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Patient-Oriented Research and Mentoring Program in Prematurity-Associated Pulmonary Morbidity

以患者为中心的早产儿相关肺部疾病研究和指导计划

基本信息

批准号：
10004719
负责人：
Anna Maria Hibbs
金额：
$ 11.96万
依托单位：
CASE WESTERN RESERVE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-01 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10004719
关键词：
2 year old Age Age-Months Apnea Breathing Clinical Clinical Research Data Degree program Development Developmental Delay Disorders Diet Dietary intake Disease Dose Enrollment Event Faculty Family Follow-Up Studies Frequencies Funding Future Goals Hospitalization Hypersensitivity Hypoxia Immune system Impairment Infant Intervention Lead Life Link Lung Measurable Measures Medical Mentors Mentorship Morbidity - disease rate Multicenter Studies Outcome Oxidative Stress Oxygen Oxygen Therapy Care Pathway interactions Pediatric Hospitals Population Pregnancy Premature Birth Premature Infant Protocols documentation Provider Questionnaires Recurrence Regimen Research Research Personnel Respiration Respiration Disorders Retinopathy of Prematurity Role Serotonin Site Sleep Sleep Apnea Syndromes Structure Supplementation Symptoms Techniques Testing Time Training Programs Vitamin D Vitamin D supplementation Wheezing animal data atopy case control clinically relevant cohort comparative effectiveness experience falls follow-up high risk human data immune function lung injury meetings neonatal lung injury neonatal period novel oxidant stress patient oriented research premature prevent programs pulmonary function racial difference respiratory respiratory morbidity response time interval

项目摘要

PROJECT SUMMARY Dr. Hibbs proposes a patient-oriented research and mentorship program focusing on prematurity-associated pulmonary morbidity. She has a strong track-record for POR research and mentorship and availability of future mentees from junior faculty and trainees at Rainbow Babies and Children's Hospital (RBC) and CWRU; she will integrate mentees in the newly proposed project as well as other currently funded local and multi-center studies. Longer term respiratory morbidity and neurodevelopmental delay are major consequences of preterm birth. In the proposed study, we seek to characterize the association between immature respiratory control, manifesting as intermittent hypoxia (IH), and later respiratory and neurodevelopmental morbidity in a cohort of preterm infants less than or equal to 30 weeks' gestation. This proposal is a two-year follow-up study of the Pre-Vent Case Western Reserve (CWRU) site protocol, and represents a unique opportunity to pair longer-term clinically relevant outcomes, as measured by validated questionnaires, with an already-funded study using sophisticated techniques to capture and analyze early life IH events. Our hypotheses are that IH episodes at one week and one month of life are significantly associated with recurrent wheezing, sleep disordered breathing, and neurodevelopmental delay. In prior studies we have demonstrated that apnea almost always precedes desaturation in preterm infants and have documented a novel association between retinopathy of prematurity, and both the duration of IH events and the time interval between IH events. From these data we speculate that it is not only longer and more frequent IH events, but also distinct time interval of at least one minute between IH events, that will be associated with long-term clinical morbidities. We provide additional retrospective data that IH is associated with wheezing disorders, as well as a remarkable track record for both meeting enrollment goals and effective follow-up in prior clinical studies.

项目总结