Resting State Connectivity in White Matter

白质的静息态连接

• 批准号: 9891105
• 负责人: John C Gore
• 金额: $ 49.94万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-30 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9891105
• 关键词: 3-Dimensional; Anesthesia procedures; Anisotropy; Appearance; Architecture; Area; Atlases; Biophysical Process; Biophysics; Blood Volume; Brain; Brain Mapping; Brain region; Complex; Contrast Media; Data; Derivation procedure; Descriptor; Diffusion; Diffusion Magnetic Resonance Imaging; Disease; Electrophysiology (science); Evaluation; Exhibits; Goals; Human; Image; MION; Magnetic Resonance Imaging; Mathematics; Measurement; Measures; Methods; Microelectrodes; Monkeys; Nature; Pathway interactions; Population; Primates; Reproducibility; Research; Resolution; Rest; Scanning; Signal Transduction; Stimulus; Structure; Variant; Visual system structure; anatomic imaging; base; blood oxygen level dependent; field study; hemodynamics; neural network; neural stimulation; nonhuman primate; novel; novel strategies; public health relevance; relating to nervous system; response; tractography; white matter

 DESCRIPTION (provided by applicant): The goals of this proposal are to further investigate and evaluate recent new discoveries about the nature of temporal variations in magnetic resonance imaging (MRI) signals from the human brain, acquired in a resting state, which potentially provide a completely new basis for quantifying the functional architecture of white matter. We have recently shown that local inter-voxel correlations between resting state signal fluctuations within white matter are spatially anisotropic. Measurements of these anisotropic correlations and subsequent analyses permit the derivation of a new mathematical descriptor, a functional connectivity tensor (FCT) that quantifies the functional synchronization between neighboring voxels and delineates longer range dynamic connections. Some of the features of FCTs superficially closely resemble the appearance of diffusion tensor imaging (DTI) data across large brain regions but without the use of any diffusion gradients and based on completely different biophysical phenomena. This discovery demonstrates that white matter tracts exhibit functional, temporal variations which in turn suggest a new approach for integrating functional and structural information. The construction and analysis of FCTs permits tractography of functional pathways that often appear to follow white matter tracts, potentially revealing directions of flow of neural information. Furthermore, the functional tensors appear to change in response to neural stimulation, even though task-activation of white matter has proven elusive. Resting state connectivity has been extensively used to delineate functional circuits within the cortex but to date has been completely overlooked in white matter, and current opinions are biased against being able to detect neural activity in white matter using MRI. The objectives of this research therefore are to construct functional connectivity tensors in normal brains at rest, compare these to underlying structural features, and elucidate the underlying biophysical mechanisms that account for their origins. Our specific aims are (i) to measure and characterize functional connectivity tensors in a resting state in normal subjects, assess their reproducibility, and determine how they depend on specific technical aspects of acquisition and post- processing; we will quantitatively assess whether FCT data conform to white matter tracts, which may be achieved by analyses of FCT and DTI atlases created from a population of normal subjects co-registered to the same space; (ii) to investigate the biophysical origins of resting state correlational anisotropy in humans, and how they vary with stimulation; and (iii) to validate the basis and interpretation of these correlations by high field studies of nn-human primates, in which we will determine whether the correlations originate from hemodynamic changes and how they relate to underlying neural electrical activity. Overall, these will be the first comprehensive evaluations of our novel observations of anisotropy of correlations in resting state MRI signals from white matter. The proposed use of FCTs for mapping of brain functional connectivity is compelling and offers to advance our understanding of the functional organization of complex neural networks in the brain.