2/2 Southeast Partnership for Improving Research & Training in Cancer Health Disparities

2/2 东南部改善研究伙伴关系

• 批准号: 9418804
• 负责人: Paula Elizabeth Gregory
• 金额: $ 25.6万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-21 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9418804
• 关键词: African; African American; Age; Applications Grants; Area; Awareness; Basic Science; Behavior; Biological; Cancer Biology; Cancer Center; Cancer Center Support Grant; Caring; Catchment Area; Censuses; Chemicals; Clinical; Clinical Research; Collaborations; Communities; Comprehensive Cancer Center; Correlation Studies; Data; Databases; Development; Diagnosis; Education; Education and Outreach; Educational Curriculum; Ethnic Origin; European; Evolution; Florida; Foundations; Funding; Galanin; Gene Expression; Genetic; Genomics; Geographic Locations; Goals; Health; Health Professional; Health Sciences; Hispanics; Home environment; Hurricane; Immunity; Immunology; Inflammation; Institution; Joints; Language; Latina; Lead; Location; Louisiana; Malignant Neoplasms; Medical Students; Methylation; Minority; Mission; Mississippi; Molecular; Molecular Biology; Molecular Profiling; NCI-Designated Cancer Center; Native Americans; Outcome; Patients; Philosophy; Pilot Projects; Population; Population Heterogeneity; Population Research; Prevention; Production; Race; Research; Research Infrastructure; Research Institute; Research Personnel; Research Project Grants; Research Training; Resource Sharing; Resources; Rural; Science; Specimen; Students; Technology; Tissue Microarray; Translational Research; Underrepresented Populations; Underrepresented Students; Underserved Population; Universities; anticancer research; base; biobank; cancer care; cancer education; cancer epidemiology; cancer genomics; cancer health disparity; cancer immunotherapy; cancer prevention; cancer risk; cancer stem cell; career development; education research; epigenomics; ethnic diversity; ethnic minority population; experience; health disparity; improved; inter-institutional; literacy; malignant breast neoplasm; member; minority communities; minority-serving hospitals; molecular subtypes; new therapeutic target; next generation; novel; novel marker; outcome forecast; patient population; precision medicine; precision oncology; programs; racial and ethnic; racial diversity; repository; summer research; tool; transcriptome sequencing; treatment response; undergraduate student

The Southeast Partnership for Improving Research & Training in Cancer Health Disparities (SPIRIT- CHD) unites the Louisiana State University Health Sciences Center (LSUHSC), an institution serving underserved populations and underrepresented students (ISUPS), and the NCI-designated Moffitt Cancer Center (MCC) to advance translational research on the biological mechanisms of cancer health disparities focusing on biospecimen-based research and precision medicine. It also seeks to establish a joint cancer research education program focused on biobanking and precision medicine education. LSUHSC serves a region characterized by an underserved African-American population, and rampant cancer health disparities in the wake of Hurricane Katrina. This region has several growing racial/ethnic minority populations. After Hurricane Katrina, the Hispanic population in Louisiana doubled and is now the fastest growing ethnic minority. MCC is located in Tampa, Florida and serves an increasingly wide catchment area characterized by a population diverse in regard to age, race/ethnicity, language and literacy, and is home to an increasing Latino population. Precision medicine research requires: a well-managed, ethnically and racially diverse biospecimen repository; state of the art technology in genomics, epigenomics and ancestry analysis; availability of language, cultural and literacy specific educational tools and resources; and a research education infrastructure that promotes a pipeline of trainees in cancer disparities research. MCC is a national leader and pioneer in these areas, has highly integrated research programs, and seeks to expand the diversity of their biospecimen research endeavors. This partnership is based on two Specific Aims. Specific Aim 1: Plan and execute two collaborative pilot research projects. The first pilot research project focuses on breast cancer genomics, studying biospecimens from Hispanic/Latina patients of mixed genetic ancestry (African, Native American, European) by RNA sequencing (RNASeq) and methylation analysis, to study correlations between molecular subtypes, gene expression profiles, clinical outcomes and ancestry. This project will support the career development of racial/ethnic minority early-stage investigators at LSUHSC and MCC. Specific Aim 2: Plan a collaborative three-pronged cancer research education program that includes: 1) a hands-on summer research experience for undergraduate and medical students; 2) delivery of a curriculum to those students focusing on biobanking, precision medicine and cancer health disparities; and 3) expansion of outreach education to our respective communities about biobanking, precision medicine and cancer health disparities. The combination of these collaborative partnership activities is expected to offer mutual benefit to each institution to impact cancer health disparities, inspire the next generation of researchers, and rapidly lead to the submission of competitive grant applications. Importantly, our main collaborative goal is to bring the benefits of cancer research advancements to underserved communities.

东南改善癌症健康差异研究与培训伙伴关系（SPIRIT-）