Replacement and Upgrade of a 3T MR Scanner for Research

用于研究的 3T MR 扫描仪的更换和升级

• 批准号: 9075982
• 负责人: John C Gore
• 金额: $ 199.78万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-15 至 2019-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9075982
• 关键词: Abdomen; Aging; Architecture; Biochemistry; Biological Process; Brain; Breast; Categories; Clinical Management; Data; Development; Diagnosis; Functional Magnetic Resonance Imaging; Funding; Healthcare; Housing; Image; Institutes; Magnetic Resonance Imaging; Malignant Neoplasms; Manufacturer Name; Metabolic Diseases; Methods; Morphology; Neurosciences; Noise; Patients; Physics; Physiology; Population; RF coil; Research; Research Personnel; Research Project Grants; Resources; Science; Scientist; Signal Transduction; Spectrum Analysis; Support System; System; Time; Tissues; United States National Institutes of Health; Universities; Vertebral column; digital; experience; falls; human subject; imaging biomarker; imaging modality; improved; in vivo; instrument; meetings; neuropsychiatry; non-invasive imaging; soft tissue; spectroscopic imaging

 DESCRIPTION (provided by applicant): This is an application for funding to replace and upgrade a 3 Tesla magnetic resonance imaging (MRI) and spectroscopy (MRS) system for human subjects that has been in use for research full-time for over a decade at Vanderbilt University. The current scanner is heavily used by over 60 active investigators with NIH funding who rely on high quality MRI and MRS data for diverse research applications. We aim to install a 3Tesla 70-cm bore Ingenia scanner manufactured by Philips Healthcare to replace the existing scanner, which is an aging system no longer fully supported by the manufacturer. MRI is well established as the single most powerful non-invasive imaging modality for studies of soft-tissues. MRI and MRS can be used to provide uniquely valuable information about tissue composition, morphology and function, as well as quantitative descriptions of many underlying biological processes. Our current system unfortunately precludes the exploration of several new avenues of MR research and some new applications are beyond the capabilities of our current machine. The new system will provide three major specific advantages. [1] it will be able to implement new methods such as multi-band acquisitions that cannot be implemented on the current platform, and investigators can be assured of continuing support for several years; [2] it has a larger bore, so we can image larger patients that currently are excluded from studies, and achieve higher RF and main field uniformity. The larger bore is essential to meet the challenges of our local population and to permit more and better studies of the abdomen, spine and breast; [3] the new all-digital architecture with direct conversion of MR signals within the RF coils produces images with higher (40%) signal to noise ratio. In this application we feature 29 selected investigators all of whom are experienced users of the current 3T scanner, in a variety of research applications. Their research projects fall into 4 main categories: (1) Imaging physics, the development of new and improved MR imaging methods: (2) Cancer, and applications of MRI and MRS for diagnosis and clinical management, including the development of imaging biomarkers to assess treatments: (3) Neuroscience, and the application of structural and functional MRI to studies of the architecture and functional organization of the brain, in normal as well as neuropsychiatric conditions: (4) Metabolic Disorders, and the development and applications of advanced MR methods to studies of physiology and biochemistry in vivo. The projects of the Users described herein would require approximately 80% of the useable time available on the scanner, and the remainder would be used for exploratory research and new directions. The scanner will be housed and managed within the Vanderbilt University Institute of Imaging Science, and will remain a primary research resource for a large group of imaging scientists. The instrument will be supported by an established group of MR imaging experts and support staff. A comprehensive plan has been developed for the financial and technical support of the system as well as for its management, and the system is assured of strong institutional support and oversight.

