Hibbs -Association Between Intermittent Hypoxia and Later Respiratory Morbidity

希布斯 - 间歇性缺氧与后期呼吸系统疾病之间的关联

• 批准号: 9763640
• 负责人: Anna Maria Hibbs
• 金额: $ 56.89万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9763640
• 关键词: Age; Age-Months; Animal Model; Apnea; Asthma; Basic Science; Biochemical Markers; Biological Markers; Biomedical Engineering; Blood specimen; Breathing; Clinical; Clinical Trials; Collection; Data; Data Collection; Development; Disease; Enrollment; Environmental air flow; Event; Frequencies; Future; Gestational Age; Goals; Hospitalization; Hypoxia; Impairment; Incidence; Infant; Intervention; Lead; Length; Length of Stay; Life; Link; Lung; Measurement; Measures; Morbidity - disease rate; Mus; Neonatal; Neonatal Apneic Attack; Outcome; Oxidative Stress; Oxygen; Oxygen Therapy Care; Pathway interactions; Pattern; Pharmaceutical Preparations; Pregnancy; Premature Birth; Premature Infant; Prospective cohort study; Pulse Oximetry; Recovery; Research Personnel; Resistance; Resolution; Respiratory System; Retinopathy of Prematurity; Retrospective cohort; Risk; Rodent; Role; Serotonergic System; Serotonin; Signal Transduction; Smooth Muscle Actin Staining Method; Structure; Symptoms; Time; Urine; Wheezing; Work; cohort; experience; falls; follow-up; high risk; high risk population; improved; lung injury; meetings; novel; oxidant stress; oxidation; postnatal; premature; respiratory; respiratory smooth muscle; time interval

Project Summary Longer term respiratory morbidity remains a major consequence of preterm birth. We seek to characterize the association between immature respiratory control manifest as intermittent hypoxia [IH] and later respiratory morbidity in a cohort of preterm infants less than or equal to 30 weeks' gestation. Our hypotheses in Aims 1 and 2 are that IH episodes at one week and one month of life are significantly associated with prolonged duration of hospitalization and respiratory support, as well as a high incidence of wheezing disorders by six months adjusted age. In Aim 3 we hypothesize that low serotonin levels are associated with a high incidence of IH and a prolonged recovery of respiratory effort after onset of desaturation. Finally, in Aim 4 we hypothesize a temporal relationship between IH episodes and markers of oxidative stress determined by urine and blood samples. In prior studies we have demonstrated that apnea almost always precedes desaturation in preterm infants and have documented a novel association between retinopathy of prematurity, and both the duration of IH events and the time interval between IH events. From these data we speculate that it is both longer IH events and a distinct time interval of at least one minute between IH events that will be associated with respiratory morbidity and accompanying oxidative stress. This proposal provides a unique opportunity to quantify, for the first time, a relationship between IH and biomarkers of oxidation. We provide additional retrospective data that IH is associated with both increased length of stay and postnatal wheezing disorders, as well as a remarkable track record for both meeting enrollment goals and effective follow-up in prior clinical trials. Additionally, we have a strong track record for collection of continuous cardiorespiratory waveforms with bioengineering expertise in signal acquisition and processing that is ideally suited for multicenter data collection. In conclusion, our investigators' expertise in the measurement and analysis of respiratory and saturation waveforms, characterization of IH events, the basic science of respiratory control, and the measurement of clinical respiratory outcomes, makes us ideally poised to execute this single center, as well as multisite, proposal.

项目摘要 长期呼吸道疾病仍然是早产的主要后果。我们寻求 描述不成熟呼吸控制表现为间歇性 一组小于或等于30岁早产儿的缺氧[IH]和后期呼吸系统发病率 怀孕数周。我们在目标1和目标2中的假设是， 月的生活显着相关的住院时间延长， 呼吸支持，以及喘息性疾病的高发病率， 年龄在目标3中，我们假设低血清素水平与高发病率相关， IH和呼吸努力的恢复时间延长后，开始去饱和。最后，在目标4中， 假设IH发作和氧化应激标志物之间时间关系 通过尿液和血液样本测定。在先前的研究中，我们已经证明， 几乎总是在早产儿的去饱和之前，并记录了一种新的 早产儿视网膜病变与IH事件的持续时间和 IH事件之间的间隔。从这些数据中，我们推测，这既是更长的IH事件，也是一个 IH事件之间至少有一分钟的明显时间间隔， 呼吸道疾病和伴随的氧化应激。该提案提供了一个独特的 有机会量化，第一次，IH和氧化生物标志物之间的关系。 我们提供了额外的回顾性数据，表明IH与住院时间的增加有关， 和产后喘息障碍，以及一个显着的记录，这两个会议 入组目标和既往临床试验的有效随访。此外，我们有一个强大的 生物工程连续心肺波形采集跟踪记录 信号采集和处理方面的专业知识，非常适合多中心数据 收藏.总之，我们的研究人员在测量和分析方面的专业知识， 呼吸和饱和波形，IH事件的表征， 呼吸控制和临床呼吸结果的测量，使我们理想地 准备执行这个单一中心，以及多站点，提案。