2/2 Southeast Partnership for Improving Research & Training in Cancer Health Disparities

2/2 东南部改善研究伙伴关系

• 批准号: 9767095
• 负责人: Paula Elizabeth Gregory
• 金额: $ 24.04万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-21 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9767095
• 关键词: African; African American; Applications Grants; Area; Awareness; Basic Science; Behavior; Biological; Cancer Biology; Cancer Center; Cancer Center Support Grant; Caring; Catchment Area; Censuses; Chemicals; Clinical; Clinical Research; Collaborations; Communities; Comprehensive Cancer Center; Correlation Studies; Data; Databases; Development; Diagnosis; Education; Education and Outreach; Educational Curriculum; Ethnic Origin; European; Evolution; Expression Profiling; Florida; Foundations; Funding; Galanin; Gene Expression; Genetic; Genomics; Geographic Locations; Goals; Health; Health Professional; Health Sciences; Hispanics; Home environment; Hurricane; Immunity; Immunology; Inflammation; Infrastructure; Institution; Joints; Language; Latina; Lead; Location; Louisiana; Malignant Neoplasms; Medical Students; Minority; Mission; Mississippi; Molecular; Molecular Biology; NCI-Designated Cancer Center; Native Americans; Outcome; Patients; Philosophy; Pilot Projects; Population; Population Heterogeneity; Population Research; Prevention; Production; RNA methylation; Race; Research; Research Institute; Research Personnel; Research Project Grants; Research Training; Resource Sharing; Resources; Rural; Science; Specimen; Students; Technology; Tissue Microarray; Translational Research; Underrepresented Populations; Underrepresented Students; Underserved Population; Universities; anticancer research; base; biobank; breast cancer genomics; cancer care; cancer education; cancer epidemiology; cancer health disparity; cancer immunotherapy; cancer prevention; cancer risk; cancer stem cell; career development; education research; epigenomics; ethnic diversity; ethnic minority population; experience; health disparity; improved; inter-institutional; literacy; malignant breast neoplasm; member; minority communities; minority-serving hospitals; molecular subtypes; new therapeutic target; next generation; novel; novel marker; outcome forecast; patient population; precision medicine; precision oncology; programs; racial and ethnic; racial diversity; repository; summer research; tool; transcriptome sequencing; treatment response; undergraduate student

The Southeast Partnership for Improving Research & Training in Cancer Health Disparities (SPIRIT- CHD) unites the Louisiana State University Health Sciences Center (LSUHSC), an institution serving underserved populations and underrepresented students (ISUPS), and the NCI-designated Moffitt Cancer Center (MCC) to advance translational research on the biological mechanisms of cancer health disparities focusing on biospecimen-based research and precision medicine. It also seeks to establish a joint cancer research education program focused on biobanking and precision medicine education. LSUHSC serves a region characterized by an underserved African-American population, and rampant cancer health disparities in the wake of Hurricane Katrina. This region has several growing racial/ethnic minority populations. After Hurricane Katrina, the Hispanic population in Louisiana doubled and is now the fastest growing ethnic minority. MCC is located in Tampa, Florida and serves an increasingly wide catchment area characterized by a population diverse in regard to age, race/ethnicity, language and literacy, and is home to an increasing Latino population. Precision medicine research requires: a well-managed, ethnically and racially diverse biospecimen repository; state of the art technology in genomics, epigenomics and ancestry analysis; availability of language, cultural and literacy specific educational tools and resources; and a research education infrastructure that promotes a pipeline of trainees in cancer disparities research. MCC is a national leader and pioneer in these areas, has highly integrated research programs, and seeks to expand the diversity of their biospecimen research endeavors. This partnership is based on two Specific Aims. Specific Aim 1: Plan and execute two collaborative pilot research projects. The first pilot research project focuses on breast cancer genomics, studying biospecimens from Hispanic/Latina patients of mixed genetic ancestry (African, Native American, European) by RNA sequencing (RNASeq) and methylation analysis, to study correlations between molecular subtypes, gene expression profiles, clinical outcomes and ancestry. This project will support the career development of racial/ethnic minority early-stage investigators at LSUHSC and MCC. Specific Aim 2: Plan a collaborative three-pronged cancer research education program that includes: 1) a hands-on summer research experience for undergraduate and medical students; 2) delivery of a curriculum to those students focusing on biobanking, precision medicine and cancer health disparities; and 3) expansion of outreach education to our respective communities about biobanking, precision medicine and cancer health disparities. The combination of these collaborative partnership activities is expected to offer mutual benefit to each institution to impact cancer health disparities, inspire the next generation of researchers, and rapidly lead to the submission of competitive grant applications. Importantly, our main collaborative goal is to bring the benefits of cancer research advancements to underserved communities.

东南伙伴关系，以改善研究和培训在癌症健康差异（SPIRIT- CHD）联合路易斯安那州立大学健康科学中心（LSUHSC），一个服务于 服务不足的人群和代表性不足的学生（IUPS），以及NCI指定的莫菲特癌症 中心（MCC）推进癌症健康差异的生物学机制的转化研究 专注于基于生物医学的研究和精准医学。它还试图建立一个联合癌症 研究教育计划侧重于生物银行和精准医学教育。LSUHSC服务于 该地区的特点是非洲裔美国人人口服务不足， 卡特里娜飓风过后。该地区有几个不断增长的种族/少数民族人口。后 卡特里娜飓风过后，路易斯安那州的西班牙裔人口翻了一番，现在是增长最快的少数民族。 MCC位于佛罗里达的坦帕，服务范围日益扩大， 人口在年龄，种族/民族，语言和识字方面多样化，并且是越来越多的拉丁美洲人的家园 人口精准医学研究需要：管理良好、种族和人种多样化的生物标本 知识库;基因组学、表观基因组学和祖先分析方面的最新技术;语言的可用性， 文化和扫盲方面的具体教育工具和资源;以及研究教育基础设施， 促进癌症差异研究的受训者管道。MCC是这些领域的全国领导者和先驱 地区，具有高度综合的研究计划，并寻求扩大其生物标本的多样性 研究的努力。这种合作关系基于两个具体目标。具体目标1：计划并执行两个 合作试点研究项目。第一个试点研究项目集中在乳腺癌基因组学， 研究来自混合遗传血统的西班牙裔/拉丁裔患者（非洲人，美洲土著人， 欧洲）通过RNA测序（RNASeq）和甲基化分析，研究分子间的相关性， 亚型、基因表达谱、临床结果和祖先。该项目将支持职业生涯 在LSUHSC和MCC培养种族/少数民族早期研究者。具体目标2：计划a 合作三管齐下的癌症研究教育计划，包括：1）动手夏季研究 本科生和医学生的经验; 2）向这些学生提供课程，重点是 生物库、精准医学和癌症健康差异;以及3）将外展教育扩大到我们的 关于生物银行，精准医疗和癌症健康差异的各自社区。相结合 预计这些合作伙伴关系活动将为每个机构带来互利， 癌症健康的差异，激励下一代的研究人员，并迅速导致提交 有竞争力的补助金申请。重要的是，我们的主要合作目标是将癌症的益处 为服务不足的社区提供研究成果。