Biostatistics and Bioinformatics Shared Facility

临床研究小组 生物统计和生物信息学共享设施(BBsf) 摘要 生物统计和生物信息学共享设施(BBSF)的主要目标是提供集中的 为UAB的研究项目提供研究设计、数据分析专长和协作研究支持 综合癌症中心(UAB-CCC)。为了实现这一目标，BBsf有以下具体目标：1) 协调和管理中心的统计和生物信息学活动，确保调查人员拥有 随时获得研究设计和分析咨询及支持；2)为CCC项目提供数据分析 使用现代统计方法；3)为研究设计和研究提供统计咨询 提案制定，包括试点项目；4)参与中心的教学和培训活动；5) 提供高质量、集中化的数据管理服务；以及6)为 实验设计和分析，将增强BBsf在提供 协作性研究支持。BBsf继续响应日益增长的需求 在机械和功能研究中使用“组学”技术的多维数据分析，包括 CCC微生物组倡议，并与其他共享设施密切合作，在这些领域提供支持。 BBsf还在CCC的外展工作中发挥积极作用，并提供研究设计方面的培训 以及对NCI支持的UAB、莫尔豪斯医学院和 塔斯基吉大学伙伴关系。BBSF由一支由教职员工和支持人员组成的团队组成， 主要来自医学部预防医学司，并呼吁 在需要的基础上提供咨询资源。它为CCC调查人员提供了方便地访问成熟的 以及时和具有成本效益的方式提供全面的生物统计和生物信息学支持。这个 该设施的成功是显而易见的，因为与癌症有关的出版物和赠款的数量都很高 BBsf在研究设计和统计分析方面提供关键支持。

CLINICAL RESEARCH GROUP BIOSTATISTICS AND BIOINFORMATICS SHARED FACILITY (BBSF) ABSTRACT The primary objective of the Biostatistics and Bioinformatics Shared Facility (BBSF) is to provide centralized study design, data analytic expertise, and collaborative research support for the research projects of the UAB Comprehensive Cancer Center (UAB-CCC). To accomplish this, the BBSF has the following specific aims: 1) coordinate and manage statistical and bioinformatics activities in the CCC, ensuring that investigators have ready access to study design and analytic consultation and support; 2) provide data analysis for CCC projects using contemporary statistical methodologies; 3) provide statistical consultation on study design and research proposal development, including pilot projects; 4) participate in teaching and training activities of the CCC; 5) provide high-quality, centralized data management services; and 6) develop methodologies for novel experimental designs and analyses that will enhance the BBSF's technical capabilities in providing collaborative research support. The BBSF continues to respond to the increasing requirement for multidimensional data analyses in mechanistic and functional studies using “-omics” technologies, including the CCC Microbiome initiative, and works closely with the other Shared Facilities to provide support in these areas. The BBSF also plays an active role in the outreach efforts of the CCC and provides training in research design as well as ongoing support to investigators in the NCI-supported UAB, Morehouse School of Medicine and Tuskegee University partnership. The BBSF is composed of a team of faculty members and support staff, primarily from the Division of Preventive Medicine in the Department of Medicine, and calls on additional consultation resources on an as-needed basis. It provides CCC investigators easy access to well-established and comprehensive biostatistical and bioinformatics support in a timely and cost-effective manner. The success of the facility is evident through the high volume of both cancer-related publications and grants for which the BBSF provides key support in research design and statistical analyses.