArsenicBiological ProcessBiologyBiomedical ResearchBloodBlood PreservationBrazilCadmiumCardiovascular DiseasesCardiovascular systemCase-Control StudiesCessation of lifeChinaChromiumClinicalCobaltCollectionConsensusCopperCross-Sectional StudiesDataDeveloping CountriesDevelopmentDiabetes MellitusDietDietary InterventionDiseaseDisease OutcomeEnvironmental ExposureEpidemicEtiologyEuropeEventExposure toFunding OpportunitiesHealthHeavy MetalsHypertensionIndividualInternationalInterviewInvestmentsJointsLaboratoriesLeadLinkLongitudinal StudiesMagnesiumManganeseMediatingMercuryMetabolismMetal exposureMetalsMolybdenumMyocardial IschemiaNational Toxicology ProgramNested Case-Control StudyNickelObesityOutcomeParticipantPersonsPhysical ExaminationPlayPopulationPortuguesePositioning AttributeProspective StudiesProspective cohortProspective cohort studyPublic HealthReportingResearchResearch PersonnelResourcesRiskRisk FactorsRoleSamplingSeleniumSerumSiteSmokingSouth AmericaStrokeSupplementationTestingTimeToxic effectTrace ElementsTrace metalTungstenUnited StatesUrineVanadiumVascular DiseasesVascular SystemWomanWorkZincadjudicatecardiometabolismcardiovascular disorder preventioncardiovascular disorder riskcase controlcohortcoronary artery calciumcoronary calcium scoringcost efficientdata resourcedesigndiabetes riskdietary trace elementdisabilityexperiencefollow-upglobal healthinterestmennervous system disorderphysical inactivitypopulation basedpopulation healthprogramstoxic metal
项目摘要
PROJECT SUMMARY
Environmental degradation and exposure to heavy metals (over which individuals often have little control) may
have a direct impact on cardiovascular diseases (CVD) development, which have become one of the most
pressing nemesis for individual- and population-health globally. Recent studies have provided provocative
evidence linking environmental exposure to heavy metals to increased risk of diabetes and hypertension, which
are strong CVD risk factors. In contrast, prospective cohort studies have shown that higher levels of dietary and
serum essential trace metals are directly associated with lower CVD risk and that supplementation of which may
have potential benefits by mitigating the effects of toxic metals on the cardiovascular system. However, very few
studies have directly and comprehensively investigated exposure to multiple metals particularly their joint effects
on affecting CVD risk (including stroke). The ongoing Brazilian Longitudinal Study of Adult Health (in Portuguese,
‘Estudo Longitudinal de Sau´ de do Adulto’, ELSA-Brasil), the only large prospective study established in South
America to specifically investigate risk factors for cardiometabolic health, represents a unique resource to study
the roles of multiple metal exposures and their interactions with dietary trace elements in affecting CVD risk. At
baseline, 4,428 CVD-free participants at the ELSA-Brasil site in Sao Paulo completed 1) physical examinations;
2) clinical laboratory tests; 3) in-person interviews; 4) collections of blood and urine samples; and 5) a CT
examination to quantify coronary artery calcium (CAC) score. To date, a total of 466 incident CVD (~150 stroke)
cases have been adjudicated in the ELSA-Brasil cohort in the 10-year follow up. ln the current application aims
to investigate, we will leverage these exceptional resources and the substantial investment of time and effort by
ELSA-Brasil study investigators over the past ten years to investigate, in a most cost-efficient and timely manner,
the roles of metals playing in CVD development. Specifically, the current application aims to utilize this ongoing
prospective cohort study to not only determine whether heavy metal exposures increase CAC score and CVD
risk, but also identify the optimal body levels of essential metals that could mitigate CVD risk from toxic metals.
If antagonistic effects exist and optimal body levels of essential metals that could reduce toxic metal impacts are
confirmed, this work would lead to simple, safe, readily-available, acceptable and highly-affordable nutritional
intervention for CVD prevention that will have both clinical and public health significance worldwide.
项目总结
项目成果
期刊论文数量(0)
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PAULO ANDRADE LOTUFO其他文献
PAULO ANDRADE LOTUFO的其他文献
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{{ truncateString('PAULO ANDRADE LOTUFO', 18)}}的其他基金
Environmental heavy metals and risk of ischemic heart disease and stroke in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
巴西成人健康纵向研究 (ELSA-Brasil) 中的环境重金属与缺血性心脏病和中风的风险
- 批准号:
10600062 - 财政年份:2020
- 资助金额:
$ 17.37万 - 项目类别:
Environmental heavy metals and risk of ischemic heart disease and stroke in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
巴西成人健康纵向研究 (ELSA-Brasil) 中的环境重金属与缺血性心脏病和中风的风险
- 批准号:
10380884 - 财政年份:2020
- 资助金额:
$ 17.37万 - 项目类别:
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