Eunice Kennedy Shriver NICHD Cooperative Multicenter Neonatal Research Network

 描述（由申请人提供）：NICHD于1986年建立了新生儿重症监护病房（NRN）多中心网络，以快速设计，实施和发布高优先领域的临床试验。我们是自1986年以来仅有的两个成功参加每一轮比赛的中锋之一。我们对继续参加全国重建网络的前景感到兴奋。我们将证明，我们将继续毫无疑问地满足作为一个中心的所有要求。我们的工作人员在专业知识和生产力方面是无与伦比的，我们在所有试验和随访中一贯的高入组率证明了这一点 率超过90%。我们的注册人数一直是NRN中最高的，因为我们的专业人员全天候招聘，包括晚上，周末和假期。此外，我们的医疗和护理人员都坚信，通过研究可以改善患者护理，鼓励家属参与，并致力于严格遵守协议。我们的大规模多样化的先天性分娩服务，基本上没有损失的背部运输是理想的新生儿临床试验。我们有一个完整的儿科专家小组（包括积极参与的儿科外科，眼科和心脏病学的共同研究者）可用于进行试验。此外，CWRU还带来了儿科药理学，肺病学，生物医学工程，呼吸治疗以及CWRU CTSA的蛋白质组学和基因组学核心的特殊专业知识，这些都丰富了NRN。我们不仅展示了与其他中心合作的卓越能力，而且承担了许多领导角色。我们为长期随访设定了标准。全国各地的中心，实际上在世界各地，已经实施了CWRU方法来跟踪前早产儿到成年，保持良好。CWRU通过指导新的中心，使他们能够快速实施IRB提交、入组和遵守方案，不断提高NRN在每个周期过渡期间的生产力。我们有最坚定的机构支持与空间和资源的承诺，从CWRU医学院，大学医院病例医疗中心，儿科和生殖生物学部门和新生儿和产妇胎儿医学部门。我们热切期待NRN的下一个周期，并将继续引领和创新。

 DESCRIPTION (provided by applicant): The Multicenter Network of Neonatal Intensive Care Units (NRN) was established by the NICHD in 1986 to rapidly design, conduct and publishes clinical trials in high priority areas. We are one of only two centers that have successfully competed in every round since 1986. We are excited by the prospect of continuing our participation in the NRN. We will demonstrate that we continue to unquestionably meet all the requirements for inclusion as a center. Our personnel are unparalleled in their expertise and productivity as evidenced by our consistently high enrollment rates in all trials and our follow-up rates which exceed 90%. Our enrollments are consistently among the highest in the NRN because our dedicated personnel recruit 24/7 including nights, weekends and holidays. In addition, both our medical and nursing staffs believe unequivocally that patient care is improved through research, encourage families to participate, and are committed to meticulous adherence to protocols. Our large diverse inborn delivery service with essentially no loss to back transport is ideal for neonatal clinical trials. We have a full complement of pediatric subspecialists (including actively engaged co-investigators in Pediatric Surgery, Ophthalmology and Cardiology) available to conduct trials. In addition, CWRU brings special expertise in Pediatric Pharmacology, Pulmonology, Biomedical Engineering, Respiratory Therapy, and the Proteomics and Genomics Cores at the CWRU CTSA that all enrich the NRN. We have not only shown exceptional ability to collaborate with other centers, but we have assumed many leadership roles. We have set the bar for long term follow-up. Centers across the country, and indeed across the world, have implemented CWRU methods to track former preterm infants into adulthood with excellent retention. CWRU has consistently enhanced the productivity of the NRN at every cycle transition by mentoring new centers to enable them to rapidly implement IRB submissions, enrollment, and adherence to protocols. We have the firmest institutional backing with commitments of space and resources from the CWRU School of Medicine, University Hospitals Case Medical Center, the Departments of Pediatrics and Reproductive Biology and the Divisions of Neonatology and Maternal Fetal Medicine. We eagerly anticipate the next cycle of the NRN and will continue to lead and innovate.