SPORE for Translational Approaches to Brain Cancer
SPORE 用于脑癌转化方法
基本信息
- 批准号:9766222
- 负责人:
- 金额:$ 213.9万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-08-17 至 2023-07-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdultAnimalsApoptosisAutophagocytosisBrainBrain NeoplasmsCellsClinicalClinical TrialsCollaborationsCombined Modality TherapyComplexCytolysisCytotoxic ChemotherapyDiagnosisDiseaseFacultyGenesGlioblastomaGoalsHumanImmunosuppressionImmunosuppressive AgentsImmunotherapyIncidenceIndividualIntracranial NeoplasmsInvestigationKynurenineMalignant - descriptorMalignant GliomaMalignant NeoplasmsMalignant neoplasm of brainMediator of activation proteinModelingMulticenter StudiesNanoconjugateNatureNeoplasmsNewly DiagnosedOperative Surgical ProceduresOrganPatient-Focused OutcomesPatientsPrimary Brain NeoplasmsProductionPublic HealthRNA InterferenceRadiationRadiation therapyRecordsRecurrenceResearchResearch PersonnelResearch Project GrantsResidual TumorsRodentSLEB2 geneScienceSmall Interfering RNASpherical Nucleic AcidsSurgically-Created Resection CavityTP53 geneTalentsTherapeuticTimeTissuesTreatment outcomeUrsidae FamilyViralVirusWorkantitumor effectbaseexperiencehumanized mouseimmune checkpoint blockadeimprovedimproved outcomeinhibitor/antagonistinterdisciplinary approachmembermultidisciplinarynanoparticlenanotherapeuticneoplastic cellnerve stem cellnovelnovel therapeuticsoncolytic virotherapyoutcome forecastparticlepre-clinical researchpreclinical studypreservationprogramsstandard carestandard of carestatisticssuccesssurvivorshiptemozolomidetranslational approachtumor
项目摘要
OVERVIEW: SUMMARY
The overall objective of the Northwestern Brain Tumor SPORE is to improve outcomes for brain tumor
patients. Statistics on brain tumor incidence indicate that more than 23,000 people will be diagnosed with a
brain tumor in the U.S. in 2017, and approximately 17,000 will succumb to their disease. Of the various primary
intracerebral neoplasms, glioblastoma (GBM) is the most common. GBM patients that receive standard-of-care
treatment have a median survival of 15 months, and 5-year survival is extremely rare. Progress in developing
better treatments for this lethal tumor has been disappointing. A major contributor to this lack of therapeutic
improvement is the delicate nature of the organ in which this cancer occurs. There are significant limitations to
how aggressively GBM patients can be treated surgically, and the efficacy of systemically administered
therapies are often compromised due to limited access to the brain. To address the public health problem that
is associated with glioblastoma, we have assembled a talented team of investigators with extensive
backgrounds in brain tumor research and therapy. All members of this team have professional records
indicating success in directing their own programs of research. Some 3+ years ago, these faculty initiated
group interactions in order to bring a team science approach to bear upon the study and treatment of GBM,
and for which a multidisciplinary approach is needed for achieving meaningful progress.
概述:总结
西北脑肿瘤孢子的总体目标是改善脑肿瘤的预后
患者关于脑肿瘤发病率的统计数据表明,超过23,000人将被诊断患有脑肿瘤。
2017年,美国将有大约17,000人死于脑瘤。各种主要的
在脑内肿瘤中,胶质母细胞瘤(GBM)是最常见的。接受标准治疗的GBM患者
治疗的中位生存期为15个月,5年生存期极为罕见。的成就
对这种致命肿瘤的更好治疗一直令人失望。这种缺乏治疗的主要原因是
改善是发生这种癌症的器官的微妙性质。有很大的限制,
如何积极GBM患者可以手术治疗,以及全身给药的疗效
由于进入大脑的途径有限,治疗常常受到损害。为了解决公共卫生问题,
与胶质母细胞瘤有关,我们已经组建了一个有才华的研究团队,
脑肿瘤研究和治疗的背景。这个团队的所有成员都有专业记录
这表明他们在指导自己的研究项目方面取得了成功。大约3年多前,这些教师发起了
小组互动,以使团队科学的方法承担对GBM的研究和治疗,
为此需要采取多学科办法,以取得有意义的进展。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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MACIEJ S LESNIAK其他文献
MACIEJ S LESNIAK的其他文献
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{{ truncateString('MACIEJ S LESNIAK', 18)}}的其他基金
phase 1 adaptive dose-escalation study of mycophenolate mofetil (MMF) in combination with temozolomide (TMZ) for patients with newly diagnosed glioblastoma
霉酚酸酯(MMF)联合替莫唑胺(TMZ)治疗新诊断胶质母细胞瘤患者的 1 期适应性剂量递增研究
- 批准号:
10468352 - 财政年份:2020
- 资助金额:
$ 213.9万 - 项目类别:
Arginine Metabolism Regulates Myeloid Immune Suppression in Glioblastoma
精氨酸代谢调节胶质母细胞瘤的骨髓免疫抑制
- 批准号:
10554277 - 财政年份:2020
- 资助金额:
$ 213.9万 - 项目类别:
Arginine Metabolism Regulates Myeloid Immune Suppression in Glioblastoma
精氨酸代谢调节胶质母细胞瘤的骨髓免疫抑制
- 批准号:
10331872 - 财政年份:2020
- 资助金额:
$ 213.9万 - 项目类别:
SPORE for Translational Approaches to Brain Cancer
SPORE 用于脑癌转化方法
- 批准号:
10224120 - 财政年份:2018
- 资助金额:
$ 213.9万 - 项目类别:
SPORE for Translational Approaches to Brain Cancer
SPORE 用于脑癌转化方法
- 批准号:
10478866 - 财政年份:2018
- 资助金额:
$ 213.9万 - 项目类别:
Neural Stem Cell Based Virotherapy for Malignant Glioma
基于神经干细胞的恶性胶质瘤病毒疗法
- 批准号:
10626393 - 财政年份:2018
- 资助金额:
$ 213.9万 - 项目类别:
Project 1: Neural Stem Cell Based Oncolytic Virotherapy of Malignant Glioma
项目1:基于神经干细胞的恶性胶质瘤溶瘤病毒疗法
- 批准号:
10478872 - 财政年份:2018
- 资助金额:
$ 213.9万 - 项目类别:
SPORE for Translational Approaches to Brain Cancer
SPORE 用于脑癌转化方法
- 批准号:
9981687 - 财政年份:2018
- 资助金额:
$ 213.9万 - 项目类别:
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