Hyperacusis and Central Gain

听觉过敏和中央增益

基本信息

批准号：
9897505
负责人：
RICHARD J SALVI
金额：
$ 45.37万
依托单位：
STATE UNIVERSITY OF NEW YORK AT BUFFALO
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-04-01 至 2022-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9897505
关键词：
Acoustic Stimulation Acoustics Affect Amygdaloid structure Auditory Threshold Basic Science Behavioral Behavioral Assay Clinical Sciences Cochlea Cochlear Hearing Loss Dose Ear Electrophysiology (science)Emotional Environment Frequencies GABA Agonists Goals Growth Hair Cells Hyperactive behavior Hyperacusis Individual Inferior Colliculus Lateral Light Loudness Measures Methods Modeling Neurotransmitters Noise Output Pain Pharmaceutical Preparations Pharmacology Prevalence Property Rattus Reporting Selective Serotonin Reuptake Inhibitor Series Serotonin Agonists Structure System Temporary Threshold Shift Testing Time anxious auditory deprivation auditory pathway behavior measurement behavior test clinically relevant deprivation efficacy testing experience experimental study gamma-Aminobutyric Acid hearing impairment hidden hearing loss insight neuromechanism ototoxicity public health relevance relating to nervous system sound

项目摘要

DESCRIPTION (provided by applicant): Hearing loss from intense noise exposure and ototoxic drugs greatly reduces the neural output of the cochlea. Despite a reduced cochlear output, neural activity in the central auditory pathway often becomes hyperactive at suprathreshold intensities indicative of Enhanced Central Gain. Enhanced Central Gain is believed to be responsible for hyperacusis, a condition in which listeners experience everyday sounds as unbearably loud or even painful. The goals of this project are: (1) Determine if Enhanced Central Gain is responsible for the temporal and spectral features of hyperacusis, (2) Determine how the acoustic environment (sound enrichment/deprivation) modulates hyperacusis/loudness growth and Central Gain and (3) Determine how serotonin and GABA agonists/antagonists affect hyperacusis and Central Gain. The proposed studies will increase our understanding of the neural mechanisms of hyperacusis and test the efficacy of pharmacological agents to treat hyperacusis.

描述（由申请人提供）：强烈的噪声暴露和耳毒性药物的听力损失大大降低了耳蜗的神经输出。尽管人工耳蜗的产量减少，但中央听觉途径的神经活动通常会在上空的强度上过度活跃，这表明中央增益增强。据信，增强的中央收益是造成Hypersisis的原因，在这种情况下，听众每天的声音听起来像响亮甚至痛苦。该项目的目标是：（1）确定增强的中央收益是否负责超气的时间和频谱特征，（2）确定声学环境（声音丰富/剥夺）如何调节HyperAcusis/Hypersis/Houdness Growth and Central增长以及（3）确定血清素和GABA蛋白和GABA蛋白和GABA激动剂/动力学家如何影响HyperAcusis和Central中心的增长。拟议的研究将增加我们对超源神经机制的理解，并测试药理学药物治疗高辅酶的功效。