Cuff Electrodes with Soft Wire Electrical Leads

带软线电引线的袖带电极

• 批准号: 9766420
• 负责人: Brady John Clapsaddle
• 金额: $ 24.51万
• 依托单位: TDA RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2022-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9766420
• 关键词: Acute; Biomedical Engineering; Carbon; Carbon Nanotubes; Charge; Chronic; Cicatrix; Contralateral; Custom; Development; Devices; Disease; Effectiveness; Electric Stimulation Therapy; Electrodes; Evaluation; Failure; Formulation; Goals; Government; Histocompatibility; Histology; Implant; In Vitro; Inflammatory Response; Injections; Longevity; Manufacturer Name; Market Research; Mechanics; Metals; Methods; Microelectrodes; Modeling; Modulus; Movement; Nature; Nerve; Performance; Peripheral Nervous System; Persons; Phase; Pliability; Polymers; Rattus; Research; Research Personnel; Small Business Technology Transfer Research; Stress; Stretching; Techniques; Technology; Testing; Time; Tissues; Universities; clinical application; design; elastomeric; electric impedance; flexibility; implantation; improved; in vivo; novel; product development; sciatic nerve; soft tissue

Project Summary/Abstract “Development of a Nerve Cuff Electrode from Soft and Elastomeric Conducting Wires STTR Phase I Application” PI: Brady Clapsaddle, TDA Research, Inc. Bio-electronic interfaces are used in a wide array of applications for recording and providing electrical impulses to treat disease. One common interface device for the PNS is the cuff electrode. Current cuff electrodes have many failure modes, most commonly breakage of the brittle metal microwire leads during implantation or regular movement. Stiff metal wires also irritate soft tissue, leading to inflammatory response and scarring. Researchers and clinicians have realized that increased lifetime and ease of implantation of cuff electrodes would greatly benefit research and electrotherapy, prompting advances in commercial cuff electrodes in recent years. The development of materials that are easier to implant and have better tissue compatibility has been at the forefront of these advances. These new cuffs however, still mainly use metal microwires for contact with the tissue. Conducting polymers and carbonaceous materials offer better mechanical compatibility with tissues than their metal counterparts. TDA has recently developed a soft, elastomeric wire material that is compatible with tissue. Furthermore, TDA's wires are elastic, stretching to >200% of their original size (depending on formulation), and thus TDA's soft wires have the potential to eliminate many failure modes of traditional cuff electrodes by replacing brittle metal microwires. Due to their stretchable, pliable nature, TDA's soft wires can withstand the stress of implantation and result in robust interfaces with hardware. Using these materials, we propose to develop novel cuff electrodes with soft polymeric electrical leads to improve durability, ease of implantation, and tissue compatibility of cuff electrodes for applications in the peripheral nervous system (PNS). Our approach is to fabricate cuff electrodes with flexible conducting wires. Once fabricated, our collaborators at the University of Pittsburgh will demonstrate implantability in the PNS, acute in vivo functionality, and long term performance in a chronic in vivo study.

项目总结/摘要 STTR Phase I“ 应用程序” 主要研究者：布雷迪，TDA研究公司 生物电子接口用于记录和提供电脉冲的广泛应用 来治疗疾病。PNS的一种常见接口设备是袖带电极。当前袖带电极具有 许多失效模式，最常见的是植入过程中脆性金属微丝导线的断裂， 有规律的运动硬金属丝也会刺激软组织，导致炎症反应和瘢痕形成。 研究人员和临床医生已经意识到，增加袖带电极的使用寿命和植入的容易性 将极大地有利于研究和电疗，促进了最近商业袖带电极的发展。 年更容易植入并具有更好组织相容性的材料的开发一直在进行， 这些进步的最前沿。然而，这些新的袖带仍然主要使用金属微丝来接触 组织。导电聚合物和碳质材料与组织具有更好的机械相容性 比他们的金属同行。TDA最近开发了一种柔软的弹性线材料， 用纸巾。此外，TDA的电线是弹性的，可拉伸至其原始尺寸的>200%（取决于 因此，TDA的软线有可能消除传统袖带的许多失效模式 电极通过替换脆性金属微丝。由于其可拉伸，柔韧的性质，TDA的软电线可以 承受植入的应力并与硬件形成坚固的接口。使用这些材料，我们 建议开发具有软聚合物电引线的新型袖带电极，以提高耐久性、易于 用于周围神经系统的袖带电极的植入和组织相容性 （PNS）.我们的方法是用柔性导线制作袖带电极。一旦捏造，我们的 匹兹堡大学的合作者将证明PNS的可植入性， 功能性和长期性能。