2/2 Southeast Partnership for Improving Research & Training in Cancer Health Disparities

2/2 东南部改善研究伙伴关系

• 批准号: 10005277
• 负责人: Paula Elizabeth Gregory
• 金额: $ 24.78万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-21 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10005277
• 关键词: African; African American; Applications Grants; Area; Awareness; Basic Science; Behavior; Biological; Biological Specimen Banks; Cancer Biology; Cancer Center; Cancer Center Support Grant; Caring; Catchment Area; Censuses; Chemicals; Clinical; Clinical Research; Collaborations; Communities; Comprehensive Cancer Center; Correlation Studies; Data; Databases; Development; Diagnosis; Education; Education and Outreach; Educational Curriculum; Ethnic Origin; European; Evolution; Expression Profiling; Florida; Foundations; Funding; Galanin; Gene Expression; Genetic; Genomics; Geographic Locations; Goals; Health; Health Professional; Health Sciences; Hispanics; Home environment; Hurricane; Immunology; Inflammation; Infrastructure; Institution; Joints; Language; Latina; Lead; Location; Louisiana; Malignant Neoplasms; Medical Students; Minority; Mission; Mississippi; Molecular; Molecular Biology; NCI-Designated Cancer Center; Native Americans; Outcome; Patients; Philosophy; Pilot Projects; Population; Population Heterogeneity; Population Research; Prevention; Production; RNA methylation; Race; Research; Research Institute; Research Personnel; Research Project Grants; Research Training; Resource Sharing; Resources; Rural; Science; Specimen; Students; Technology; Tissue Microarray; Translational Research; Tumor Immunity; Underrepresented Populations; Underrepresented Students; Underserved Population; Universities; ancestry analysis; anticancer research; base; biobank; breast cancer genomics; cancer care; cancer education; cancer epidemiology; cancer health disparity; cancer immunotherapy; cancer prevention; cancer risk; cancer stem cell; career development; education research; epigenomics; ethnic diversity; ethnic minority population; experience; health disparity; improved; inter-institutional; literacy; malignant breast neoplasm; member; minority communities; minority-serving hospitals; molecular subtypes; new therapeutic target; next generation; novel; novel marker; outcome forecast; patient population; precision medicine; precision oncology; programs; racial and ethnic; racial diversity; summer research; tool; transcriptome sequencing; treatment response; undergraduate student

The Southeast Partnership for Improving Research & Training in Cancer Health Disparities (SPIRIT- CHD) unites the Louisiana State University Health Sciences Center (LSUHSC), an institution serving underserved populations and underrepresented students (ISUPS), and the NCI-designated Moffitt Cancer Center (MCC) to advance translational research on the biological mechanisms of cancer health disparities focusing on biospecimen-based research and precision medicine. It also seeks to establish a joint cancer research education program focused on biobanking and precision medicine education. LSUHSC serves a region characterized by an underserved African-American population, and rampant cancer health disparities in the wake of Hurricane Katrina. This region has several growing racial/ethnic minority populations. After Hurricane Katrina, the Hispanic population in Louisiana doubled and is now the fastest growing ethnic minority. MCC is located in Tampa, Florida and serves an increasingly wide catchment area characterized by a population diverse in regard to age, race/ethnicity, language and literacy, and is home to an increasing Latino population. Precision medicine research requires: a well-managed, ethnically and racially diverse biospecimen repository; state of the art technology in genomics, epigenomics and ancestry analysis; availability of language, cultural and literacy specific educational tools and resources; and a research education infrastructure that promotes a pipeline of trainees in cancer disparities research. MCC is a national leader and pioneer in these areas, has highly integrated research programs, and seeks to expand the diversity of their biospecimen research endeavors. This partnership is based on two Specific Aims. Specific Aim 1: Plan and execute two collaborative pilot research projects. The first pilot research project focuses on breast cancer genomics, studying biospecimens from Hispanic/Latina patients of mixed genetic ancestry (African, Native American, European) by RNA sequencing (RNASeq) and methylation analysis, to study correlations between molecular subtypes, gene expression profiles, clinical outcomes and ancestry. This project will support the career development of racial/ethnic minority early-stage investigators at LSUHSC and MCC. Specific Aim 2: Plan a collaborative three-pronged cancer research education program that includes: 1) a hands-on summer research experience for undergraduate and medical students; 2) delivery of a curriculum to those students focusing on biobanking, precision medicine and cancer health disparities; and 3) expansion of outreach education to our respective communities about biobanking, precision medicine and cancer health disparities. The combination of these collaborative partnership activities is expected to offer mutual benefit to each institution to impact cancer health disparities, inspire the next generation of researchers, and rapidly lead to the submission of competitive grant applications. Importantly, our main collaborative goal is to bring the benefits of cancer research advancements to underserved communities.