 描述(申请人提供)：这是一份资金申请，用于更换和升级范德比尔特大学全职使用了十多年的人类受试者3Tesla磁共振成像(MRI)和波谱(MRS)系统。目前的扫描仪被60多名活跃的研究人员大量使用，他们得到了NIH的资助，他们依靠高质量的MRI和MRS数据进行各种研究应用。我们的目标是安装飞利浦医疗制造的3Tesla 70厘米口径雌驼龙扫描仪，以取代现有的扫描仪，现有扫描仪是一个老化的系统，不再得到制造商的完全支持。磁共振成像被公认为软组织研究中最强大的非侵入性成像手段。MRI和MRS可以用来提供关于组织成分、形态和功能的独特有价值的信息，以及对许多潜在生物过程的定量描述。不幸的是，我们目前的系统排除了对MR研究的几个新途径的探索，一些新的应用超出了我们当前机器的能力。新系统将提供三个主要的具体优势。[1]它将能够实施新的方法，如在当前平台上无法实施的多频段采集，调查人员可以确保继续支持几年；[2]它的内径更大，因此我们可以想象目前被排除在研究之外的更大的患者，并实现更高的射频和主场均匀度。更大的内径对于满足我们当地人口的挑战以及允许对腹部、脊柱和乳房进行更多和更好的研究是必不可少的；[3]新的全数字架构可在RF线圈内直接转换MR信号，生成信噪比更高(40%)的图像。在这项应用中，我们有29名精选的研究人员，他们都是当前3T扫描仪的经验丰富的用户，在各种研究应用中。他们的研究项目主要分为四大类：(1)成像物理， 新的和改进的磁共振成像方法的发展：(2)癌症，MRI和MRS在诊断和临床治疗中的应用，包括开发成像生物标记物来评估治疗：(3)神经科学，以及结构和功能磁共振在正常和神经精神疾病条件下的大脑结构和功能组织研究中的应用：(4)代谢紊乱，以及先进磁共振方法在活体生理和生化研究中的开发和应用。这里描述的用户的项目将需要扫描仪可用时间的大约80%，其余时间将用于探索性研究和新方向。该扫描仪将在范德比尔特大学成像科学研究所内安装和管理，并将继续是一大批成像科学家的主要研究资源。该仪器将由一个由磁共振成像专家和支持人员组成的既定小组提供支持。已经为该系统的财政和技术支持及其管理制定了一项全面计划，并确保该系统得到强有力的机构支持和监督。

项目成果

A registration strategy to characterize DTI-observed changes in skeletal muscle architecture due to passive shortening.

一种配准策略，用于表征由于被动缩短而导致的 DTI 观察到的骨骼肌结构变化。

• DOI: 10.1101/2024.04.11.589123
• 发表时间: 2024
• 期刊: bioRxiv : the preprint server for biology
• 作者: Hooijmans,MelissaT;Lockard,CarlyA;Zhou,Xingyu;Coolbaugh,Crystal;PinedaGuzman,Roberto;Kersh,MarianaE;Damon,BruceM
• 通讯作者: Damon,BruceM

Reproducibility of liver iron concentration estimates in MRI through R2* measurement determined by least-squares curve fitting.

• DOI: 10.1002/acm2.13096
• 发表时间: 2020-12
• 期刊: Journal of applied clinical medical physics
• 影响因子: 2.1
• 作者: Headley AM;Grice JV;Pickens DR
• 通讯作者: Pickens DR

Minimal artifact actively shimmed metallic needles in MRI.

• DOI: 10.1002/mrm.28977
• 发表时间: 2022-01
• 期刊: Magnetic resonance in medicine
• 影响因子: 3.3
• 作者: Sengupta S;Yan X;Hoyt TL;Drake G;Gunderman A;Chen Y
• 通讯作者: Chen Y

Small volume blood-brain barrier opening in macaques with a 1 MHz ultrasound phased array.

使用 1 MHz 超声相控阵在猕猴中打开小体积血脑屏障。

• DOI: 10.1016/j.jconrel.2023.10.015
• 发表时间: 2023
• 期刊: Journal of controlled release : official journal of the Controlled Release Society
• 作者: Manuel,ThomasJ;Sigona,MichelleK;Phipps,MAnthony;Kusunose,Jiro;Luo,Huiwen;Yang,Pai-Feng;Newton,AllenT;Gore,JohnC;Grissom,William;Chen,LiMin;Caskey,CharlesF
• 通讯作者: Caskey,CharlesF