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Polycyclic aromatic hydrocarbons exposure and dietary risk of Esophageal squamous cell carcinoma in Uganda

乌干达多环芳烃暴露和食管鳞状细胞癌的饮食风险

基本信息

批准号：
9897608
负责人：
Samson Okello
金额：
$ 9.16万
依托单位：
MBARARA UNIVERSITY/SCIENCE/ TECHNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-25 至 2022-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9897608
关键词：
Accounting Affect Africa Africa South of the Sahara Age Age of Onset Alcohol consumption Alcohols Area Aromatic Polycyclic Hydrocarbons Attention Award Behavioral Biological Cancer Etiology Carcinogens Case-Control Studies Cessation of life Charcoal Country DNA Methylation Data Diagnosis Diet Dietary Practices Disease Progression Eastern Africa Educational process of instructing Environmental Monitoring Epidemiology Epigenetic Process Epithelial Epithelium Esophageal Squamous Cell Carcinoma Esophageal Tissue Esophagus Exposure to First Independent Research Support and Transition Awards Food Processing Gastroenterology Gastrointestinal Endoscopy Gender Genomics Geography Goals Histologic Hospital Referrals Human Papillomavirus Individual Internal Medicine Intervention Lead Learning Life Malignant neoplasm of esophagus Measurement Measures Mediator of activation protein Medicine Mentors Methods Milk Modeling Modification Molecular Profiling Morbidity - disease rate Nutritional Participant Pathway interactions Patients Phenotype Population Population Attributable Risks Prevalence Prevention Preventive Intervention Public Health Quality of life Research Infrastructure Risk Risk Factors Science Series Services Smoking Somatic Mutation Source Southern Africa Surveys Survival Rate Teaching Hospitals Techniques Technology Testing Therapeutic Intervention Tobacco use Training Uganda Universities Work apprenticeship arm biomass fuel cancer epidemiology cancer genomics carcinogenicity career development cohort design epigenomics food consumption food preparation genetic epidemiology genetic signature genome-wide health goals high risk population improved innovation lecturer low and middle-income countries male modifiable risk mortality novel nutrition outcome forecast prevent prospective rural area sex upper gastrointestinal cancer

项目摘要

Project Summary Esophageal squamous cell carcinoma (ESCC) is the second leading cause of cancer-related death among males in East Africa. In southwestern Uganda, the prevalence of ESCC is increasing while the mean age of diagnosis is decreasing. In addition, ESCC continues to be complicated by late presentation and poor survival rates despite therapy. These changing prevalence and age of onset cannot be explained by known ESCC risk factors including human papillomavirus, alcohol and tobacco use as the prevalence of these risk factors remains low and unchanged. Additional, potentially modifiable risk factors that are contributing to the increase in ESCC have yet to be elucidated. Polycyclic aromatic hydrocarbons exposures in biomass fuel and/or dietary sources are potential explanations of the heightened risk of ESCC in sub-Saharan Africa. The current K43 application seeks to build on previous cross-sectional work that demonstrates male sex, smoking and alcohol as risk factors for ESCC. First, the award will provide the opportunity to strengthen my understanding of measurement and analysis of nutritional data, cancer and genetic epidemiology, and to complete successful apprenticeships with leading experts in cancer genomics, gastroenterology, and nutrition. The proposed training will include brief courses offered through Harvard University and Mbarara University of Science and Technology. Second, my cohort of ESCC patients will enable prospective examination of relationships of polycyclic aromatic hydrocarbon exposures with ESCC. I will also explore genetic and molecular signatures of ESCC in this population. The proposed career development activities and series of studies will deepen our understanding of the biological mechanisms through which biomass fuel and diet affects ESCC risk, with a primary focus on DNA methylation as a mediator. These findings can provide new understanding of pathways to ESCC that may lead to innovative ways to encourage multifactorial risk factor modification in individuals living in ESCC high burden areas in sub-Saharan Africa, a public health goal that has been difficult to attain.

项目总结