改善癌症健康差异研究和培训东南伙伴关系(SPIRIT- CHD)联合路易斯安那州立大学健康科学中心(LSUHSC)，这是一家为 服务不足的人群和代表不足的学生(ISUPS)，以及NCI指定的莫菲特癌症 中心(MCC)推进癌症健康差异生物学机制的转化研究 专注于以生物有机磷为基础的研究和精准医学。它还寻求建立一种联合癌症 研究性教育计划侧重于生物库和精准医学教育。LSUHSC服务于 该地区的特点是非洲裔美国人服务不足，癌症健康差距在 卡特里娜飓风过后。这一地区有几个不断增长的种族/少数民族人口。之后 卡特里娜飓风过后，路易斯安那州的拉美裔人口翻了一番，现在是增长最快的少数民族。 MCC位于佛罗里达州坦帕市，服务范围越来越广，其特点是 人口在年龄、种族/族裔、语言和识字方面多样化，拉丁裔人数不断增加 人口。精确医学研究需要：一个管理良好、种族和种族多样化的生物谱系 知识库；基因组学、表观基因组学和祖先分析的最新技术；语言的可用性， 针对文化和扫盲的教育工具和资源；以及研究教育基础设施， 促进癌症差异研究实习生的渠道。MCC是这些领域的全国领导者和先驱 ，拥有高度一体化的研究方案，并寻求扩大其生物谱系的多样性 研究工作。这一伙伴关系基于两个具体目标。具体目标1：规划和执行两个 协作先导研究项目。第一个试点研究项目集中在乳腺癌基因组学上， 研究西班牙裔/拉丁裔混合血统患者的生物标本(非洲人，美洲原住民， 通过RNA测序(RNAseq)和甲基化分析，研究分子间的相关性 亚型、基因表达谱、临床结果和血统。这个项目将支持职业生涯 发展LSUHSC和MCC的种族/少数民族早期调查人员。具体目标2：计划a 协作性三管齐下的癌症研究教育计划，包括：1)实际操作的夏季研究 为本科生和医学生提供经验；2)向这些学生提供课程，重点是 生物库、精准医学和癌症健康差距；以及3)将外展教育扩展到我们的 关于生物库、精准医学和癌症健康差距的各自社区。组合在一起 这些合作伙伴关系活动预计将为每个机构提供互惠互利的影响 癌症健康差异，激励下一代研究人员，并迅速导致提交 竞争性拨款申请。重要的是，我们的主要合作目标是将癌症的好处 对服务不足的社区的研究进展。

项目成果

Asthma status moderates the relationship between neighbourhood disadvantage and obesity in African American adolescent females.

哮喘状况调节了非裔美国青春期女性的邻里劣势与肥胖之间的关系。

• DOI: 10.1002/osp4.370
• 发表时间: 2019
• 期刊: Obesity science & practice
• 影响因子: 2.2
• 作者: Cahill,LauraM;Fisher,KivaA;Robinson,WilliamT;Beiter,KaylinJ;Zabaleta,Jovanny;Tseng,TungS;Kepper,MauraM;Skizim,MegK;Griffiths,LaurenA;Uddo,RobertB;Pelligrino,NicoleE;Maronge,JacobM;Happel,Kyle;Scribner,Richard;Sothern
• 通讯作者: Sothern

Ancestry as a potential modifier of gene expression in breast tumors from Colombian women.

祖先是哥伦比亚妇女乳腺肿瘤中基因表达的潜在修饰剂。

• DOI: 10.1371/journal.pone.0183179
• 发表时间: 2017
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Serrano-Gómez SJ;Sanabria-Salas MC;Garay J;Baddoo MC;Hernández-Suarez G;Mejía JC;García O;Miele L;Fejerman L;Zabaleta J
• 通讯作者: Zabaleta J

Advanced bioinformatic analysis and pathway prediction of NSCLC cells upon cisplatin resistance.

• DOI: 10.1038/s41598-021-85930-y
• 发表时间: 2021-03-22
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Hossian AKMN;Zahra FT;Poudel S;Abshire CF;Polk P;Garai J;Zabaleta J;Mikelis CM;Mattheolabakis G
• 通讯作者: Mattheolabakis G

New Insights into Avian Infectious Bronchitis Virus in Colombia from Whole-Genome Analysis.

• DOI: 10.3390/v14112562
• 发表时间: 2022-11-19
• 期刊: Viruses
• 作者: Ramirez-Nieto G;Mir D;Almansa-Villa D;Cordoba-Argotti G;Beltran-Leon M;Rodriguez-Osorio N;Garai J;Zabaleta J;Gomez AP
• 通讯作者: Gomez AP

Comparative analysis of miRNA profile in human dendritic cells infected with respiratory syncytial virus and human metapneumovirus.

• DOI: 10.1186/s13104-018-3541-0
• 发表时间: 2018-07-03
• 期刊: BMC research notes
• 影响因子: 1.8
• 作者: Baños-Lara MDR;Zabaleta J;Garai J;Baddoo M;Guerrero-Plata A
• 通讯作者: Guerrero-Plata A