An Examination of the Effects of Synthetic Opioids on Injecting Heroin Trajectories, Practices, and Risk Behaviors

合成阿片类药物对注射海洛因轨迹、实践和危险行为的影响的研究

• 批准号: 9896646
• 负责人: Tasha Perdue
• 金额: $ 5.4万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9896646
• 关键词: Address; Age; Behavior; Calendar; California; Characteristics; Communicable Diseases; Communities; Data; Development; Disease Outbreaks; Drug Combinations; Drug usage; Drug user; Environment; Environmental Risk Factor; Epidemiology; Exposure to; Faculty; Fentanyl; Foundations; Frequencies; Gap Junctions; Goals; Harm Reduction; Health; Heroin; Heroin Users; Hot Spot; Indigenous; Individual; Injections; Interdisciplinary Study; Intervention; Interview; Knowledge; Methodology; Methods; Mind; Modeling; Naloxone; National Institute of Drug Abuse; Needle Sharing; Ohio; Outcome; Overdose; Pathway interactions; Pattern; Perception; Pharmaceutical Preparations; Population; Prevalence; Prevention; Principal Investigator; Qualitative Research; Recording of previous events; Reporting; Research; Research Design; Research Personnel; Respondent; Rest; Risk; Risk Behaviors; Risk Factors; Risk Reduction; Sampling; Site; Social Environment; Strategic Planning; Structure; Techniques; Testing; Universities; addiction; analog; contextual factors; disease transmission; doctoral student; drug market; experience; geographic difference; heroin use; high risk; implementation science; improved; innovation; insight; life history; non-opioid analgesic; opioid epidemic; opioid mortality; opioid user; overdose prevention; overdose risk; preference; protective behavior; recruit; resilience; response; social; social situation; synthetic opioid; trend

Project Summary Identifying context specific risks for individuals who inject heroin is central to overdose prevention and the control of infectious diseases, given that the current opioid crisis is now characterized by a heroin supply contaminated with synthetic opioids. While epidemiological patterns of risk are known from previous studies of heroin use, what is not clear is how individual behaviors, strategies and local social and situational factors in the current synthetic opioid/non-pharmaceutical fentanyl (NPF) crisis are promoting risk factors and/or self-protective behaviors in distinct emerging fentanyl “hot spots”, such as Ohio. Informed by the Drug, Set, and Setting Framework with concepts from the Symbiotic Model of Risk Reduction, this application will determine how social and environmental determinants influence the relationship between heroin/NPF use trajectories, adverse health outcomes, and risk or self-protective behaviors among individuals who inject heroin/NPF in Dayton, Ohio. Using adaptive respondent driven sampling, 60 individuals reporting injecting heroin/NPF in the past month will be recruited for qualitative life history interviews. The specific aims of the proposed study are: AIM 1: Provide an in- depth qualitative description of how a rapidly changing heroin/NPF market (type/quality, availability) has impacted injecting heroin/NPF use trajectories (initiation, drug switching, concurrent use) and adverse health related drug risk behavior (overdoses, syringe sharing) in Dayton, Ohio; AIM 2: Examine individual-level perceptions, preferences, and perceived effects regarding synthetic opioids, related strategies for the identification of heroin adulterated with synthetic opioids, and current risk reduction practices among individuals who inject heroin/NPF in Dayton, Ohio; AIM 3: Characterize qualitatively the influence of cultural and social context on strategies, practices, and tactics for safer or riskier behaviors among individuals who inject heroin/NPF in Dayton, Ohio. Proposed Principal Investigator, Tasha Perdue, is a PhD student leading an interdisciplinary research team between faculty from USC and the Wright State University Center for Interventions, Treatment, and Addictions Research. This highly productive collaborative interdisciplinary team is well suited to accomplish the research goals. This research will have an important positive impact by identifying pathways of individuals who are at the highest risk for developing harmful heroin/NPF use trajectories within this distinct social context given the changes in availability of NPF and its analogues. In doing this, the project will lay the foundation for the development and implementation of culturally appropriate targeted prevention and treatment interventions that will reduce risk behaviors of heroin/NPF users that have gone underrepresented in existing research.

项目摘要 确定注射海洛因个人的特定背景风险是预防和控制过量服药的核心 传染性疾病，因为目前的阿片类药物危机的特点是海洛因供应受到污染 使用合成阿片类药物。虽然风险的流行病学模式是从以前的海洛因使用研究中得知的，但什么 目前尚不清楚的是，个体行为、策略以及当地的社会和情境因素是如何综合的 阿片类药物/非药物芬太尼(NPF)危象正在促进危险因素和/或自我保护行为 明显新兴的芬太尼“热点”，如俄亥俄州。由药物、SET和设置框架提供信息 降低风险的共生模型中的概念，这一应用程序将决定如何社会和 环境决定因素影响海洛因/NPF使用轨迹与不良健康之间的关系 结果，以及在俄亥俄州代顿市注射海洛因/NPF的个人的风险或自我保护行为。vbl.使用 适应性受访者驱动抽样，过去一个月报告注射海洛因/NPF的60人将被 被招募参加定性的生活史访谈。拟议研究的具体目标是：目标1：提供一个-- 对快速变化的海洛因/NPF市场(类型/质量、供应情况)的深度定性描述 受影响的注射海洛因/NPF使用轨迹(开始、药物更换、同时使用)和不良健康 俄亥俄州代顿市的相关毒品风险行为(过量、共用注射器)；目标2：检查个人水平 关于合成阿片类药物的感知、偏好和感知效果，相关策略 掺入合成阿片类药物的海洛因的鉴定和个人目前的降低风险做法 世卫组织在俄亥俄州代顿市注射海洛因/NPF；目标3：定性描述文化和社会的影响 关于在注射疫苗的个人中实施更安全或风险更高行为的战略、实践和策略的背景 俄亥俄州代顿市的海洛因/NPF。拟任首席调查员塔莎·珀杜是一名博士生，领导着一项 南加州大学教师和莱特州立大学中心之间的跨学科研究团队 干预、治疗和成瘾研究。这个高效的跨学科协作团队 能够很好地完成研究目标。这项研究将产生重要的积极影响， 处于发展成有害海洛因/NPF的最高风险的个人的路径使用轨迹 鉴于NPF及其类似物的可获得性的变化，不同的社会背景。在这样做的过程中，项目将 为制定和实施与文化相适应的有针对性的预防和 将减少海洛因/NPF吸毒者危险行为的治疗干预措施 现有的研究。