An Examination of the Effects of Synthetic Opioids on Injecting Heroin Trajectories, Practices, and Risk Behaviors

合成阿片类药物对注射海洛因轨迹、实践和危险行为的影响的研究

• 批准号: 9896646
• 负责人: Tasha Perdue
• 金额: $ 5.4万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9896646
• 关键词: Address; Age; Behavior; Calendar; California; Characteristics; Communicable Diseases; Communities; Data; Development; Disease Outbreaks; Drug Combinations; Drug usage; Drug user; Environment; Environmental Risk Factor; Epidemiology; Exposure to; Faculty; Fentanyl; Foundations; Frequencies; Gap Junctions; Goals; Harm Reduction; Health; Heroin; Heroin Users; Hot Spot; Indigenous; Individual; Injections; Interdisciplinary Study; Intervention; Interview; Knowledge; Methodology; Methods; Mind; Modeling; Naloxone; National Institute of Drug Abuse; Needle Sharing; Ohio; Outcome; Overdose; Pathway interactions; Pattern; Perception; Pharmaceutical Preparations; Population; Prevalence; Prevention; Principal Investigator; Qualitative Research; Recording of previous events; Reporting; Research; Research Design; Research Personnel; Respondent; Rest; Risk; Risk Behaviors; Risk Factors; Risk Reduction; Sampling; Site; Social Environment; Strategic Planning; Structure; Techniques; Testing; Universities; addiction; analog; contextual factors; disease transmission; doctoral student; drug market; experience; geographic difference; heroin use; high risk; implementation science; improved; innovation; insight; life history; non-opioid analgesic; opioid epidemic; opioid mortality; opioid user; overdose prevention; overdose risk; preference; protective behavior; recruit; resilience; response; social; social situation; synthetic opioid; trend

Project Summary Identifying context specific risks for individuals who inject heroin is central to overdose prevention and the control of infectious diseases, given that the current opioid crisis is now characterized by a heroin supply contaminated with synthetic opioids. While epidemiological patterns of risk are known from previous studies of heroin use, what is not clear is how individual behaviors, strategies and local social and situational factors in the current synthetic opioid/non-pharmaceutical fentanyl (NPF) crisis are promoting risk factors and/or self-protective behaviors in distinct emerging fentanyl “hot spots”, such as Ohio. Informed by the Drug, Set, and Setting Framework with concepts from the Symbiotic Model of Risk Reduction, this application will determine how social and environmental determinants influence the relationship between heroin/NPF use trajectories, adverse health outcomes, and risk or self-protective behaviors among individuals who inject heroin/NPF in Dayton, Ohio. Using adaptive respondent driven sampling, 60 individuals reporting injecting heroin/NPF in the past month will be recruited for qualitative life history interviews. The specific aims of the proposed study are: AIM 1: Provide an in- depth qualitative description of how a rapidly changing heroin/NPF market (type/quality, availability) has impacted injecting heroin/NPF use trajectories (initiation, drug switching, concurrent use) and adverse health related drug risk behavior (overdoses, syringe sharing) in Dayton, Ohio; AIM 2: Examine individual-level perceptions, preferences, and perceived effects regarding synthetic opioids, related strategies for the identification of heroin adulterated with synthetic opioids, and current risk reduction practices among individuals who inject heroin/NPF in Dayton, Ohio; AIM 3: Characterize qualitatively the influence of cultural and social context on strategies, practices, and tactics for safer or riskier behaviors among individuals who inject heroin/NPF in Dayton, Ohio. Proposed Principal Investigator, Tasha Perdue, is a PhD student leading an interdisciplinary research team between faculty from USC and the Wright State University Center for Interventions, Treatment, and Addictions Research. This highly productive collaborative interdisciplinary team is well suited to accomplish the research goals. This research will have an important positive impact by identifying pathways of individuals who are at the highest risk for developing harmful heroin/NPF use trajectories within this distinct social context given the changes in availability of NPF and its analogues. In doing this, the project will lay the foundation for the development and implementation of culturally appropriate targeted prevention and treatment interventions that will reduce risk behaviors of heroin/NPF users that have gone underrepresented in existing research.

项目摘要 为注入海洛因的个人确定环境特定风险是预防过量和控制的核心 鉴于当前的阿片类药物危机现在是海洛因供应污染的特征 与合成阿片类药物。虽然先前关于海洛因使用的研究知道流行病学的风险模式，但什么 目前的综合中的个人行为，策略以及当地的社会和情境因素如何不清楚 阿片类药物/非药物芬太尼（NPF）危机正在促进危险因素和/或自我保护行为 独特的新兴芬太尼“热点”，例如俄亥俄州。通过药物告知，设置和设置框架 来自降低风险的共生模型的概念，该应用将决定社会和 环境决定者会影响海洛因/NPF使用轨迹，不良健康之间的关系 在俄亥俄州代顿注射海洛因/NPF的个人的结果以及风险或自我保护行为。使用 自适应受访者驾驶抽样，过去一个月报告海洛因/NPF的60个人将是 招募定性人生史访谈。拟议研究的具体目的是：目标1：提供一个内部 深度描述海洛因/NPF市场如何变化（类型/质量，可用性） 受影响的注射海洛因/NPF使用轨迹（启动，药物转换，并发使用）和不良健康 俄亥俄州代顿的相关药物风险行为（过量，注射器共享）；目标2：检查个人级别 对合成阿片类药物的感知，偏好和感知的影响，相关策略 用合成阿片类药物掺假的海洛因的鉴定以及个人当前的降低风险实践 谁在俄亥俄州代顿注入海洛因/NPF；目标3：定性地表征文化和社会的影响 关于注射的个人的策略，实践和策略和策略的背景 海洛因/NPF在俄亥俄州代顿。拟议的首席研究员塔莎·珀杜（Tasha Perdue）是一名博士生领导 南加州大学教师与赖特州立大学中心之间的跨学科研究团队 干预，治疗和成瘾研究。这个高产的协作跨学科团队是 非常适合实现研究目标。这项研究将通过确定 在此内开发有害海洛因/NPF使用轨迹最高风险的个人的途径 鉴于NPF及其类似物的可用性变化，不同的社会环境。为此，该项目将 为开发和实施具有文化适当的针对性预防和实施奠定基础 治疗干预措施将减少代表不足的海洛因/NPF用户的风险行为 现有研究。