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Improved temperature and quantitative magnetic resonance imaging specific for hyperthermia treatment monitoring and assessment

改进的温度和定量磁共振成像专门用于热疗监测和评估

基本信息

批准号：
10380800
负责人：
Lorne Wyatt Hofstetter
金额：
$ 5.27万
依托单位：
UNIVERSITY OF UTAH
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-04-02 至 2024-04-01
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10380800
关键词：
3-Dimensional Acceleration Adipose tissue Adoption Algorithms Anatomy Blood Breast Breast Cancer therapy Cervix carcinoma Chemotherapy and/or radiation Clinical Computer software Dedications Development Ensure Environment Fatty acid glycerol esters Fiber Optics Focused Ultrasound Glioblastoma Goals Head and Neck Cancer Health Heating High temperature of physical object Human Human Volunteers Hyperthermia Image Imaging Device Imaging Techniques Implant Induced Hyperthermia Infection Institution Life Location Magnetic Resonance Magnetic Resonance Imaging Magnetism Malignant Neoplasms Maps Measurement Measures Methods Modeling Monitor Morbidity - disease rate Motion Oryctolagus cuniculus Oxygen Patients Perfusion Phase III Clinical Trials Positive Lymph Node Predisposition Procedures Protocols documentation Public Health Radiation therapy Radiosensitization Recurrence Research Resources Sampling Soft tissue sarcoma Structure System Techniques Temperature Testing Therapeutic Thermometry Tissues Treatment Efficacy Treatment Protocols Tumor Oxygenation Tumor Volume advanced breast cancer aqueous breast imaging cancer therapy chemotherapy contrast enhanced design effective therapy efficacy evaluation fighting hyperthermia treatment imaging modality improved in vivo interstitial malignant breast neoplasm melanoma new technology non-invasive imaging non-invasive monitor optical fiber pre-clinical prognostic reconstruction response tissue oxygenation tool treatment duration tumor

项目摘要

Project Summary/Abstract This research is a vital part of making targeted-hyperthermia treatments for cancer therapy clinically viable. For treatment monitoring and efficacy assessment, interstitial temperature probe readings are the current standard metric. However, temperature probes are invasive, prone to infection, and provide a limited sampling of the tumor volume. Magnetic resonance temperature imaging (MRTI) has the potential to alleviate these shortcomings: (1) 3D volumetric temperature measurements can provide coverage of both the tumor volume and surrounding critical structures; (2) measurement is completely noninvasive—patient discomfort and complications due to interstitial temperature probes are eliminated. While MRTI has achieved widespread use for short-duration high-temperature ablative thermal therapies, treatment-monitoring requirements for hyperthermia are significantly different. Robustly monitoring a small temperature rise (several degrees Celsius) over a long hyperthermia treatment period (60-90 minutes) is not feasible in many anatomic locations with current techniques. Patient motion, field drift, treatment induced susceptibility change, and other systemic errors can confound MRTI. A key aim of this proposal is to develop a stable and effective MRTI technique for hyperthermia treatment monitoring in the breast. Temperature is not the only plausible metric for predicting tumor response to hyperthermia. Increased tumor oxygenation and perfusion are known to sensitize tumors to radiotherapy and chemotherapy. This proposal will develop and test the use of quantitative magnetic resonance imaging (MRI) to assess hyperthermia-induced changes in tumor oxygenation and perfusion. The overarching goal of this proposal is to accelerate the adoption of mild-hyperthermia for cancer therapy by providing non-invasive multi-parametric MRI techniques for treatment monitoring and efficacy assessment. The project consists of three specific aims to achieve this goal: 1) Develop stable, hyperthermia dedicated method for 3D temperature measurement in tissues containing aqueous and adipose tissues; 2) Develop quantitative MRI techniques to measure hyperthermia induced changes in tumor oxygenation and perfusion; 3) Evaluate developed thermometry and quantitative MRI techniques during a hyperthermia heating protocol in a preclinical tumor model. RELEVANCE TO PUBLIC HEALTH: Phase III clinical trials have demonstrated that hyperthermia when combined with radiotherapy or chemotherapy leads improves local control and/or survival for a number of cancers. Technical developments proposed in this application will accelerate the adoption of these cancer- fighting therapies by providing non-invasive techniques that are better tolerated by patients and provide superior prognostic measures and treatment monitoring capabilities. Software and techniques developed under this project will be freely shared on Github to help enable and accelerate the adoption of efficacious MRI- guided hyperthermia treatments.

项目摘要/摘要这项研究是使癌症治疗的靶向热疗在临床上可行的重要组成部分。为治疗监测和疗效评估，间质温度探头读数是目前的标准公制。然而，温度探头是侵入性的，容易感染，并提供有限的样本肿瘤体积。磁共振温度成像(MRTI)有可能缓解这些缺点：(1)3D体积温度测量可以提供肿瘤体积的覆盖和周围关键结构；(2)测量是完全非侵入性的-患者不适和消除了因间质温度探头引起的并发症。虽然MRTI已经实现了广泛的使用用于短期高温烧蚀热疗的治疗监测要求体温过高有显著不同。强劲地监测着一个小的温度上升(几摄氏度) 过长的热疗周期(60-90分钟)在许多解剖位置是不可行的，最新的技术。患者运动、磁场漂移、治疗引起的敏感性改变以及其他全身性改变错误可能会让MRTI感到困惑。这项建议的一个关键目标是开发一种稳定有效的MRTI技术乳房热疗监测。温度并不是唯一可信的预测指标肿瘤对高温的反应。众所周知，增加肿瘤的氧合和灌注会使肿瘤对放射治疗和化疗。这项提议将开发和测试定量磁力的使用磁共振成像(MRI)评估热疗引起的肿瘤氧合和血流灌注的变化。这个这项提议的总体目标是通过以下方式加快采用亚高温治疗癌症提供用于治疗监测和疗效评估的非侵入性多参数磁共振技术。这个该项目由三个具体目标组成，以实现这一目标：1)开发稳定的、专用的热疗方法用于含房水和脂肪组织的3D温度测量；2)开发定量测量高温引起的肿瘤氧合和血流灌注变化的MRI技术；3)评估在临床前的热疗加热方案中开发体温测量和定量MRI技术肿瘤模型。与公共健康相关：第三阶段临床试验表明，当体温过高时结合放疗或化疗导联可改善局部控制和/或多个癌症。本申请中提出的技术发展将加速这些癌症的采用- 通过提供患者更好地耐受的非侵入性技术来对抗治疗，并提供卓越的预后措施和治疗监测能力。开发的软件和技术该项目将在Github上免费共享，以帮助支持和加速采用有效的MRI- 引导热疗。