Improved temperature and quantitative magnetic resonance imaging specific for hyperthermia treatment monitoring and assessment

改进的温度和定量磁共振成像专门用于热疗监测和评估

• 批准号: 9893833
• 负责人: Lorne Wyatt Hofstetter
• 金额: $ 4.79万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-02 至 2023-04-01
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9893833
• 关键词: 3-Dimensional; Adipose tissue; Adoption; Algorithms; Anatomy; Blood; Breast; Breast Cancer therapy; Cervix carcinoma; Clinical; Computer software; Development; Ensure; Environment; Fatty acid glycerol esters; Fiber Optics; Focused Ultrasound; Glioblastoma; Goals; Gold; Head and Neck Cancer; Health; Heating; High temperature of physical object; Human; Human Volunteers; Hyperthermia; Image; Imaging Device; Imaging Techniques; Implant; Induced Hyperthermia; Infection; Institution; Life; Location; Magnetic Resonance; Magnetic Resonance Imaging; Magnetism; Malignant Neoplasms; Maps; Measurement; Measures; Methods; Modeling; Monitor; Morbidity - disease rate; Motion; Oryctolagus cuniculus; Oxygen; Patients; Perfusion; Phase; Phase III Clinical Trials; Positive Lymph Node; Predisposition; Procedures; Protocols documentation; Public Health; Radiation therapy; Radiosensitization; Reading; Recurrence; Research; Resources; Sampling; Savings; Soft tissue sarcoma; Structure; System; Techniques; Temperature; Testing; Therapeutic; Thermometry; Tissues; Treatment Efficacy; Treatment Protocols; Tumor Oxygenation; Tumor Volume; advanced breast cancer; aqueous; breast imaging; cancer therapy; chemotherapy; contrast enhanced; contrast imaging; design; effective therapy; fighting; hyperthermia treatment; image guided; imaging modality; improved; in vivo; interstitial; malignant breast neoplasm; melanoma; new technology; non-invasive imaging; non-invasive monitor; pre-clinical; prognostic; reconstruction; response; tissue oxygenation; treatment duration; tumor

Project Summary/Abstract This research is a vital part of making targeted-hyperthermia treatments for cancer therapy clinically viable. For treatment monitoring and efficacy assessment, interstitial temperature probe readings are the current standard metric. However, temperature probes are invasive, prone to infection, and provide a limited sampling of the tumor volume. Magnetic resonance temperature imaging (MRTI) has the potential to alleviate these shortcomings: (1) 3D volumetric temperature measurements can provide coverage of both the tumor volume and surrounding critical structures; (2) measurement is completely noninvasive—patient discomfort and complications due to interstitial temperature probes are eliminated. While MRTI has achieved widespread use for short-duration high-temperature ablative thermal therapies, treatment-monitoring requirements for hyperthermia are significantly different. Robustly monitoring a small temperature rise (several degrees Celsius) over a long hyperthermia treatment period (60-90 minutes) is not feasible in many anatomic locations with current techniques. Patient motion, field drift, treatment induced susceptibility change, and other systemic errors can confound MRTI. A key aim of this proposal is to develop a stable and effective MRTI technique for hyperthermia treatment monitoring in the breast. Temperature is not the only plausible metric for predicting tumor response to hyperthermia. Increased tumor oxygenation and perfusion are known to sensitize tumors to radiotherapy and chemotherapy. This proposal will develop and test the use of quantitative magnetic resonance imaging (MRI) to assess hyperthermia-induced changes in tumor oxygenation and perfusion. The overarching goal of this proposal is to accelerate the adoption of mild-hyperthermia for cancer therapy by providing non-invasive multi-parametric MRI techniques for treatment monitoring and efficacy assessment. The project consists of three specific aims to achieve this goal: 1) Develop stable, hyperthermia dedicated method for 3D temperature measurement in tissues containing aqueous and adipose tissues; 2) Develop quantitative MRI techniques to measure hyperthermia induced changes in tumor oxygenation and perfusion; 3) Evaluate developed thermometry and quantitative MRI techniques during a hyperthermia heating protocol in a preclinical tumor model. RELEVANCE TO PUBLIC HEALTH: Phase III clinical trials have demonstrated that hyperthermia when combined with radiotherapy or chemotherapy leads improves local control and/or survival for a number of cancers. Technical developments proposed in this application will accelerate the adoption of these cancer- fighting therapies by providing non-invasive techniques that are better tolerated by patients and provide superior prognostic measures and treatment monitoring capabilities. Software and techniques developed under this project will be freely shared on Github to help enable and accelerate the adoption of efficacious MRI- guided hyperthermia treatments.

项目总结/摘要 这项研究是使癌症治疗的靶向热疗治疗在临床上可行的重要组成部分。为 治疗监测和疗效评估，组织间温度探头读数是当前标准 公制然而，温度探针是侵入性的，易于感染，并且提供了对血液的有限采样。 肿瘤体积磁共振温度成像（MRTI）有可能减轻这些 缺点：（1）3D体积温度测量可以提供肿瘤体积 和周围的关键结构;（2）测量是完全非侵入性的-患者不适， 消除了由于间隙式温度探针引起的并发症。虽然MRTI已经广泛使用， 对于短时间高温消融热疗法， 热疗是显著不同的。可靠地监测微小的温度上升（几摄氏度） 在长的热疗治疗期（60-90分钟）内， 目前的技术。患者运动、场漂移、治疗引起的磁化率变化和其他系统性变化 错误可以混淆MRTI。该提案的主要目的是开发一种稳定有效的MRTI技术， 乳房中的高温治疗监测。温度并不是唯一合理的预测指标 肿瘤对高温的反应已知增加的肿瘤氧合和灌注使肿瘤对以下敏感： 放疗和化疗。这项建议将开发和测试使用定量磁 使用核磁共振成像（MRI）来评估高血压诱导的肿瘤氧合和灌注的变化。的 该提案的首要目标是通过以下方式加速采用轻度高温治疗癌症 为治疗监测和疗效评估提供无创多参数MRI技术。的 该项目包括三个具体目标来实现这一目标：1）开发稳定的，热疗专用方法 用于包含水组织和脂肪组织的组织中的3D温度测量; 2）开发定量 MRI技术测量高温诱导的肿瘤氧合和灌注的变化; 3）评估 在临床前的高温加热方案中开发了测温和定量MRI技术， 肿瘤模型 与公共卫生的相关性：III期临床试验表明， 与放疗或化疗导线相结合可改善许多患者的局部控制和/或生存 癌的本申请中提出的技术发展将加速采用这些癌症- 通过提供患者更好耐受的非侵入性技术来对抗治疗， 上级预后指标和治疗监测能力。在此框架下开发的软件和技术 该项目将在Github上免费分享，以帮助实现和加速采用有效的MRI- 引导性热疗