Key Molecular Mechanisms of Chronic Pain Vulnerability in Women Experiencing MVC

经历 MVC 的女性慢性疼痛脆弱性的关键分子机制

• 批准号: 9896771
• 负责人: Sarah Linnstaedt
• 金额: $ 12.56万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9896771
• 关键词: Accident and Emergency department; Address; Affect; Award; Binding; Biological; Biological Factors; Cells; Chronic; Cognitive; Complement; Complex; Data; Developed Countries; Development; Disease; Distress; Enrollment; Equation; Estradiol; Estrogen Receptors; Estrogen receptor positive; Evaluation; Exposure to; Fright; Funding; Gene Expression Regulation; Genes; Home environment; Incidence; Individual; Influentials; Injury; K-Series Research Career Programs; Knowledge; Lead; Life; Link; Longitudinal cohort; Longitudinal cohort study; Mediating; Mediator of activation protein; Mentors; Methylation; MicroRNAs; Modeling; Molecular; Musculoskeletal Pain; Pain; Pathogenesis; Pathogenicity; Play; Positioning Attribute; Process; Psychosocial Factor; RNA; Regulation; Research; Role; Sampling; Scientist; Severities; Sex Differences; Structure; Training; Translational Research; Trauma; United States National Institutes of Health; Untranslated RNA; Variant; Vehicle crash; Woman; Work; X Chromosome; X Inactivation; biopsychosocial; career development; chronic musculoskeletal pain; chronic pain; clinical effect; experience; female sex hormone; insight; men; pain outcome; promoter; psychosocial; sex; skills; traumatic event

Abstract Exposure to traumatic events is common in life. In industrialized nations, motor vehicle collisions (MVCs) are one of the most common types of trauma, with over 50 million MVCs occurring worldwide each year. The great majority of individuals experiencing MVC do not have serious injury; in the US more than 90% of individuals seen in the emergency department after MVC are discharged home after evaluation. However, a substantial proportion of such individuals develop chronic musculoskeletal pain (MSP). Most individuals who develop chronic MSP following MVC are women. This fact is consistent with the marked increase in MSP burden experienced by women vs. men in other settings. Biopsychosocial mechanisms responsible for this increased vulnerability remain poorly understood, leading the NIH and eminent pain scientists to call for more research aimed at addressing this knowledge gap. The candidate, Dr. Sarah Linnstaedt, is an RNA biologist who seeks a K01 career development award to gain the training necessary to perform studies that will provide important new insights into the biologic mechanisms, and the interactions between these mechanisms and cognitive/psychosocial factors, that contribute to chronic MSP pathogenesis in women. Specifically, the proposed career development award will provide Dr. Linnstaedt with the knowledge and skills necessary to (1) evaluate candidate biological mechanisms within contemporary, state-of-the-art biopsychsocial models of chronic MSP that include influential cognitive and psychosocial factors, (2) perform studies of sex-specific biological mechanisms that previous data, and the candidate’s pilot data, suggest contribute to chronic MSP in women, and (3) evaluate potential interactions between biological and psychosocial factors. Data for this work will be drawn from biologic samples collected as part of a mentor’s longitudinal cohort study of chronic MSP pathogensis after MVC. By the end of the award period, Dr. Linnstaedt will have the necessary knowledge, experience, skills, and data to obtain an R01 and become an independently-funded translational research scientist whose work addresses the current marked disparity in chronic pain incidence among women.

抽象的 接触创伤事件在生活中很常见。在工业化国家，机动车辆碰撞 (MVC) 最常见的创伤类型之一，全世界每年发生超过 5000 万起 MVC。伟大的 大多数经历 MVC 的人并没有受到严重伤害；在美国，超过 90% 的人见过 MVC 后在急诊室进行评估后出院回家。然而，相当大的比例 的此类人患有慢性肌肉骨骼疼痛 (MSP)。 大多数在 MVC 后出现慢性 MSP 的人都是女性。这个事实与标注的一致 在其他环境中，女性与男性相比，MSP 负担有所增加。生物心理社会机制 导致这种脆弱性增加的原因仍然知之甚少，导致美国国立卫生研究院和杰出的疼痛科学家 呼吁进行更多旨在解决这一知识差距的研究。 候选人 Sarah Linnstaedt 博士是一名 RNA 生物学家，正在寻求 K01 职业发展奖 获得进行研究所需的培训，这些研究将为生物学提供重要的新见解 机制，以及这些机制与认知/心理社会因素之间的相互作用， 有助于女性慢性 MSP 发病机制。具体来说，拟议的职业发展奖将 为 Linnstaedt 博士提供 (1) 评估候选生物机制所需的知识和技能 在慢性 MSP 的当代最先进的生物心理社会模型中，包括有影响力的认知和 心理社会因素，（2）对以前的数据和性别特异性生物学机制进行研究 候选人的试点数据，表明有助于女性慢性 MSP，以及 (3) 评估潜在的相互作用 生物因素和社会心理因素之间的关系。这项工作的数据将从收集的生物样本中提取 MVC 后导师对慢性 MSP 发病机制的纵向队列研究的一部分。颁奖结束时 在此期间，Linnstaedt 博士将拥有获得 R01 和 成为一名独立资助的转化研究科学家，其工作解决当前标记的问题 女性慢性疼痛发生率存在差异。