California State Food Safety and Security Monitoring Project

FDA蕨类合作协议延续计划(U18) 项目摘要/摘要 食品和药物化验科化学科的主要工作重点是 对食品和药品进行监测，确保公众消费安全。人员 在分析食物基质以检测毒素方面的培训将继续提供 在发生大规模食品掺假事件时，为样品分析提供分析支持。在……里面 此外，参与持续的矩阵验证和由Gas进行的能力测试 气-质联用(GC-MS)、液-质联用(LC-MS) (LC-MS)和电感耦合等离子体质谱(ICP-MS)将继续 提高员工技能，提高实验室对食品紧急情况的反应能力。分析性的 这些活动所产生的专门知识将为加强现有的 将LC-MS毒素筛选扩展到未被很好检测的极性化合物的方法学 通过目前的蕨类技术。将开发LC-MS方法来检测海洋环境中的 海鲜中的毒素。电感耦合等离子体质谱方法将扩展到包括砷的形态 各种海鲜基质。GC-MS筛查将用于补充剂的监测 未贴标签的非法成分。另一个研究领域将是对海洋的调查 毒素的LC-MS和酶联免疫吸附分析(ELISA)。

FDA FERN Cooperative Agreement Continuation Program (U18) Project Summary/Abstract A primary focus of the Food and Drug Laboratory Branch (FDLB) Chemistry Section is the monitoring of food and drug products to ensure a safe supply for public consumption. Personnel trained in the analysis of food matrices for the detection of toxins would continue to provide analytical support with sample analysis in the event of large scale food adulteration events. In addition, participation in ongoing matrix validation and proficiency testing by Gas Chromatography – Mass Spectrometry (GC-MS), Liquid Chromatography – Mass Spectrometry (LC-MS) and Inductively Coupled Plasma Mass Spectrometry (ICP-MS) will continue to advance staff skills and improve the laboratory’s response to food emergencies. The analytical expertise developed by these activities will provide the basis for the enhancement of current methodology by expanding LC-MS toxin screens to polar compounds that are not well detected by current FERN techniques. LC-MS methods will be developed for the detection of marine toxins in seafoods. ICP-MS methods will be expanded to include speciation of arsenic in a variety of seafood matrices. GC-MS screening will be used in surveillance of supplements for unlabeled and illegal ingredients. A further area of study will be the investigation of marine toxins by LC-MS and Enzyme-Linked Immunosorbent Assay (ELISA).