California State Food Safety and Security Monitoring Project

FDA FERN合作协议延续计划（U18） 项目概要/摘要 食品和药物实验室分支（FDLB）化学部门的主要重点是 对食品和药品进行监测，以确保公众消费的安全供应。人员 在分析食物基质以检测毒素方面受过培训的人员将继续提供 在发生大规模食品掺假事件时提供样品分析支持。在 此外，参与Gas正在进行的矩阵验证和能力测试 色谱-质谱（GC-MS）、液相色谱-质谱 （LC-MS）和电感耦合等离子体质谱（ICP-MS）将继续 提高工作人员的技能，改善实验室对食品紧急情况的反应。分析 通过这些活动开发的专门知识将为加强现有的 通过将LC-MS毒素筛选扩展到未被很好检测到的极性化合物的方法 目前的技术。建立了检测海洋环境污染物的LC-MS方法 海鲜中的毒素ICP-MS方法将扩大到包括砷的形态， 各种海鲜基质。GC-MS筛查将用于监测补充剂， 无标签和非法成分。另一个研究领域将是调查海洋 通过LC-MS和酶联免疫吸附试验（ELISA）测定毒素。

FDA FERN Cooperative Agreement Continuation Program (U18) Project Summary/Abstract A primary focus of the Food and Drug Laboratory Branch (FDLB) Chemistry Section is the monitoring of food and drug products to ensure a safe supply for public consumption. Personnel trained in the analysis of food matrices for the detection of toxins would continue to provide analytical support with sample analysis in the event of large scale food adulteration events. In addition, participation in ongoing matrix validation and proficiency testing by Gas Chromatography – Mass Spectrometry (GC-MS), Liquid Chromatography – Mass Spectrometry (LC-MS) and Inductively Coupled Plasma Mass Spectrometry (ICP-MS) will continue to advance staff skills and improve the laboratory’s response to food emergencies. The analytical expertise developed by these activities will provide the basis for the enhancement of current methodology by expanding LC-MS toxin screens to polar compounds that are not well detected by current FERN techniques. LC-MS methods will be developed for the detection of marine toxins in seafoods. ICP-MS methods will be expanded to include speciation of arsenic in a variety of seafood matrices. GC-MS screening will be used in surveillance of supplements for unlabeled and illegal ingredients. A further area of study will be the investigation of marine toxins by LC-MS and Enzyme-Linked Immunosorbent Assay (ELISA).