Key Molecular Mechanisms of Chronic Pain Vulnerability in Women Experiencing MVC

摘要 在生活中，接触创伤性事件是很常见的。在工业化国家，机动车碰撞(MVC)是 这是最常见的创伤类型之一，全世界每年发生5000万多起MVC。伟大的 大多数经历MVC的人没有严重伤害；在美国，超过90%的人看到 在急诊科MVC出院后均经过评估。然而，相当大比例的人 这些人中的大多数会发展成慢性肌肉骨骼疼痛(MSP)。 大多数在MVC后发展为慢性MSP的人是女性。这一事实与被标记的 在其他情况下，女性与男性相比，MSP负担增加。生物心理社会机制 对这种增加的脆弱性负有责任的人仍然知之甚少，导致NIH和著名的疼痛科学家 呼吁开展更多旨在解决这一知识鸿沟的研究。 候选人Sarah Linnstaedt博士是一名RNA生物学家，她正在寻求K01职业发展奖，以 获得必要的培训以进行研究，这些研究将为生物学提供重要的新见解 机制，以及这些机制与认知/心理社会因素之间的相互作用， 在女性慢性MSP发病机制中起重要作用。具体地说，拟议的职业发展奖将 为Linnstaedt博士提供必要的知识和技能，以(1)评估候选的生物机制 在当代最先进的慢性MSP生物心理社会模型中，包括有影响力的认知和 心理社会因素，(2)对性别特有的生物机制进行研究，而不是先前的数据，以及 候选人的试点数据，建议有助于女性慢性MSP，以及(3)评估潜在的相互作用 在生物和心理社会因素之间。这项工作的数据将从收集的生物样本中提取 导师对MVC后慢性MSP病因的纵向队列研究的一部分。在颁奖结束前 在此期间，Linnstaedt博士将拥有必要的知识、经验、技能和数据来获得R01和 成为一名独立资助的翻译研究科学家，其工作针对当前被标记的 女性慢性疼痛发病率的差异。

Abstract Exposure to traumatic events is common in life. In industrialized nations, motor vehicle collisions (MVCs) are one of the most common types of trauma, with over 50 million MVCs occurring worldwide each year. The great majority of individuals experiencing MVC do not have serious injury; in the US more than 90% of individuals seen in the emergency department after MVC are discharged home after evaluation. However, a substantial proportion of such individuals develop chronic musculoskeletal pain (MSP). Most individuals who develop chronic MSP following MVC are women. This fact is consistent with the marked increase in MSP burden experienced by women vs. men in other settings. Biopsychosocial mechanisms responsible for this increased vulnerability remain poorly understood, leading the NIH and eminent pain scientists to call for more research aimed at addressing this knowledge gap. The candidate, Dr. Sarah Linnstaedt, is an RNA biologist who seeks a K01 career development award to gain the training necessary to perform studies that will provide important new insights into the biologic mechanisms, and the interactions between these mechanisms and cognitive/psychosocial factors, that contribute to chronic MSP pathogenesis in women. Specifically, the proposed career development award will provide Dr. Linnstaedt with the knowledge and skills necessary to (1) evaluate candidate biological mechanisms within contemporary, state-of-the-art biopsychsocial models of chronic MSP that include influential cognitive and psychosocial factors, (2) perform studies of sex-specific biological mechanisms that previous data, and the candidate’s pilot data, suggest contribute to chronic MSP in women, and (3) evaluate potential interactions between biological and psychosocial factors. Data for this work will be drawn from biologic samples collected as part of a mentor’s longitudinal cohort study of chronic MSP pathogensis after MVC. By the end of the award period, Dr. Linnstaedt will have the necessary knowledge, experience, skills, and data to obtain an R01 and become an independently-funded translational research scientist whose work addresses the current marked disparity in chronic pain incidence among women.