Feasibility of a Therapeutic Intent Ontology
Feasibility of a Therapeutic Intent Ontology
批准号:
9767858
负责人:
STUART James NELSON
金额:
$21.53万
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
已结题
起止时间:
2019-05-01 至 2021-08-31
关键词:
AnatomyAwarenessCatalogsClinicalComplexComputersControlled VocabularyDataDevelopmentDiseaseDrug usageExpert OpinionFDA approvedGeneticGoalsHealthHumanInformation Resources ManagementInfrastructureInternetLabelMethodsModelingNatureOntologyPainPathologicPatient CarePharmaceutical PreparationsPhysiologicalPrincipal InvestigatorProcessProduct LabelingPublic DomainsReadabilityReproducibilityResourcesSample SizeSamplingSemanticsStructureSymptomsTerminologyTherapeuticTherapeutic UsesVocabularyWorkYangannotation systembasecheminformaticsclinical decision supportdigitalimprovedinformation organizationprecision medicineprogramstoolusabilityweb site
中文摘要
项目主管/首席研究员(最后、第一、中):Nelson, Stuart J。
英文摘要
Program Director/Principal Investigator (Last, First, Middle): Nelson, Stuart J.
ABSTRACT
Therapeutic intent can be thought of as the reason for commencing a therapy, not just a disease being
treated, but the context in which the therapy is appropriate. We propose to investigate if it is possible to
represent the therapeutic intent as seen in drug indications in the Structured Product Label approved by the
FDA in a formal, computable manner, using standard controlled vocabularies and a model (an upper level
application ontology). If successful, such a representation could be invaluable in clinical decision support,
precision medicine, and in deepening our understanding of the uses of drugs. We propose studying the
labels of 1000 RxNorm clinical drugs as a sample size, and basing a model on that sample. Then, by
providing a web annotation tool, we would be able to evaluate the utility of the model by using both an
internally developed set or criteria as well as outside use and review.
OMB No. 0925-0001/0002 (Rev. 03/16 Approved Through 10/31/2018) Page 1 Continuation Format Page
期刊论文(1)
专著(0)
科研奖励(0)
会议论文
A bottom-up approach to creating an ontology for medication indications.
创建药物适应症本体的自下而上的方法。
DOI:
10.1093/jamia/ocaa331
发表时间:
2021
期刊:
Journal of the American Medical Informatics Association : JAMIA
影响因子:
--
作者:
[Nelson,StuartJ, Flynn,Allen, Tuttle,MarkS]
通讯作者:
Tuttle,MarkS
Improving health data quality by assessing and enhancing semantic integrity
-
批准号:10446586
-
项目类别:
-
资助金额:$40.0万
-
财政年份:2022
-
负责人:STUART James NELSON
-
依托单位:
Improving health data quality by assessing and enhancing semantic integrity
-
批准号:10651693
-
项目类别:
-
资助金额:$39.27万
-
财政年份:2022
-
负责人:STUART James NELSON
-
依托单位:
Feasibility of a Therapeutic Intent Ontology
-
批准号:9583840
-
项目类别:
-
资助金额:$4.86万
-
财政年份:2018
-
负责人:STUART James NELSON
-
依托单位:
海外基金