Translational Reprogramming by Regulatory T Cells

调节性 T 细胞的翻译重编程

基本信息

  • 批准号:
    9765776
  • 负责人:
  • 金额:
    $ 27.29万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-01-04 至 2020-12-31
  • 项目状态:
    已结题

项目摘要

Project Summary Regulatory T cells (Tregs) play an indispensable role in maintaining immunological tolerance to self-antigens and in suppressing excessive immune responses deleterious to the host by exerting a suppressive program towards a wide variety of target immune cells. However, the intracellular molecular events that mediate such suppression in target cells in still poorly understood. In this study, we will investigate the molecular nature of this suppression program with the central hypothesis that regulation of the translational machinery and specific mRNA translation control is at the core of this reprogramming event. We will utilize a novel genetic tool that allows immunopurification of ribosomes in virtually any immune cell type in both in vitro and in vivo immune models called ‘RiboTag.’ Using RiboTag, we will capture the genome-wide translatome (all mRNAs being translated in time and space) during Treg-dependent immunological tolerance breakdown. We will further investigate the mechanism of such mRNA transcript-specific translation control with the hypothesis that the trans-acting translation regulatory protein factors are modulated in target cells encountered by Tregs. The RiboTag mediated immunopurification of ribosomes followed by mass spectrometry based proteomics will delineate such changes in the riboproteome (the ribosome itself or ribosome-associated factors) endowed by Treg encounter in target cells. These studies will break new ground in understanding a novel layer of gene expression control imposed by Tregs, a critical component in our immune system essential for immunological tolerance.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Ram Savan其他文献

Ram Savan的其他文献

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{{ truncateString('Ram Savan', 18)}}的其他基金

Prenylation in antiviral immunity
抗病毒免疫中的异戊二烯化
  • 批准号:
    10647533
  • 财政年份:
    2023
  • 资助金额:
    $ 27.29万
  • 项目类别:
The splicing factor CELF2 suppresses RNA ligands sensed by RIG-I-like receptor
剪接因子CELF2抑制RIG-I样受体感知的RNA配体
  • 批准号:
    10654469
  • 财政年份:
    2023
  • 资助金额:
    $ 27.29万
  • 项目类别:
Regulation of cardiomyocyte inflammation during viral infection
病毒感染过程中心肌细胞炎症的调节
  • 批准号:
    10244888
  • 财政年份:
    2020
  • 资助金额:
    $ 27.29万
  • 项目类别:
Regulation of cardiomyocyte inflammation during viral infection
病毒感染过程中心肌细胞炎症的调节
  • 批准号:
    9894164
  • 财政年份:
    2020
  • 资助金额:
    $ 27.29万
  • 项目类别:
Functional insights into the IRF5 genetic variants marking SLE risk.
对标记 SLE 风险的 IRF5 遗传变异的功能见解。
  • 批准号:
    9116776
  • 财政年份:
    2015
  • 资助金额:
    $ 27.29万
  • 项目类别:
Functional insights into the IRF5 genetic variants marking SLE risk.
对标记 SLE 风险的 IRF5 遗传变异的功能见解。
  • 批准号:
    8968765
  • 财政年份:
    2015
  • 资助金额:
    $ 27.29万
  • 项目类别:
Novel regulatory mechanisms control IFNL3 expression during HCV infection
HCV 感染过程中控制 IFNL3 表达的新调控机制
  • 批准号:
    8990447
  • 财政年份:
    2014
  • 资助金额:
    $ 27.29万
  • 项目类别:
Novel regulatory mechanisms control IFNL3 expression during HCV infection
HCV 感染过程中控制 IFNL3 表达的新调控机制
  • 批准号:
    8611757
  • 财政年份:
    2014
  • 资助金额:
    $ 27.29万
  • 项目类别:
Novel regulatory mechanisms control IFNL3 expression during HCV infection
HCV 感染过程中控制 IFNL3 表达的新调控机制
  • 批准号:
    9273703
  • 财政年份:
    2014
  • 资助金额:
    $ 27.29万
  • 项目类别:

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