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The Transporter Classification Database (TCDB)

运输者分类数据库 (TCDB)

基本信息

批准号：
9895808
负责人：
MILTON H. SAIER
金额：
$ 31.5万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-04-01 至 2022-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9895808
关键词：
Activator Appliances Adopted Affect Alternative Splicing Antimicrobial Resistance Antineoplastic Agents Biochemical Biochemistry Biological Phenomena Biology Biotechnology Carrier Proteins Cells Chemicals Classification Collaborations Communities Complement Computer software Data Database Management Systems Databases Development Ecosystem Ensure Eukaryota Family Funding Genetic Diseases Genome Genomics Goals Grant Health Homeostasis Human Genetics Individual Information Resources International Investigation Island Knowledge Laboratories Life Ligands Literature Machine Learning Medical Medicine Membrane Proteins Metabolic Metabolism Methods Modeling Modernization Molecular Molecular Biology Multi-Drug Resistance Ontology Organelles Pathogenesis Pathologic Pharmaceutical Preparations Phenotype Physiological Play Post-Translational Protein Processing Production Protein Isoforms Proteins Pump RNA Splicing Research Research Personnel Role Scientist Stimulus Structure System Systems Biology Tertiary Protein Structure Time Tissues Training Transmembrane Transport Update Variant Vertebral column Work Xenobiotics base data pipeline drug development improved inhibitor/antagonist insight member metagenome novel pathogen personalized medicine protein transport screening text searching transmission process tumor whole genome willingness

项目摘要

ABSTRACT Transporters catalyze entry and exit of molecules into and out of cells and organelles. They achieve cellular homeostasis, are responsible for multidrug resistance in pathogens and tumors, and, when defective, cause dozens of important human genetic diseases. Our laboratory maintains, updates and improves the Transporter Classification Database, TCDB, which houses the Transporter Classification (TC) system, adopted officially by the International Union of Biochemistry and Molecular Biology (IUBMB). TCDB is the internationally acclaimed, carefully annotated, universal standard for classifying and providing information about transporters and transport-related proteins in all major domains of life. It presents sequence, biochemical, physiological, pathological, structural and evolutionary data about these proteins and the transport systems they comprise. It uses a successful system of classification based on transporter class, subclass, family, subfamily, individual transport system and constituent proteins. It also includes a superfamily hyperlink. In this competitive renewal of GM0077402, we propose to continue to expand, update, and semi-automate TCDB. Our specific aims are to (1) upgrade TCDB by characterizing and categorizing protein domains and their topologies, motifs, repeat units, functional interactions, alternative splicing and post-translational modifications, (2) expand TCDB by implementing novel pipelines for data entry that will increase the coverage of transport diversity in TCDB while describing more effectively the complexity of multicomponent transport systems, (3) enter into TCDB transporter modulators such as activators, inhibitors, drugs and xenobiotics as well as internal and external conditions that influence transporter activities, while generating an ontology to describe the effects of chemical modulators that will complement our substrate ontology, (4) incorporate into TCDB synthetic pores/channels (TC subclass 1.D), and carriers (TC subclass 2.B), (5) introduce into TCDB connections between transport and metabolism and (6) expand our plans for long-term TCDB sustainability.

摘要