Dietary Supplements and Inflammation Phase-2

摘要： 科布雷大学膳食补充剂和炎症(CDSI)第二阶段的总体目标 南卡罗来纳州(南卡罗来纳州)的目标是继续在第一阶段成功的基础上继续推进研究 通过促进多学科，特别是在膳食补充剂和炎症领域的基础设施 初级研究人员所从事的研究，以便他们在获得NIH R01拨款和 类似类型的校外资助，以继续他们的研究。总体目标是调查植物学如何 可以减轻炎症，并可用于预防和/或治疗炎症性疾病。CDSI将测试 认为植物或其成分通过表观遗传调节来调节炎症的最重要的假说 免疫细胞的功能。在第一阶段，我们取得了显著的进展，所有的成功过渡 我们的初级教员变成了外部资助的调查员。此外，我们还成功地确保了美国国立卫生研究院 补充和替代医学(CAM)中心(P01)，用于炎症的表观遗传调节 这些“毕业”的教师正在领导这些项目，从而为CDSI的可持续性铺平了道路。因此， CDSI将补充CAM研究，并在南加州大学炎症研究领域创造独特的利基市场。这个 Cobre第二阶段的主要目标是建立多学科研究，以确定表观遗传学 植物性药物调节炎症以便它们或其类似物可用于 预防和/或治疗炎症性疾病。美国人口每年在CAM上的支出约为339亿美元，其中 约200亿美元用于膳食补充剂。越来越清楚的是，炎症在疾病中起着关键作用 不仅自身免疫性疾病的发病机制，还包括广泛的临床疾病 心血管疾病、神经退行性疾病、肥胖、衰老和癌症。因此，理解 植物药物或其成分对炎症的作用模式，可能导致新的治疗模式 具有广泛的临床意义。CDSI的目标将通过促进多学科来实现 4名初级教员通过高度结构化的指导，在炎症性疾病领域进行研究 分别由科布雷第一阶段的一名资深教员和一名新近毕业的教员主持。初级教员 将能够使用最先进的研究核心设施，包括流式细胞术、显微镜和成像 核心和生物分析核心，以帮助表观遗传学研究。该计划将由外部顾问进行评估 由国家公认的科学家组成的委员会。此外，通过机构支持，5个新的 南加州大学将招聘和指导终身教职的初级教师，以支持和推进炎症研究。 CDSI的长期目标将是建立一个自给自足、得到国家和国际认可的 多学科膳食补充剂和炎症研究中心，通过促进创新，教职员工 创业、合作研究项目，如PPG和机构培训赠款，以及 临床/转化性研究。

Abstract: The overall objective of the COBRE Phase-2 for Dietary Supplements and Inflammation (CDSI) at the University of South Carolina (USC) is to continue to build on the success of Phase-1 and advance the research infrastructure specifically in the area of dietary supplements and inflammation by promoting multi-disciplinary research pursued by junior investigators so that they become highly competitive in obtaining NIH R01 grants and similar type of extramural funding to pursue their research. The overall objective is to investigate how botanicals can attenuate inflammation and be used to prevent and/or treat inflammatory diseases. The CDSI will test the overarching hypothesis that botanicals or their constituents regulate inflammation through epigenetic regulation of immune cell functions. In Phase-1, we have made outstanding progress in the successful transition of all of our junior faculty into extramurally-funded investigators. Additionally, we were successful in securing NIH Complementary and Alternative Medicine (CAM) Center (P01) for Epigenetic Regulation of Inflammation, in which ‘graduated’ faculty are leading the projects, thereby paving the path towards sustainability of CDSI. Thus, the CDSI will complement the CAM Research and create a unique niche at USC in inflammation research. The main goal of COBRE Phase-2 is to establish multi-disciplinary research that will identify the epigenetic mechanisms through which botanicals modulate inflammation so that they or their analogs can be used to prevent and/or treat inflammatory diseases. The US population spends ~$33.9 billion/year on CAM, of which ~$20 billion is on dietary supplements. It is becoming increasingly clear that inflammation plays a critical role in the pathogenesis of not only autoimmune diseases but also a wide range of clinical disorders including cardiovascular diseases, neurodegenerative disorders, obesity, aging and cancer. Thus, understanding the mode of action of botanicals or their constituents on inflammation, could lead to novel treatment modalities with far ranging clinical implications. The CDSI goal will be accomplished through promotion of multi-disciplinary research pursued by 4 junior faculty in the area of inflammatory diseases, through highly structured mentoring of each by a senior faculty and a recently graduated faculty member of the COBRE Phase-1. The junior faculty will have access to state-of-the-art research core facilities that include Flow Cytometry, Microscopy and Imaging Core, and Bioanalytical Core, to aid epigenetic studies. The program will be evaluated by an External Advisory Committees consisting of nationally recognized scientists. Additionally, through institutional support, 5 new tenure-track junior faculty will be recruited and mentored at USC to bolster and advance inflammation research. The long term objective of the CDSI would be to build a self-sustaining, nationally and internationally recognized multi-disciplinary Center for dietary supplements and inflammation research, by promoting innovation, faculty entrepreneurship, collaborative research projects such as PPGs and Institutional training grants, and clinical/translational research.