Feasibility of a Therapeutic Intent Ontology
治疗意图本体的可行性
基本信息
- 批准号:9767858
- 负责人:
- 金额:$ 21.53万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-05-01 至 2021-08-31
- 项目状态:已结题
- 来源:
- 关键词:AnatomyAwarenessCatalogsClinicalComplexComputersControlled VocabularyDataDevelopmentDiseaseDrug usageExpert OpinionFDA approvedGeneticGoalsHealthHumanInformation Resources ManagementInfrastructureInternetLabelMethodsModelingNatureOntologyPainPathologicPatient CarePharmaceutical PreparationsPhysiologicalPrincipal InvestigatorProcessProduct LabelingPublic DomainsReadabilityReproducibilityResourcesSample SizeSamplingSemanticsStructureSymptomsTerminologyTherapeuticTherapeutic UsesVocabularyWorkYangannotation systembasecheminformaticsclinical decision supportdigitalimprovedinformation organizationprecision medicineprogramstoolusabilityweb site
项目摘要
Program Director/Principal Investigator (Last, First, Middle): Nelson, Stuart J.
ABSTRACT
Therapeutic intent can be thought of as the reason for commencing a therapy, not just a disease being
treated, but the context in which the therapy is appropriate. We propose to investigate if it is possible to
represent the therapeutic intent as seen in drug indications in the Structured Product Label approved by the
FDA in a formal, computable manner, using standard controlled vocabularies and a model (an upper level
application ontology). If successful, such a representation could be invaluable in clinical decision support,
precision medicine, and in deepening our understanding of the uses of drugs. We propose studying the
labels of 1000 RxNorm clinical drugs as a sample size, and basing a model on that sample. Then, by
providing a web annotation tool, we would be able to evaluate the utility of the model by using both an
internally developed set or criteria as well as outside use and review.
OMB No. 0925-0001/0002 (Rev. 03/16 Approved Through 10/31/2018) Page 1 Continuation Format Page
项目负责人/主要研究者(最后一名、第一名、中间名):纳尔逊、斯图尔特J。
摘要
治疗意图可以被认为是开始治疗的原因,而不仅仅是一种疾病。
治疗,但治疗的背景是适当的。我们建议调查是否有可能
代表由美国FDA批准的结构化产品标签中药物适应症中的治疗意图。
FDA以正式、可计算的方式,使用标准受控词汇表和模型(上层)
应用本体)。如果成功的话,这种表示在临床决策支持中可能是非常宝贵的,
精准医疗,以及加深我们对药物用途的理解。我们建议研究
1000个RxNorm临床药物标签作为样本量,并基于该样本建立模型。然后通过
提供一个网络注释工具,我们将能够通过使用
内部制定的一套标准以及外部使用和审查。
OMB编号0925-0001/0002(2016年3月批准至2018年10月31日修订版)第1页续格式第页
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
A bottom-up approach to creating an ontology for medication indications.
创建药物适应症本体的自下而上的方法。
- DOI:10.1093/jamia/ocaa331
- 发表时间:2021
- 期刊:
- 影响因子:0
- 作者:Nelson,StuartJ;Flynn,Allen;Tuttle,MarkS
- 通讯作者:Tuttle,MarkS
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STUART James NELSON其他文献
STUART James NELSON的其他文献
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{{ truncateString('STUART James NELSON', 18)}}的其他基金
Improving health data quality by assessing and enhancing semantic integrity
通过评估和增强语义完整性来提高健康数据质量
- 批准号:
10446586 - 财政年份:2022
- 资助金额:
$ 21.53万 - 项目类别:
Improving health data quality by assessing and enhancing semantic integrity
通过评估和增强语义完整性来提高健康数据质量
- 批准号:
10651693 - 财政年份:2022
- 资助金额:
$ 21.53万 - 项目类别:
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