EB 2019 Symposium: The Environment and Gene Expression, Role of the Epigenome

摘要 该提案描述了一个由五名专家演讲者组成的3小时研讨会 以及来自学员的四个题为环境与基因的简短演讲 表观基因组的表达和作用。基因和基因之间的相互作用 一段时间以来，环境一直是一个重要的焦点话题。的目标是 实现给定环境暴露与给定环境暴露之间的直接联系 基因表达的改变，然后到给定的表型一直难以捉摸 然而。此外，环境破坏的跨代效应也很好 记录在案，但不完全理解。作为周围的信息 基因表达的表观遗传调控越来越强，尝试使用 环境变化的表观遗传控制作为暴露和 疾病。近年来，这种联系在经验上得到了加强。探索 表观基因组的环境变化在人类疾病中的作用是 拟议专题讨论会的主题。该研讨会已获大会批准 美国实验病理学学会(ASIP)项目委员会 2019年4月6日至10日在佛罗里达州奥兰多举行的EB 2019年会议上。《公约》的具体目标 会议的目的是1)建立一个论坛，讨论最新的数据链接 已知的环境暴露对人群和 在有人参与和跨学科的环境中进行模型系统研究2) 让科学家从广泛的科学兴趣中了解分子 已知的内分泌紊乱和其他毒性暴露的机制 化学品暴露和3)促进MOST的合作活动的增长 目前围绕染色质景观的作用的实验领域 用最好的环境暴露科学来调控基因表达。 该研讨会将嵌入实验生物学年会 它通常有超过14,000名注册者，并将由 ASIP。

Abstract The proposal describes a 3-hour Symposium consisting of five expert presenters and four short talks from trainees entitled The Environment and Gene Expression, Role of the Epigenome. The interaction of genes and the environment has been an important focus topic for some time. The goal of achieving a direct connection between given environmental exposures to given gene expression alterations and then to a given phenotype has been elusive however. Moreover, transgenerational effects of environmental damage are well documented but not completely understood. As information surrounding epigenetic regulation of gene expression grows it is logical to attempt to use environmental alteration of epigenetic control as a link between exposure and disease. In recent years this link has been empirically strengthened. Exploring the role of environmental alteration of the epigenome in human disease is the subject of the proposed symposium. The symposium has been approved by the Program Committee of the American Society of Experimental Pathology (ASIP) at the EB 2019 meeting in Orlando FL April 6-10, 2019. The specific aims of the meeting are to 1) establish a forum for the discussion of the latest data linking specific alterations from known environmental exposure in both population and model system studies in a setting that is well attended and interdisciplinary 2) inform scientists from a broad range of scientific interests about the molecular mechanisms of endocrine disruption and other toxic exposures by known chemical exposures and 3) foster the growth of collaborative activity of the most current areas of experimentation around the role of chromatin landscape in regulation of gene expression with the best of environmental exposure science. The symposium will be embedded in the Experimental Biology annual meeting that typically has more than 14,000 registrants and will be under the aegis of the ASIP.